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Research

Prepregnancy renal function and risk of preterm birth and related outcomes

Ziv Harel, Alison L. Park, Eric McArthur, Michelle Hladunewich, Jade S. Dirk, Ron Wald, Amit X. Garg and Joel G. Ray
CMAJ July 27, 2020 192 (30) E851-E857; DOI: https://doi.org/10.1503/cmaj.200089
Ziv Harel
Division of Nephrology (Harel, Wald) and Department of Medicine (Ray), St. Michael’s Hospital, Toronto, Ont.; ICES (Park, McArthur, Dirk, Garg, Ray), Ontario; Division of Nephrology (Hladunewich), Sunnybrook Health Sciences Centre, Toronto, Ont.; Division of Nephrology (Garg), Western University, London, Ont.
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Alison L. Park
Division of Nephrology (Harel, Wald) and Department of Medicine (Ray), St. Michael’s Hospital, Toronto, Ont.; ICES (Park, McArthur, Dirk, Garg, Ray), Ontario; Division of Nephrology (Hladunewich), Sunnybrook Health Sciences Centre, Toronto, Ont.; Division of Nephrology (Garg), Western University, London, Ont.
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Eric McArthur
Division of Nephrology (Harel, Wald) and Department of Medicine (Ray), St. Michael’s Hospital, Toronto, Ont.; ICES (Park, McArthur, Dirk, Garg, Ray), Ontario; Division of Nephrology (Hladunewich), Sunnybrook Health Sciences Centre, Toronto, Ont.; Division of Nephrology (Garg), Western University, London, Ont.
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Michelle Hladunewich
Division of Nephrology (Harel, Wald) and Department of Medicine (Ray), St. Michael’s Hospital, Toronto, Ont.; ICES (Park, McArthur, Dirk, Garg, Ray), Ontario; Division of Nephrology (Hladunewich), Sunnybrook Health Sciences Centre, Toronto, Ont.; Division of Nephrology (Garg), Western University, London, Ont.
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Jade S. Dirk
Division of Nephrology (Harel, Wald) and Department of Medicine (Ray), St. Michael’s Hospital, Toronto, Ont.; ICES (Park, McArthur, Dirk, Garg, Ray), Ontario; Division of Nephrology (Hladunewich), Sunnybrook Health Sciences Centre, Toronto, Ont.; Division of Nephrology (Garg), Western University, London, Ont.
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Ron Wald
Division of Nephrology (Harel, Wald) and Department of Medicine (Ray), St. Michael’s Hospital, Toronto, Ont.; ICES (Park, McArthur, Dirk, Garg, Ray), Ontario; Division of Nephrology (Hladunewich), Sunnybrook Health Sciences Centre, Toronto, Ont.; Division of Nephrology (Garg), Western University, London, Ont.
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Amit X. Garg
Division of Nephrology (Harel, Wald) and Department of Medicine (Ray), St. Michael’s Hospital, Toronto, Ont.; ICES (Park, McArthur, Dirk, Garg, Ray), Ontario; Division of Nephrology (Hladunewich), Sunnybrook Health Sciences Centre, Toronto, Ont.; Division of Nephrology (Garg), Western University, London, Ont.
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Joel G. Ray
Division of Nephrology (Harel, Wald) and Department of Medicine (Ray), St. Michael’s Hospital, Toronto, Ont.; ICES (Park, McArthur, Dirk, Garg, Ray), Ontario; Division of Nephrology (Hladunewich), Sunnybrook Health Sciences Centre, Toronto, Ont.; Division of Nephrology (Garg), Western University, London, Ont.
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    Figure 1:

    Study flow diagram for creation of the main cohort of pregnancies with measurement of serum creatinine (SCr) within 10 weeks before conception, as well as the subcohort of pregnancies with apparently healthy renal function at the time of conception. *In the subcohort with chronic kidney disease, the frequencies of individual conditions are nonexclusive.

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    Table 1:

    Characteristics of pregnancies with measurement of serum creatinine within 10 weeks before conception

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    Table 2:

    Risk of primary outcome (preterm birth < 37 weeks’ gestation) and secondary outcomes in association with abnormal prepregnancy serum creatinine (SCr)*

    Table 2:
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Canadian Medical Association Journal: 192 (30)
CMAJ
Vol. 192, Issue 30
27 Jul 2020
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Prepregnancy renal function and risk of preterm birth and related outcomes
Ziv Harel, Alison L. Park, Eric McArthur, Michelle Hladunewich, Jade S. Dirk, Ron Wald, Amit X. Garg, Joel G. Ray
CMAJ Jul 2020, 192 (30) E851-E857; DOI: 10.1503/cmaj.200089

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Prepregnancy renal function and risk of preterm birth and related outcomes
Ziv Harel, Alison L. Park, Eric McArthur, Michelle Hladunewich, Jade S. Dirk, Ron Wald, Amit X. Garg, Joel G. Ray
CMAJ Jul 2020, 192 (30) E851-E857; DOI: 10.1503/cmaj.200089
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