Research
Efficacy and safety of antiviral treatment for COVID-19 from evidence in studies of SARS-CoV-2 and other acute viral infections: a systematic review and meta-analysis
Wei Liu, Pengxiang Zhou, Ken Chen, Zhikang Ye, Fang Liu, Xiaotong Li, Na He, Ziyang Wu, Qi Zhang, Xuepeng Gong, Qiyu Tang, Xin Du, Yingqiu Ying, Xiaohan Xu, Yahui Zhang, Jinyu Liu, Yun Li, Ning Shen, Rachel J. Couban, Quazi I. Ibrahim, Gordon Guyatt and Suodi Zhai
CMAJ July 06, 2020 192 (27) E734-E744; DOI: https://doi.org/10.1503/cmaj.200647
Wei Liu
Department of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
PhDPengxiang Zhou
Department of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
MPharmKen Chen
Department of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
MPharmZhikang Ye
Department of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
MPharmFang Liu
Department of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
MScXiaotong Li
Department of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
MScNa He
Department of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
MScZiyang Wu
Department of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
BScQi Zhang
Department of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
MScXuepeng Gong
Department of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
PhDQiyu Tang
Department of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
BScXin Du
Department of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
BScYingqiu Ying
Department of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
MScXiaohan Xu
Department of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
MScYahui Zhang
Department of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
BScJinyu Liu
Department of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
PhDYun Li
Department of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
MScNing Shen
Department of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
MDRachel J. Couban
Department of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
MAQuazi I. Ibrahim
Department of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
MScGordon Guyatt
Department of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
MD MScSuodi Zhai
Department of Pharmacy (W. Liu, Zhou, F. Liu, Li, He, Wu, Q. Zhang, Tang, Du, Ying, Xu, Y. Zhang, Li, Zhai), Peking University Third Hospital, Beijing, China; Institute for Drug Evaluation (Zhai, F. Liu), Departments of Pharmacy Administration and Clinical Pharmacy (Wu, Du, Y. Zhang), and Respiratory and Critical Care Medicine (Shen), Peking University Health Science Center, Beijing, China; College of Pharmacy (Chen), University of Nebraska Medical Center, Omaha, Neb.; Department of Health Research Methods, Evidence and Impact (Ye, Ibrahim, Guyatt), McMaster University, Hamilton, Ont.; Department of Pharmacy (Gong, J. Liu), Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; DeGroote Institute for Pain Research and Care (Couban), McMaster University, Hamilton, Ont.; Pharmacy Department (Y. Li), First Hospital of Shanxi Medical University, Taiyuan, Shanxi, China
BScData supplements
Online appendices
- Appendix 1: Protocol for systematic review on use of antiviral agents in COVID-19 patients
- Appendix 2: Search Strategy
- Appendix 3: PRISMA Flow Diagrams
- Appendix 4: Forest plots of included studies
- Appendix 5: GRADE summary of findings on antivirals in COVID-19
- Appendix 6: Additional statistical analysis on ref. Zhou Q
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Efficacy and safety of antiviral treatment for COVID-19 from evidence in studies of SARS-CoV-2 and other acute viral infections: a systematic review and meta-analysis
Wei Liu, Pengxiang Zhou, Ken Chen, Zhikang Ye, Fang Liu, Xiaotong Li, Na He, Ziyang Wu, Qi Zhang, Xuepeng Gong, Qiyu Tang, Xin Du, Yingqiu Ying, Xiaohan Xu, Yahui Zhang, Jinyu Liu, Yun Li, Ning Shen, Rachel J. Couban, Quazi I. Ibrahim, Gordon Guyatt, Suodi Zhai
CMAJ Jul 2020, 192 (27) E734-E744; DOI: 10.1503/cmaj.200647
Efficacy and safety of antiviral treatment for COVID-19 from evidence in studies of SARS-CoV-2 and other acute viral infections: a systematic review and meta-analysis
Wei Liu, Pengxiang Zhou, Ken Chen, Zhikang Ye, Fang Liu, Xiaotong Li, Na He, Ziyang Wu, Qi Zhang, Xuepeng Gong, Qiyu Tang, Xin Du, Yingqiu Ying, Xiaohan Xu, Yahui Zhang, Jinyu Liu, Yun Li, Ning Shen, Rachel J. Couban, Quazi I. Ibrahim, Gordon Guyatt, Suodi Zhai
CMAJ Jul 2020, 192 (27) E734-E744; DOI: 10.1503/cmaj.200647
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