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Research

The Personal Genome Project Canada: findings from whole genome sequences of the inaugural 56 participants

Miriam S. Reuter, Susan Walker, Bhooma Thiruvahindrapuram, Joe Whitney, Iris Cohn, Neal Sondheimer, Ryan K.C. Yuen, Brett Trost, Tara A. Paton, Sergio L. Pereira, Jo-Anne Herbrick, Richard F. Wintle, Daniele Merico, Jennifer Howe, Jeffrey R. MacDonald, Chao Lu, Thomas Nalpathamkalam, Wilson W.L. Sung, Zhuozhi Wang, Rohan V. Patel, Giovanna Pellecchia, John Wei, Lisa J. Strug, Sherilyn Bell, Barbara Kellam, Melanie M. Mahtani, Anne S. Bassett, Yvonne Bombard, Rosanna Weksberg, Cheryl Shuman, Ronald D. Cohn, Dimitri J. Stavropoulos, Sarah Bowdin, Matthew R. Hildebrandt, Wei Wei, Asli Romm, Peter Pasceri, James Ellis, Peter Ray, M. Stephen Meyn, Nasim Monfared, S. Mohsen Hosseini, Ann M. Joseph-George, Fred W. Keeley, Ryan A. Cook, Marc Fiume, Hin C. Lee, Christian R. Marshall, Jill Davies, Allison Hazell, Janet A. Buchanan, Michael J. Szego and Stephen W. Scherer
CMAJ February 05, 2018 190 (5) E126-E136; DOI: https://doi.org/10.1503/cmaj.171151
Miriam S. Reuter
The Centre for Applied Genomics (Reuter, Walker, Thiruvahindrapuram, Whitney, Yuen, Trost, Paton, Pereira, Herbrick, Wintle, Merico, Howe, MacDonald, Lu, Nalpathamkalam, Sung, Wang, Patel, Pellecchia, J. Wei, Strug, Bell, Kellam, Mahtani, Hosseini, Fiume, Marshall, Buchanan, Scherer); Divisions of Clinical Pharmacology and Toxicology (I. Cohn), or Clinical, and Metabolic Genetics (Sondheimer, Weksberg, Shuman, Bowdin, Meyn, Monfared), The Hospital for Sick Children; Departments of Paediatrics (Sondheimer, R. Cohn) and Molecular Genetics (Yuen, Weksberg, Shuman, R. Cohn, Ellis, Meyn), University of Toronto; Deep Genomics Inc. (Merico); Department of Psychiatry (Bassett), University Health Network and Centre for Addiction and Mental Health, University of Toronto; Li Ka Shing Knowledge Institute (Bombard), St. Michael’s Hospital; Institute of Health Policy, Management and Evaluation (Bombard), University of Toronto; Centre for Genetic Medicine (Stavropoulos, Bowdin, Ray, Monfared); Molecular Genetics Laboratory (Stavropoulos, Ray, Marshall), Division of Genome Diagnostics, Paediatric Laboratory Medicine; Developmental and Stem Cell Biology (Hildebrandt, W. Wei, Romm, Pasceri, Ellis); Ted Rogers Cardiac Genome Clinic (Hosseini); Cytogenetics Laboratory (Joseph-George), Division of Genome Diagnostics, Paediatric Laboratory Medicine, The Hospital for Sick Children; Departments of Biochemistry and Laboratory Medicine, and Pathobiology (Keeley), University of Toronto; DNAstack (Cook, Fiume); McLaughlin Centre (Lee, Scherer), University of Toronto; Medcan Health Management Inc. (Davies, Hazell); Dalla Lana School of Public Health (Szego), Department of Family and Community Medicine, and The Joint Centre for Bioethics, University of Toronto; Centre for Clinical Ethics (Szego), St. Joseph’s Health Centre, Toronto, Ont.
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Susan Walker
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Bhooma Thiruvahindrapuram
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Joe Whitney
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Iris Cohn
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Neal Sondheimer
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Ryan K.C. Yuen
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Brett Trost
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Tara A. Paton
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Sergio L. Pereira
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Chao Lu
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Ronald D. Cohn
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Dimitri J. Stavropoulos
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Christian R. Marshall
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Allison Hazell
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Michael J. Szego
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Stephen W. Scherer
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  • For correspondence: stephen.scherer@sickkids.ca
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Article Information

