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Analysis

Development of a framework for critical care resource allocation for the COVID-19 pandemic in Saskatchewan

Sabira Valiani, Luke Terrett, Colin Gebhardt, Oksana Prokopchuk-Gauk and Melody Isinger
CMAJ September 14, 2020 192 (37) E1067-E1073; DOI: https://doi.org/10.1503/cmaj.200756
Sabira Valiani
Department of Adult Critical Care Medicine (Valiani, Terrett, Gebhardt); Divisions of Transfusion Medicine (Prokopchuk-Gauk) and Ethics (Isinger), Saskatchewan Health Authority; College of Medicine (Valiani, Terrett, Gebhardt, Prokopchuk-Gauk), University of Saskatchewan, Saskatoon, Sask.
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Luke Terrett
Department of Adult Critical Care Medicine (Valiani, Terrett, Gebhardt); Divisions of Transfusion Medicine (Prokopchuk-Gauk) and Ethics (Isinger), Saskatchewan Health Authority; College of Medicine (Valiani, Terrett, Gebhardt, Prokopchuk-Gauk), University of Saskatchewan, Saskatoon, Sask.
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Colin Gebhardt
Department of Adult Critical Care Medicine (Valiani, Terrett, Gebhardt); Divisions of Transfusion Medicine (Prokopchuk-Gauk) and Ethics (Isinger), Saskatchewan Health Authority; College of Medicine (Valiani, Terrett, Gebhardt, Prokopchuk-Gauk), University of Saskatchewan, Saskatoon, Sask.
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Oksana Prokopchuk-Gauk
Department of Adult Critical Care Medicine (Valiani, Terrett, Gebhardt); Divisions of Transfusion Medicine (Prokopchuk-Gauk) and Ethics (Isinger), Saskatchewan Health Authority; College of Medicine (Valiani, Terrett, Gebhardt, Prokopchuk-Gauk), University of Saskatchewan, Saskatoon, Sask.
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Melody Isinger
Department of Adult Critical Care Medicine (Valiani, Terrett, Gebhardt); Divisions of Transfusion Medicine (Prokopchuk-Gauk) and Ethics (Isinger), Saskatchewan Health Authority; College of Medicine (Valiani, Terrett, Gebhardt, Prokopchuk-Gauk), University of Saskatchewan, Saskatoon, Sask.
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  • Figure 1:
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    Figure 1:

    Critical care triage stage 4 protocol for patients with coronavirus disease 2019 in Saskatchewan. Note: ACP = advance care planning, Fio2 = fraction of inspired oxygen, GOC = goals of care, SOFA = Sequential Organ Failure Assessment, Spo2 = oxygen saturation. Extracorporeal life support (ECLS) may provide effective treatment for refractory cases, but it requires extensive resources. Each request for ECLS will be reviewed by at least 2 ECLS experts, in addition to the triage team. These ECLS experts will be designated by the area leads of the Department of Critical Care (Regina and Saskatoon). The number of patients that can be placed on ECLS is small and should be decided on a case-by-case basis. Definite exclusion criteria include age older than 60 years; receiving mechanical ventilation for more than 7 days; irreversible neurologic, multiorgan failure; malignancy; cardiac arrest; severe end-stage liver, lung, kidney or heart disease; advanced neurocognitive disease; pregnancy; body mass index > 45; inability to receive anticoagulation or blood products; or ECLS resources not available in city. Legend: red = highest priority patient (most likely to benefit from admission to the intensive care unit [ICU]), yellow = intermediate priority patient (may benefit from ICU care), green = patient does not require ICU care (too well), blue = palliative care only (poor prognosis is likely).

