Skip to main content

Main menu

  • Home
  • COVID-19
    • Articles & podcasts
    • Blog posts
    • Collection
    • News
  • Content
    • Current issue
    • Past issues
    • Early releases
    • Collections
    • Sections
    • Blog
    • Infographics & illustrations
    • Podcasts
    • Classified ads
  • Authors
    • Overview for authors
    • Submission guidelines
    • Submit a manuscript
    • Forms
    • Editorial process
    • Editorial policies
    • Peer review process
    • Publication fees
    • Reprint requests
  • CMA Members
    • Overview for members
    • Earn CPD Credits
    • Print copies of CMAJ
    • Career Ad Discount
  • Subscribers
    • General information
    • View prices
  • Alerts
    • Email alerts
    • RSS
  • JAMC
    • À propos
    • Numéro en cours
    • Archives
    • Sections
    • Abonnement
    • Alertes
  • CMAJ JOURNALS
    • CMAJ Open
    • CJS
    • JAMC
    • JPN

User menu

Search

  • Advanced search
CMAJ
  • CMAJ JOURNALS
    • CMAJ Open
    • CJS
    • JAMC
    • JPN
CMAJ

Advanced Search

  • Home
  • COVID-19
    • Articles & podcasts
    • Blog posts
    • Collection
    • News
  • Content
    • Current issue
    • Past issues
    • Early releases
    • Collections
    • Sections
    • Blog
    • Infographics & illustrations
    • Podcasts
    • Classified ads
  • Authors
    • Overview for authors
    • Submission guidelines
    • Submit a manuscript
    • Forms
    • Editorial process
    • Editorial policies
    • Peer review process
    • Publication fees
    • Reprint requests
  • CMA Members
    • Overview for members
    • Earn CPD Credits
    • Print copies of CMAJ
    • Career Ad Discount
  • Subscribers
    • General information
    • View prices
  • Alerts
    • Email alerts
    • RSS
  • JAMC
    • À propos
    • Numéro en cours
    • Archives
    • Sections
    • Abonnement
    • Alertes
  • Visit CMAJ on Facebook
  • Follow CMAJ on Twitter
  • Follow CMAJ on Pinterest
  • Follow CMAJ on Youtube
  • Follow CMAJ on Instagram
Letters

Improved cell-purification techniques and safety monitoring needed for olfactory ensheathing cell transplantation

Richard D. Bartlett, James B. Phillips and David Choi
CMAJ October 28, 2019 191 (43) E1199; DOI: https://doi.org/10.1503/cmaj.73255
Richard D. Bartlett
MB/PhD researcher, University College London Centre for Nerve Engineering, London, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
James B. Phillips
Reader in regenerative medicine, University College London Centre for Nerve Engineering, London, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David Choi
Professor of neurosurgery, University College London Centre for Nerve Engineering and National Hospital for Neurology and Neurosurgery, London, UK
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Responses
  • Metrics
  • PDF
Loading

Woodworth and colleagues highlight an important complication 12 years after a patient received a transplantation of olfactory mucosa tissue into the spinal cord.1 This report, combined with others cited by the authors, emphasizes that long-term follow-up after cell transplantation must be performed and reported as a matter of routine. This is essential for ensuring adequate patient safety; yet, it is at odds with the short follow-up times specified by many current trials on cell therapy.

We find it unsurprising that aberrant growth was observed after the transplantation of whole olfactory mucosa tissue. The olfactory mucosa is rich in a number of cell types,2 including the pseudostratified columnar epithelial cells noted on histology from the patient in this case.1 In the original study by Lima and colleagues, the use of whole tissue was justified because cell suspensions lead to poor cell viability and do not adequately fill the lesion space.3 These concerns are justifiable,4 but we challenge the idea that transplanting whole tissue is the only way to overcome such issues. Indeed, we would like to draw attention to new approaches being developed by our group and others,5 in which tissue engineering and biomaterial-based approaches have the potential to enhance the delivery of olfactory ensheathing cells.

Olfactory ensheathing cells still have great potential for treating spinal cord injuries,6 but this case report in CMAJ1 reinforces the need for improved cell-purification techniques and safety monitoring. A better understanding of the constituents of the source material and the potential beneficial or adverse effects of individual cell subgroups within the mucosa would be desirable before further clinical studies take place.

