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Research
Open Access

Predicting death in home care users: derivation and validation of the Risk Evaluation for Support: Predictions for Elder-Life in the Community Tool (RESPECT)

Amy T. Hsu, Douglas G. Manuel, Sarah Spruin, Carol Bennett, Monica Taljaard, Sarah Beach, Yulric Sequeira, Robert Talarico, Mathieu Chalifoux, Daniel Kobewka, Andrew P. Costa, Susan E. Bronskill and Peter Tanuseputro
CMAJ July 05, 2021 193 (26) E997-E1005; DOI: https://doi.org/10.1503/cmaj.200022
Amy T. Hsu
Bruyère Research Institute (Hsu, Manuel, Tanuseputro); Clinical Epidemiology Program (Hsu, Manuel, Bennett, Taljaard, Beach, Sequeira, Kobewka, Tanuseputro), Ottawa Hospital Research Institute; ICES uOttawa (Chalifoux, Manuel, Spruin, Talarico, Tanuseputro); School of Epidemiology and Public Health (Taljaard, Manuel), Division of Palliative Care (Tanuseputro) and Department of Medicine (Kobewka), University of Ottawa, Ottawa, Ont.; Department of Clinical Epidemiology and Biostatistics (Costa), McMaster University, Hamilton, Ont.; ICES Central (Bronskill); Women’s College Research Institute (Bronskill), Women’s College Hospital, Toronto, Ont.
PhD
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Douglas G. Manuel
Bruyère Research Institute (Hsu, Manuel, Tanuseputro); Clinical Epidemiology Program (Hsu, Manuel, Bennett, Taljaard, Beach, Sequeira, Kobewka, Tanuseputro), Ottawa Hospital Research Institute; ICES uOttawa (Chalifoux, Manuel, Spruin, Talarico, Tanuseputro); School of Epidemiology and Public Health (Taljaard, Manuel), Division of Palliative Care (Tanuseputro) and Department of Medicine (Kobewka), University of Ottawa, Ottawa, Ont.; Department of Clinical Epidemiology and Biostatistics (Costa), McMaster University, Hamilton, Ont.; ICES Central (Bronskill); Women’s College Research Institute (Bronskill), Women’s College Hospital, Toronto, Ont.
MD MSc
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Sarah Spruin
Bruyère Research Institute (Hsu, Manuel, Tanuseputro); Clinical Epidemiology Program (Hsu, Manuel, Bennett, Taljaard, Beach, Sequeira, Kobewka, Tanuseputro), Ottawa Hospital Research Institute; ICES uOttawa (Chalifoux, Manuel, Spruin, Talarico, Tanuseputro); School of Epidemiology and Public Health (Taljaard, Manuel), Division of Palliative Care (Tanuseputro) and Department of Medicine (Kobewka), University of Ottawa, Ottawa, Ont.; Department of Clinical Epidemiology and Biostatistics (Costa), McMaster University, Hamilton, Ont.; ICES Central (Bronskill); Women’s College Research Institute (Bronskill), Women’s College Hospital, Toronto, Ont.
MSc
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Carol Bennett
Bruyère Research Institute (Hsu, Manuel, Tanuseputro); Clinical Epidemiology Program (Hsu, Manuel, Bennett, Taljaard, Beach, Sequeira, Kobewka, Tanuseputro), Ottawa Hospital Research Institute; ICES uOttawa (Chalifoux, Manuel, Spruin, Talarico, Tanuseputro); School of Epidemiology and Public Health (Taljaard, Manuel), Division of Palliative Care (Tanuseputro) and Department of Medicine (Kobewka), University of Ottawa, Ottawa, Ont.; Department of Clinical Epidemiology and Biostatistics (Costa), McMaster University, Hamilton, Ont.; ICES Central (Bronskill); Women’s College Research Institute (Bronskill), Women’s College Hospital, Toronto, Ont.
MSc
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Monica Taljaard
Bruyère Research Institute (Hsu, Manuel, Tanuseputro); Clinical Epidemiology Program (Hsu, Manuel, Bennett, Taljaard, Beach, Sequeira, Kobewka, Tanuseputro), Ottawa Hospital Research Institute; ICES uOttawa (Chalifoux, Manuel, Spruin, Talarico, Tanuseputro); School of Epidemiology and Public Health (Taljaard, Manuel), Division of Palliative Care (Tanuseputro) and Department of Medicine (Kobewka), University of Ottawa, Ottawa, Ont.; Department of Clinical Epidemiology and Biostatistics (Costa), McMaster University, Hamilton, Ont.; ICES Central (Bronskill); Women’s College Research Institute (Bronskill), Women’s College Hospital, Toronto, Ont.
PhD
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Sarah Beach
Bruyère Research Institute (Hsu, Manuel, Tanuseputro); Clinical Epidemiology Program (Hsu, Manuel, Bennett, Taljaard, Beach, Sequeira, Kobewka, Tanuseputro), Ottawa Hospital Research Institute; ICES uOttawa (Chalifoux, Manuel, Spruin, Talarico, Tanuseputro); School of Epidemiology and Public Health (Taljaard, Manuel), Division of Palliative Care (Tanuseputro) and Department of Medicine (Kobewka), University of Ottawa, Ottawa, Ont.; Department of Clinical Epidemiology and Biostatistics (Costa), McMaster University, Hamilton, Ont.; ICES Central (Bronskill); Women’s College Research Institute (Bronskill), Women’s College Hospital, Toronto, Ont.
MSc
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Yulric Sequeira
