TY - JOUR T1 - Report of large kinship with familial translocation between chromosomes 21 and 22 JF - Canadian Medical Association Journal JO - CMAJ SP - 1411 LP - 1413 VL - 117 IS - 12 AU - J. E. Brissenden AU - M. T. Costa AU - M. H. Roberts Y1 - 1977/12/17 UR - http://www.cmaj.ca/content/117/12/1411.abstract N2 - This paper reports a large kinship with a familial (21;22) translocation occurring in both the balanced and the unbalanced states. Recurrence risks for the (21;22) translocation in the unbalanced state are high (14%) for the offspring of female carriers as compared with those for the offspring of male carriers (4%), but the offspring of male carriers appear to have a much higher risk (50%) of being balanced carriers than those of female carriers (30%). ER -