Online Appendices
- Appendix 1: Search strategy PubMed, EMBASE, Cochrane Library
- Appendix 2: Missing values (%) of the pre-specified signs & symptoms and CRP in the 8 individual patient datasets
- Appendix 3: Basic and extended models
- Appendix 4: Table of characteristics of excluded studies
- Appendix 5: Overview of methodological quality. Methodological quality of included validation datasets according to QUADAS-2 assessment
- Appendix 6: Reclassification table illustrating the improved diagnostic risk classification after adding CRP to the diagnostic work-up of patients suspected of CAP in a hypothetical cohort of 1000 patients, based on a relatively low CAP prevalence of 5%
- Appendix 7: Reclassification table illustrating the improved diagnostic risk classification after adding CRP to the diagnostic work-up of patients suspected of CAP in a hypothetical cohort of 1000 patients, based on a relatively high CAP prevalence of 20