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Research

Development and validation of the Cambridge Multimorbidity Score

Rupert A. Payne, Silvia C. Mendonca, Marc N. Elliott, Catherine L. Saunders, Duncan A. Edwards, Martin Marshall and Martin Roland
CMAJ February 03, 2020 192 (5) E107-E114; DOI: https://doi.org/10.1503/cmaj.190757
Rupert A. Payne
Centre for Academic Primary Care (Payne), Population Health Sciences, University of Bristol, Bristol, UK; Primary Care Unit (Mendonca, Saunders, Edwards, Roland), Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK; RAND Corporation (Elliott), Santa Monica, Calif.; Research Department of Primary Care and Population Health (Marshall), University College London Medical School, Royal Free Campus, London, UK
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Silvia C. Mendonca
Centre for Academic Primary Care (Payne), Population Health Sciences, University of Bristol, Bristol, UK; Primary Care Unit (Mendonca, Saunders, Edwards, Roland), Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK; RAND Corporation (Elliott), Santa Monica, Calif.; Research Department of Primary Care and Population Health (Marshall), University College London Medical School, Royal Free Campus, London, UK
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Marc N. Elliott
Centre for Academic Primary Care (Payne), Population Health Sciences, University of Bristol, Bristol, UK; Primary Care Unit (Mendonca, Saunders, Edwards, Roland), Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK; RAND Corporation (Elliott), Santa Monica, Calif.; Research Department of Primary Care and Population Health (Marshall), University College London Medical School, Royal Free Campus, London, UK
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Catherine L. Saunders
Centre for Academic Primary Care (Payne), Population Health Sciences, University of Bristol, Bristol, UK; Primary Care Unit (Mendonca, Saunders, Edwards, Roland), Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK; RAND Corporation (Elliott), Santa Monica, Calif.; Research Department of Primary Care and Population Health (Marshall), University College London Medical School, Royal Free Campus, London, UK
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Duncan A. Edwards
Centre for Academic Primary Care (Payne), Population Health Sciences, University of Bristol, Bristol, UK; Primary Care Unit (Mendonca, Saunders, Edwards, Roland), Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK; RAND Corporation (Elliott), Santa Monica, Calif.; Research Department of Primary Care and Population Health (Marshall), University College London Medical School, Royal Free Campus, London, UK
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Martin Marshall
Centre for Academic Primary Care (Payne), Population Health Sciences, University of Bristol, Bristol, UK; Primary Care Unit (Mendonca, Saunders, Edwards, Roland), Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK; RAND Corporation (Elliott), Santa Monica, Calif.; Research Department of Primary Care and Population Health (Marshall), University College London Medical School, Royal Free Campus, London, UK
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Martin Roland
Centre for Academic Primary Care (Payne), Population Health Sciences, University of Bristol, Bristol, UK; Primary Care Unit (Mendonca, Saunders, Edwards, Roland), Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK; RAND Corporation (Elliott), Santa Monica, Calif.; Research Department of Primary Care and Population Health (Marshall), University College London Medical School, Royal Free Campus, London, UK
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Online appendices

  • Appendix 1: Flowchart for the selection of GP practices
  • Appendix 10: Comparison of C-indices (95% confidence intervals) from different model specifications for a Cox model for mortality
  • Appendix 11: Model output for the Cox model for mortality
  • Appendix 12: P-values from the statistical tests on the equivalence between the C-indices from the primary (20-condition) outcome-specific scores and Charlson (columns 4 vs 5 and 8 vs 9 of Appendices 6, 8 and 10)
  • Appendix 13: Calibration plots for the primary outcome-specific scores
  • Appendix 2: Data sets used, relevant time periods and dates
  • Appendix 3: Statistical analysis and data processing
  • Appendix 4: Descriptive statistics for the multimorbidity scores
  • Appendix 5: Prevalence and weights for the extended version of the multimorbidity scores
  • Appendix 6: Comparison of C-indices (95% confidence intervals) from different model specifications for a NB-ZINB model for number of consultations
  • Appendix 7: Model output for number of consultations
  • Appendix 8: Comparison of C-indices (95% confidence intervals) from different model specifications for a Cox model for emergency hospital admission
  • Appendix 9: Model output for the Cox model for emergency hospital admission

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