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    Table 1:

    Detailed exclusion criteria

    CriteriaCritical care triage stage 1Critical care triage stage 2Critical care triage stages 3 and 4
    Patient preferenceAs documented by goals-of-care and advance care planning discussions
    • As documented by goals-of-care and advance care planning discussions

    As documented by goals-of-care and advance care planning discussions
    Past medical historyClinician judgment; must be mutually agreed upon by patient and clinician
    • End-stage organ failure*

      • Heart failure NYHA class IV

      • Lung disease

        • COPD with FEV1 < 30% predicted or baseline Pao2 < 55 mm Hg, or secondary pulmonary hypertension

        • Cystic fibrosis with postbronchodilator FEV1 < 30% predicted or baseline Pao2 < 55 mm Hg

        • Pulmonary fibrosis with VC or TLC < 60% predicted, baseline Pao2 < 55 mm Hg or secondary pulmonary hypertension

        • Primary pulmonary hypertension with NYHA class IV symptoms

      • Cirrhosis with MELD > 20

    • Metastatic malignant disease with expected survival of < 6 mo

    • Advanced and irreversible immunocompromise

    • Severe, irreversible and terminal neurologic event or condition (end-stage dementia)

    • Advanced untreatable neurodegenerative disease (Parkinson disease, ALS)

    • End-stage organ failure*

      • Heart failure NYHA class III or IV

      • Lung disease

        • COPD with FEV1 < 30% predicted or baseline Pao2 < 55 mm Hg, or secondary pulmonary hypertension

        • Cystic fibrosis with postbronchodilator FEV1 < 30% predicted or baseline Pao2 < 55 mm Hg

        • Pulmonary fibrosis with VC or TLC < 60% predicted, baseline Pao2 < 55 mm Hg or secondary pulmonary hypertension

        • Primary pulmonary hypertension with NYHA class IV symptoms

      • Cirrhosis with MELD > 20

    Severity of presenting illnessClinician judgment; must be mutually agreed upon by patient and clinician
    • Age > 80 yr and cardiac arrest with 1 of the following poor prognostic factors:†

      • Unwitnessed cardiac arrest

      • Any PEA arrest

      • Recurrent cardiac arrest

    • Cardiac arrest, regardless of age, with 1 of the following poor prognostic factors:

      • Unwitnessed cardiac arrest

      • Any PEA arrest

      • Recurrent cardiac arrest

    • Severe trauma or burns

      • Trauma with ISS > 16, unless determined to be acutely reversible

      • Burns with 2 of the following:

        • Age > 60 yr, > 40% BSA, inhalational injury

      • Severe neurologic injury

        • TBI meeting all of the following criteria:

        • Age > 60 yr, GCS < 8, and 1 or both unreactive pupils

      • SAH with WFNS grade V

      • CVA

        • Age > 70 yr with large MCA territory CVA, substantial deficits, not amenable to reperfusion

      • Posterior circulation stroke with GCS < 8

    Age and Clinical Frailty ScoreClinician judgment; must be mutually agreed upon by patient and clinicianClinician judgment; must be mutually agreed upon by patient and clinician
    • Age > 80 yr and

    • Clinical Frailty Score ≥ 5

    • Note: ALS = amyotrophic lateral sclerosis, BSA = body surface area, COPD = chronic obstructive pulmonary disease, CVA = cerebrovascular accident, FEV1 = forced expiratory volume in 1 minute, GCS = Glasgow Coma Scale, ICU = intensive care unit, ISS = Injury Severity Score, MCA = middle cerebral artery, MELD = Model for End-Stage Liver Disease, NYHA = New York Heart Association, PEA = pulseless electrical activity, SAH = subarachnoid hemorrhage, TBI = traumatic brain injury, TLC = total lung capacity, VC = vital capacity, WFNS = World Federation of Neurosurgical Societies.

    • ↵* If the patient is currently on a waiting list for organ transplant and admission to the ICU would place them at the top of the waiting list, an exception should be made and the patient should be admitted to the ICU. However, if organ donation programs are put on hold because of the pandemic, this exception is no longer valid.

    • ↵† If the patient’s most responsible physician determines the cause of the cardiac arrest to be acutely reversible, the patient is not excluded from ICU care.