Bruyère Research Institute (Hsu, Manuel, Tanuseputro); Clinical Epidemiology Program (Hsu, Manuel, Bennett, Taljaard, Beach, Sequeira, Kobewka, Tanuseputro), Ottawa Hospital Research Institute; ICES uOttawa (Chalifoux, Manuel, Spruin, Talarico, Tanuseputro); School of Epidemiology and Public Health (Taljaard, Manuel), Division of Palliative Care (Tanuseputro) and Department of Medicine (Kobewka), University of Ottawa, Ottawa, Ont.; Department of Clinical Epidemiology and Biostatistics (Costa), McMaster University, Hamilton, Ont.; ICES Central (Bronskill); Women’s College Research Institute (Bronskill), Women’s College Hospital, Toronto, Ont.
BEng
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Robert Talarico
Bruyère Research Institute (Hsu, Manuel, Tanuseputro); Clinical Epidemiology Program (Hsu, Manuel, Bennett, Taljaard, Beach, Sequeira, Kobewka, Tanuseputro), Ottawa Hospital Research Institute; ICES uOttawa (Chalifoux, Manuel, Spruin, Talarico, Tanuseputro); School of Epidemiology and Public Health (Taljaard, Manuel), Division of Palliative Care (Tanuseputro) and Department of Medicine (Kobewka), University of Ottawa, Ottawa, Ont.; Department of Clinical Epidemiology and Biostatistics (Costa), McMaster University, Hamilton, Ont.; ICES Central (Bronskill); Women’s College Research Institute (Bronskill), Women’s College Hospital, Toronto, Ont.
MSc
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Mathieu Chalifoux
Bruyère Research Institute (Hsu, Manuel, Tanuseputro); Clinical Epidemiology Program (Hsu, Manuel, Bennett, Taljaard, Beach, Sequeira, Kobewka, Tanuseputro), Ottawa Hospital Research Institute; ICES uOttawa (Chalifoux, Manuel, Spruin, Talarico, Tanuseputro); School of Epidemiology and Public Health (Taljaard, Manuel), Division of Palliative Care (Tanuseputro) and Department of Medicine (Kobewka), University of Ottawa, Ottawa, Ont.; Department of Clinical Epidemiology and Biostatistics (Costa), McMaster University, Hamilton, Ont.; ICES Central (Bronskill); Women’s College Research Institute (Bronskill), Women’s College Hospital, Toronto, Ont.
MSc
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Daniel Kobewka
Bruyère Research Institute (Hsu, Manuel, Tanuseputro); Clinical Epidemiology Program (Hsu, Manuel, Bennett, Taljaard, Beach, Sequeira, Kobewka, Tanuseputro), Ottawa Hospital Research Institute; ICES uOttawa (Chalifoux, Manuel, Spruin, Talarico, Tanuseputro); School of Epidemiology and Public Health (Taljaard, Manuel), Division of Palliative Care (Tanuseputro) and Department of Medicine (Kobewka), University of Ottawa, Ottawa, Ont.; Department of Clinical Epidemiology and Biostatistics (Costa), McMaster University, Hamilton, Ont.; ICES Central (Bronskill); Women’s College Research Institute (Bronskill), Women’s College Hospital, Toronto, Ont.
MD MSc
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Andrew P. Costa
Bruyère Research Institute (Hsu, Manuel, Tanuseputro); Clinical Epidemiology Program (Hsu, Manuel, Bennett, Taljaard, Beach, Sequeira, Kobewka, Tanuseputro), Ottawa Hospital Research Institute; ICES uOttawa (Chalifoux, Manuel, Spruin, Talarico, Tanuseputro); School of Epidemiology and Public Health (Taljaard, Manuel), Division of Palliative Care (Tanuseputro) and Department of Medicine (Kobewka), University of Ottawa, Ottawa, Ont.; Department of Clinical Epidemiology and Biostatistics (Costa), McMaster University, Hamilton, Ont.; ICES Central (Bronskill); Women’s College Research Institute (Bronskill), Women’s College Hospital, Toronto, Ont.
PhD
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Susan E. Bronskill
Bruyère Research Institute (Hsu, Manuel, Tanuseputro); Clinical Epidemiology Program (Hsu, Manuel, Bennett, Taljaard, Beach, Sequeira, Kobewka, Tanuseputro), Ottawa Hospital Research Institute; ICES uOttawa (Chalifoux, Manuel, Spruin, Talarico, Tanuseputro); School of Epidemiology and Public Health (Taljaard, Manuel), Division of Palliative Care (Tanuseputro) and Department of Medicine (Kobewka), University of Ottawa, Ottawa, Ont.; Department of Clinical Epidemiology and Biostatistics (Costa), McMaster University, Hamilton, Ont.; ICES Central (Bronskill); Women’s College Research Institute (Bronskill), Women’s College Hospital, Toronto, Ont.
PhD
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Peter Tanuseputro
Bruyère Research Institute (Hsu, Manuel, Tanuseputro); Clinical Epidemiology Program (Hsu, Manuel, Bennett, Taljaard, Beach, Sequeira, Kobewka, Tanuseputro), Ottawa Hospital Research Institute; ICES uOttawa (Chalifoux, Manuel, Spruin, Talarico, Tanuseputro); School of Epidemiology and Public Health (Taljaard, Manuel), Division of Palliative Care (Tanuseputro) and Department of Medicine (Kobewka), University of Ottawa, Ottawa, Ont.; Department of Clinical Epidemiology and Biostatistics (Costa), McMaster University, Hamilton, Ont.; ICES Central (Bronskill); Women’s College Research Institute (Bronskill), Women’s College Hospital, Toronto, Ont.
MHSc MD
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Data supplements