Footnotes

  • Competing interests: Richard Bartlett reports grants from The Sackler Fund (MB/PhD award). James Phillips is the co-founder of the University College London (UCL) spin-out company Glialign Ltd., which focuses on peripheral nerve repair (not spinal cord injury, which is the subject of this letter). He has received no income from the company and is not a director. James Phillips is an inventor on the following patents: 2013 Phillips and Georgiou, Engineered neural tissue (WO 2015015185); and 2004 Phillips and Brown, Self-aligning tissue growth guide (WO 2004087231). These are broadly in the area of organizing therapeutic cells within hydrogels but are not linked to any of the studies reported in the manuscript. David Choi reports support from University College London Hospitals National Institute for Health Research Biomedical Research Centre and grants from Wellcome Trust.

References

  1. ↵
    1. Woodworth CF,
    2. Jenkins G,
    3. Barron J,
    4. et al
    . Intramedullary cervical spinal mass after stem cell transplantation using an olfactory mucosal cell autograft. CMAJ 2019;191:E761–4.
    OpenUrlFREE Full Text
  2. ↵
    1. Chen CR,
    2. Kachramanoglou C,
    3. Li D,
    4. et al
    . Anatomy and cellular constituents of the human olfactory mucosa: a review. J Neurol Surg B Skull Base 2014; 75: 293–300.
    OpenUrlCrossRef
  3. ↵
    1. Lima C,
    2. Pratas-Vital J,
    3. Escada P,
    4. et al
    . Olfactory mucosa autografts in human spinal cord injury: a pilot clinical study. J Spinal Cord Med 2006;29: 191–203, discussion 204–6.
    OpenUrlPubMed
  4. ↵
    1. Li Y,
    2. Yu Hl,
    3. Chen LF,
    4. et al
    . Survival and number of olfactory ensheathing cells transplanted in contused spinal cord of rats. Chin J Traumatol 2010;13: 356–61.
    OpenUrlPubMed
  5. ↵
    1. Bartlett R,
    2. Roberton V,
    3. Choi D,
    4. et al
    . Tissue engineering to enhance cell therapy for traumatic spinal cord injury. In Proceedings of the Twelfth International Conference on Tissue Engineering & Regenerative Medicine; 2019 Nov. 11–12 2019; Madrid (Spain);p. 740.
  6. ↵
    1. Watzlawick R,
    2. Rind J,
    3. Sena ES,
    4. et al
    . Olfactory ensheathing cell transplantation in experimental spinal cord injury: effect size and reporting bias of 62 experimental treatments: a systematic review and meta-analysis. PLoS Biol 2016;14: e1002468.
    OpenUrlCrossRefPubMed
PreviousNext
Back to top

In this issue

Canadian Medical Association Journal: 191 (43)
CMAJ
Vol. 191, Issue 43
28 Oct 2019
  • Table of Contents
  • Index by author

Article tools

Respond to this article
Print
Download PDF
Article Alerts
To sign up for email alerts or to access your current email alerts, enter your email address below:
Email Article

Thank you for your interest in spreading the word on CMAJ.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Improved cell-purification techniques and safety monitoring needed for olfactory ensheathing cell transplantation
(Your Name) has sent you a message from CMAJ
(Your Name) thought you would like to see the CMAJ web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Improved cell-purification techniques and safety monitoring needed for olfactory ensheathing cell transplantation
Richard D. Bartlett, James B. Phillips, David Choi
CMAJ Oct 2019, 191 (43) E1199; DOI: 10.1503/cmaj.73255

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
‍ Request Permissions
Share
Improved cell-purification techniques and safety monitoring needed for olfactory ensheathing cell transplantation
Richard D. Bartlett, James B. Phillips, David Choi
CMAJ Oct 2019, 191 (43) E1199; DOI: 10.1503/cmaj.73255
Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Footnotes
    • References
  • Responses
  • Metrics
  • PDF

Related Articles

  • Intramedullary cervical spinal mass after stem cell transplantation using an olfactory mucosal cell autograft
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • Coexisting failures do not diminish the stature of a giant
  • Dare we hope
  • Highlighting obesity as a risk factor for endometrial cancer
Show more Letters

Similar Articles

Content

  • Current issue
  • Past issues
  • Collections
  • Sections
  • Blog
  • Podcasts
  • Alerts
  • RSS
  • Early releases

Information for

  • Advertisers
  • Authors
  • Reviewers
  • CMA Members
  • Media
  • Reprint requests
  • Subscribers

About

  • General Information
  • Journal staff
  • Editorial Board
  • Governance Council
  • Journal Oversight
  • Careers
  • Contact
  • Copyright and Permissions

Copyright 2021, Joule Inc. or its licensors. All rights reserved. ISSN 1488-2329 (e) 0820-3946 (p)

All editorial matter in CMAJ represents the opinions of the authors and not necessarily those of the Canadian Medical Association or its subsidiaries.

Powered by HighWire