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    Table 2:

    Special populations

    PopulationRationaleIncorporation into the Saskatchewan Critical Care Resource Allocation Framework
    Older adultsEvidence suggests that risk for poor ICU outcomes is not defined exclusively by age.13 Instead, frailty (defined as CFS ≥ 5) is associated with higher in-hospital and long-term mortality.14 In octogenarians, frailty is predictive of short-term ICU mortality.15,16 Although frailty may portend a poorer outcome in younger patients who are critically ill, the validity of applying the CFS more broadly is still being investigated.17A combination of age and frailty is used as exclusion criteria in stage 3 (Table 1).
    Chronically ventilatedPalliation for patients on long-term ventilation is not justifiable, even if it allows a greater number of healthier patients to survive. This policy would risk inappropriate quality-of-life judgments and could be seen as disadvantaging vulnerable patients.Patients who are already receiving life-sustaining treatments in long-term care settings or at home are considered to be a different population altogether from the medical patient who is acutely ill. However, should patients receiving long-term ventilation require treatment in an acute care facility, they should be considered part of the acute care cohort and subject to the resource allocation framework.2
    Patients with disabilitiesPatients with intellectual, physical or developmental disabilities are considered vulnerable populations and at risk for discrimination within the health care system.18 Patients with stable, nonprogressive conditions will not be excluded solely on the basis of these conditions.The structure and process of the triage team is meant to form a system of checks and balances to eliminate discrimination based on disability.
    Pregnant patientsA patient who is pregnant and her potentially viable fetus should be considered as 2 separate lives, and therefore these patients can be prioritized based on the life-cycle principle.19Pregnancy with a potentially viable fetus is included as a tiebreaker in stage 4 (Figure 1).
    Health care workersHealth care workers have instrumental value (i.e., a health care worker who is healthy can save the lives of more patients).10,20 However, during a stage of critical illness, it is unclear whether the health care worker, if saved, would be able to return to work in a timely fashion to help others. Instrumental value is a potentially subjective concept that lends itself too easily to other, potentially extraneous, considerations of social worth.Health care workers are included as tiebreakers in stage 4 (Figure 1).
    • Note: CFS = Clinical Frailty Score, ICU = intensive care unit.

    • View popup
    Table 3:

    Comparison of critical care triage stages

    Triage stageBaseline ICU capacity, %ScarcityInclusion criteriaExclusion criteria overview (see Table 1)Withdrawal of life-supportive treatment
    1100–150RelativeAccording to usual clinical practiceAccording to usual clinical practiceAccording to usual clinical practice
    2150–200RelativeAccording to usual clinical practice
    • End-stage organ failure

    • Cardiac arrest with poor prognostic factors

    According to usual clinical practice
    3200–250RelativeAccording to usual clinical practice
    • End-stage organ failure

    • Terminal neurologic diseases

    • Metastatic malignant disease with poor prognosis

    • Cardiac arrest with poor prognostic factors

    • Severe trauma or burns

    • Severe neurologic injury

    • Age > 80 yr and Clinical Frailty Score ≥ 5

    According to usual clinical practice
    4> 250AbsoluteFormal inclusion criteria (Figure 1)According to stage 3 exclusion criteriaFormalized reassessments and uniform criteria for palliation
    • Note: ICU = intensive care unit.

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Canadian Medical Association Journal: 192 (37)
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Vol. 192, Issue 37
14 Sep 2020
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Development of a framework for critical care resource allocation for the COVID-19 pandemic in Saskatchewan
Sabira Valiani, Luke Terrett, Colin Gebhardt, Oksana Prokopchuk-Gauk, Melody Isinger
CMAJ Sep 2020, 192 (37) E1067-E1073; DOI: 10.1503/cmaj.200756

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Development of a framework for critical care resource allocation for the COVID-19 pandemic in Saskatchewan
Sabira Valiani, Luke Terrett, Colin Gebhardt, Oksana Prokopchuk-Gauk, Melody Isinger
CMAJ Sep 2020, 192 (37) E1067-E1073; DOI: 10.1503/cmaj.200756
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    • What are the key ethical principles for resource allocation in a pandemic?
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