  • Online appendices

    • Appendix 1: Estimated hazard ratios (HR) of predictors excluded from the final model
    • Appendix 10: Calibration graph
    • Appendix 2: Cox proportional hazards regression estimates for predictors of 6-month mortality in the derivation and combined cohorts
    • Appendix 3: Derivation of RESPECT risk score and bin
    • Appendix 4: Predicted 6-month mortality risk, sample size and median survival across 61 risk groups of RESPECT
    • Appendix 5: RESPECT web calculator user guide
    • Appendix 6: Detailed description of the study cohorts
    • Appendix 7: Characteristics of individuals across the 61 risk groups of RESPECT
    • Appendix 8: Calibration plot for 6-month mortality risk in the validation cohort across the 61 risk groups generated from RESPECT
    • Appendix 9: Calibration graphs of key predictors of 6-month mortality in the validation cohort
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  • Heckman, G. A., Hubbard, R. E., & Millar, N. (2021). Mortality risk of patients in home care is modifiable. CMAJ, 193(34), E1358. Accessed September 24, 2023. https://doi.org/10.1503/cmaj.79701.
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Canadian Medical Association Journal: 193 (26)
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Predicting death in home care users: derivation and validation of the Risk Evaluation for Support: Predictions for Elder-Life in the Community Tool (RESPECT)
Amy T. Hsu, Douglas G. Manuel, Sarah Spruin, Carol Bennett, Monica Taljaard, Sarah Beach, Yulric Sequeira, Robert Talarico, Mathieu Chalifoux, Daniel Kobewka, Andrew P. Costa, Susan E. Bronskill, Peter Tanuseputro
CMAJ Jul 2021, 193 (26) E997-E1005; DOI: 10.1503/cmaj.200022

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Predicting death in home care users: derivation and validation of the Risk Evaluation for Support: Predictions for Elder-Life in the Community Tool (RESPECT)
Amy T. Hsu, Douglas G. Manuel, Sarah Spruin, Carol Bennett, Monica Taljaard, Sarah Beach, Yulric Sequeira, Robert Talarico, Mathieu Chalifoux, Daniel Kobewka, Andrew P. Costa, Susan E. Bronskill, Peter Tanuseputro
CMAJ Jul 2021, 193 (26) E997-E1005; DOI: 10.1503/cmaj.200022
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