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Original Articles

Glucose-responsive insulin and glucagon delivery (dual-hormone artificial pancreas) in adults with type 1 diabetes: a randomized crossover controlled trial

Ahmad Haidar, Laurent Legault, Maryse Dallaire, Ammar Alkhateeb, Adèle Coriati, Virginie Messier, Peiyao Cheng, Maude Millette, Benoit Boulet, Chiu-Ching Huang and Rémi Rabasa-Lhoret
CMAJ January 28, 2013 cmaj.121265; DOI: https://doi.org/10.1503/cmaj.121265
Ahmad Haidar
Institut de Recherches Cliniques de Montréal (Haidar, Dallaire, Alkhateeb, Coriati, Messier, Rabasa-Lhoret); the Centre for Intelligent Machines, McGill University (Haidar, Boulet); the Montréal Children's Hospital (Legault, Millette); the Nutrition Department (Rabasa-Lhoret), Université de Montréal; and the Endocrinology Division (Rabasa- Lhoret), Montreal University Hospital, Montréal, Que.; and the Jaeb Center for Health Research (Cheng), Tampa, Fla.
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Laurent Legault
Institut de Recherches Cliniques de Montréal (Haidar, Dallaire, Alkhateeb, Coriati, Messier, Rabasa-Lhoret); the Centre for Intelligent Machines, McGill University (Haidar, Boulet); the Montréal Children's Hospital (Legault, Millette); the Nutrition Department (Rabasa-Lhoret), Université de Montréal; and the Endocrinology Division (Rabasa- Lhoret), Montreal University Hospital, Montréal, Que.; and the Jaeb Center for Health Research (Cheng), Tampa, Fla.
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Maryse Dallaire
Institut de Recherches Cliniques de Montréal (Haidar, Dallaire, Alkhateeb, Coriati, Messier, Rabasa-Lhoret); the Centre for Intelligent Machines, McGill University (Haidar, Boulet); the Montréal Children's Hospital (Legault, Millette); the Nutrition Department (Rabasa-Lhoret), Université de Montréal; and the Endocrinology Division (Rabasa- Lhoret), Montreal University Hospital, Montréal, Que.; and the Jaeb Center for Health Research (Cheng), Tampa, Fla.
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Ammar Alkhateeb
Institut de Recherches Cliniques de Montréal (Haidar, Dallaire, Alkhateeb, Coriati, Messier, Rabasa-Lhoret); the Centre for Intelligent Machines, McGill University (Haidar, Boulet); the Montréal Children's Hospital (Legault, Millette); the Nutrition Department (Rabasa-Lhoret), Université de Montréal; and the Endocrinology Division (Rabasa- Lhoret), Montreal University Hospital, Montréal, Que.; and the Jaeb Center for Health Research (Cheng), Tampa, Fla.
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Adèle Coriati
Institut de Recherches Cliniques de Montréal (Haidar, Dallaire, Alkhateeb, Coriati, Messier, Rabasa-Lhoret); the Centre for Intelligent Machines, McGill University (Haidar, Boulet); the Montréal Children's Hospital (Legault, Millette); the Nutrition Department (Rabasa-Lhoret), Université de Montréal; and the Endocrinology Division (Rabasa- Lhoret), Montreal University Hospital, Montréal, Que.; and the Jaeb Center for Health Research (Cheng), Tampa, Fla.
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Virginie Messier
Institut de Recherches Cliniques de Montréal (Haidar, Dallaire, Alkhateeb, Coriati, Messier, Rabasa-Lhoret); the Centre for Intelligent Machines, McGill University (Haidar, Boulet); the Montréal Children's Hospital (Legault, Millette); the Nutrition Department (Rabasa-Lhoret), Université de Montréal; and the Endocrinology Division (Rabasa- Lhoret), Montreal University Hospital, Montréal, Que.; and the Jaeb Center for Health Research (Cheng), Tampa, Fla.
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Peiyao Cheng
Institut de Recherches Cliniques de Montréal (Haidar, Dallaire, Alkhateeb, Coriati, Messier, Rabasa-Lhoret); the Centre for Intelligent Machines, McGill University (Haidar, Boulet); the Montréal Children's Hospital (Legault, Millette); the Nutrition Department (Rabasa-Lhoret), Université de Montréal; and the Endocrinology Division (Rabasa- Lhoret), Montreal University Hospital, Montréal, Que.; and the Jaeb Center for Health Research (Cheng), Tampa, Fla.
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Maude Millette
Institut de Recherches Cliniques de Montréal (Haidar, Dallaire, Alkhateeb, Coriati, Messier, Rabasa-Lhoret); the Centre for Intelligent Machines, McGill University (Haidar, Boulet); the Montréal Children's Hospital (Legault, Millette); the Nutrition Department (Rabasa-Lhoret), Université de Montréal; and the Endocrinology Division (Rabasa- Lhoret), Montreal University Hospital, Montréal, Que.; and the Jaeb Center for Health Research (Cheng), Tampa, Fla.
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Benoit Boulet
Institut de Recherches Cliniques de Montréal (Haidar, Dallaire, Alkhateeb, Coriati, Messier, Rabasa-Lhoret); the Centre for Intelligent Machines, McGill University (Haidar, Boulet); the Montréal Children's Hospital (Legault, Millette); the Nutrition Department (Rabasa-Lhoret), Université de Montréal; and the Endocrinology Division (Rabasa- Lhoret), Montreal University Hospital, Montréal, Que.; and the Jaeb Center for Health Research (Cheng), Tampa, Fla.
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Chiu-Ching Huang
Institut de Recherches Cliniques de Montréal (Haidar, Dallaire, Alkhateeb, Coriati, Messier, Rabasa-Lhoret); the Centre for Intelligent Machines, McGill University (Haidar, Boulet); the Montréal Children's Hospital (Legault, Millette); the Nutrition Department (Rabasa-Lhoret), Université de Montréal; and the Endocrinology Division (Rabasa- Lhoret), Montreal University Hospital, Montréal, Que.; and the Jaeb Center for Health Research (Cheng), Tampa, Fla.
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Rémi Rabasa-Lhoret
Institut de Recherches Cliniques de Montréal (Haidar, Dallaire, Alkhateeb, Coriati, Messier, Rabasa-Lhoret); the Centre for Intelligent Machines, McGill University (Haidar, Boulet); the Montréal Children's Hospital (Legault, Millette); the Nutrition Department (Rabasa-Lhoret), Université de Montréal; and the Endocrinology Division (Rabasa- Lhoret), Montreal University Hospital, Montréal, Que.; and the Jaeb Center for Health Research (Cheng), Tampa, Fla.
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Online Appendices

  • Appendix 1: Study Exclusion Criteria
  • Appendix 2: Algorithm and Meal Description
  • Appendix 3: Supplementary Figures and Tables

  View article

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