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Practice

Craniotabes in a newborn

Yuko Wada, Katsuyuki Kubo and Shinichi Tsubata
CMAJ October 05, 2020 192 (40) E1163; DOI: https://doi.org/10.1503/cmaj.200192
Yuko Wada
Department of Pediatrics, Toyama Red Cross Hospital, Toyama, Japan
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Katsuyuki Kubo
Department of Pediatrics, Toyama Red Cross Hospital, Toyama, Japan
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Shinichi Tsubata
Department of Pediatrics, Toyama Red Cross Hospital, Toyama, Japan
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A 40-year-old woman who was G2P2 delivered a full-term male infant after an uncomplicated prenatal course. On physical examination of the newborn, we could not palpate the cranial bones at the top of his head. His extremities and facial appearance showed no abnormalities that would suggest syndromic malformation. Cranial computed tomography showed extensive areas of delayed ossification along the sagittal suture, and multiple small lesions in the temporal and occipital bones, which we did not detect on physical examination (Figure 1A and B).

Figure 1:
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Figure 1:

Three-dimensional reconstructed cranial computed tomography images of a newborn boy showing multiple sites of extensive craniotabes on (A) the top and (B) the right side of his head.

Laboratory tests performed on the neonate’s fifth day of life showed the following results: serum 25-hydroxyvitamin D level of 14.1 (normal range 20–100) ng/mL) and increased parathyroid hormone level of 91 (normal range 10–60) pg/mL). We diagnosed vitamin D deficiency and secondary hyperparathyroidism. Radiographs of his extremities did not show evidence of rickets. His mother had no history of syphilis nor had she restricted her diet or sun exposure. However, her serum 25-hydroxyvitamin D level was low (9.4 [normal range, 30–100] ng/mL). We prescribed normal feeding with vitamin D supplementation, which resulted in improved serum vitamin D levels. The infant’s cranial bones hardened at 2 months of age, and he has shown normal development thereafter.

The incidence of craniotabes, defined as a softening of the skull bones, ranges from 20% to 30% internationally (although severe cases like we describe here are rare) and is directly correlated with maternal vitamin D levels.1 With adequate nutrition, it resolves spontaneously within 2–3 months.1 Craniotabes is also associated with pathological conditions, such as rickets, congenital syphilis or skeletal dysplasias.1 Our case was most likely due to maternal vitamin D deficiency. The prevalence of vitamin D deficiency in pregnant woman ranges from 50% to 70% in developed countries, depending on geographic location.2

The American College of Obstetricians and Gynecologists recommends that pregnant women receive 600 IU/day of supplemental vitamin D; however, 1000–2000 IU/day may be needed if vitamin D deficiency is identified.3

Acknowledgement

The authors thank Dr. Neil Bowles for his assistance with the editing of the manuscript.

Footnotes

  • Competing interests: None declared.

  • This article has been peer reviewed.

  • The authors have obtained parental consent.

References

  1. ↵
    1. Yorifuji J,
    2. Yorifuji T,
    3. Tachibana K,
    4. et al
    . Craniotabes in normal newborns: the earliest sign of subclinical vitamin D deficiency. J Clin Endocrinol Metab 2008;93:1784–8.
    OpenUrlCrossRefPubMed
  2. ↵
    1. Saraf R,
    2. Morton SM,
    3. Camargo CA Jr.,
    4. et al
    . Global summary of maternal and newborn vitamin D status — a systematic review. Matern Child Nutr 2016;12:647–68.
    OpenUrl
  3. ↵
    ACOG Committee on Obstetric Practice. ACOG Committee Opinion No. 495: Vitamin D: screening and supplementation during pregnancy. Obstet Gynecol 2011;118:197–8 [reaffirmed 2017].
    OpenUrlCrossRefPubMed
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Canadian Medical Association Journal: 192 (40)
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Vol. 192, Issue 40
5 Oct 2020
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Craniotabes in a newborn
Yuko Wada, Katsuyuki Kubo, Shinichi Tsubata
CMAJ Oct 2020, 192 (40) E1163; DOI: 10.1503/cmaj.200192

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Craniotabes in a newborn
Yuko Wada, Katsuyuki Kubo, Shinichi Tsubata
CMAJ Oct 2020, 192 (40) E1163; DOI: 10.1503/cmaj.200192
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