RT Journal Article
SR Electronic
T1 A clinical approach to common electrolyte problems: 4. Hypomagnesemia
JF Canadian Medical Association Journal
JO CMAJ
FD Canadian Medical Association
SP 360
OP 368
VO 132
IS 4
A1 C. Berkelhammer
A1 R. A. Bear
YR 1985
UL http://www.cmaj.ca/content/132/4/360.abstract
AB Magnesium plays a critical role in many cell functions. Hypomagnesemia may occur because of decreased intake or absorption, internal redistribution or increased loss of this element through either renal or nonrenal routes. Manifestations of magnesium deficiency include alterations in calcium, phosphate and potassium homeostasis along with cardiac disorders such as malignant ventricular arrhythmias refractory to conventional therapy, enhanced sensitivity to digoxin and, possibly, coronary artery vasospasm and sudden death. Other features of magnesium deficiency include a host of neuromuscular and neuropsychiatric disorders. In this review we detail mechanisms that may lead to magnesium deficiency, summarize the clinical features of the deficiency and provide a clinical approach to the diagnosis and treatment of this electrolyte disorder.