RT Journal Article
SR Electronic
T1 IgA nephropathy in adults: immunohistologic findings and clinical course
JF Canadian Medical Association Journal
JO CMAJ
FD Canadian Medical Association
SP 1381
OP 1384
VO 132
IS 12
A1 S. K. Parai
A1 T. Ghose
YR 1985
UL http://www.cmaj.ca/content/132/12/1381.abstract
AB Laboratory examination of specimens from 123 consecutive renal biopsies performed at Victoria General Hospital, Halifax revealed six cases of mesangial deposition, predominantly of IgA, unassociated with systemic disorders. Immunohistologic examination showed deposits of only IgA in one specimen, IgA and IgG in two and IgA, IgG and IgM in three. Glomerular deposits of C3 were seen in five of the specimens, and properdin was seen in three. Glomeruli in all the specimens showed increased matrix and increased numbers of cells in the mesangium. Electron microscopy revealed deposits in the mesangium or capillary wall in all five of the specimens so studied. All six patients had proteinuria, four had microscopic hematuria, and three had hypertension; in one patient the disease progressed to renal failure.