vol. 190 no. 5 E126-E136
DOI 
https://doi.org/10.1503/cmaj.171151
PubMed 
29431110
History 
  • Accepted December 22, 2017
  • Published online February 2, 2018.
Copyright & Usage 
© 2018 Joule Inc. or its licensors

Author Information

  1. Miriam S. Reuter, MD,
  2. Susan Walker, PhD,
  3. Bhooma Thiruvahindrapuram, MSc,
  4. Joe Whitney, MSc,
  5. Iris Cohn, MSc RPh,
  6. Neal Sondheimer, MD PhD,
  7. Ryan K.C. Yuen, PhD,
  8. Brett Trost, PhD,
  9. Tara A. Paton, PhD,
  10. Sergio L. Pereira, PhD,
  11. Jo-Anne Herbrick, BSc,
  12. Richard F. Wintle, PhD,
  13. Daniele Merico, PhD,
  14. Jennifer Howe,
  15. Jeffrey R. MacDonald, BSc,
  16. Chao Lu, PhD,
  17. Thomas Nalpathamkalam, BSc,
  18. Wilson W.L. Sung, MSc,
  19. Zhuozhi Wang, PhD,
  20. Rohan V. Patel, MSc,
  21. Giovanna Pellecchia, PhD,
  22. John Wei, PhD,
  23. Lisa J. Strug, PhD,
  24. Sherilyn Bell, BSc,
  25. Barbara Kellam, BSc,
  26. Melanie M. Mahtani, PhD,
  27. Anne S. Bassett, MD,
  28. Yvonne Bombard, PhD,
  29. Rosanna Weksberg, MD PhD,
  30. Cheryl Shuman, MS,
  31. Ronald D. Cohn, MD,
  32. Dimitri J. Stavropoulos, PhD,
  33. Sarah Bowdin, MD MSc,
  34. Matthew R. Hildebrandt, PhD,
  35. Wei Wei, MSc,
  36. Asli Romm, MSc,
  37. Peter Pasceri, BSc,
  38. James Ellis, PhD,
  39. Peter Ray, PhD,
  40. M. Stephen Meyn, MD PhD,
  41. Nasim Monfared, MSc,
  42. S. Mohsen Hosseini, MD PhD,
  43. Ann M. Joseph-George, PhD,
  44. Fred W. Keeley, PhD,
  45. Ryan A. Cook, MBA BSc,
  46. Marc Fiume, PhD,
  47. Hin C. Lee, PhD,
  48. Christian R. Marshall, PhD,
  49. Jill Davies, MSc,
  50. Allison Hazell, MSc,
  51. Janet A. Buchanan, PhD,
  52. Michael J. Szego, PhD,
  53. Stephen W. Scherer, PhD⇑
  1. The Centre for Applied Genomics (Reuter, Walker, Thiruvahindrapuram, Whitney, Yuen, Trost, Paton, Pereira, Herbrick, Wintle, Merico, Howe, MacDonald, Lu, Nalpathamkalam, Sung, Wang, Patel, Pellecchia, J. Wei, Strug, Bell, Kellam, Mahtani, Hosseini, Fiume, Marshall, Buchanan, Scherer); Divisions of Clinical Pharmacology and Toxicology (I. Cohn), or Clinical, and Metabolic Genetics (Sondheimer, Weksberg, Shuman, Bowdin, Meyn, Monfared), The Hospital for Sick Children; Departments of Paediatrics (Sondheimer, R. Cohn) and Molecular Genetics (Yuen, Weksberg, Shuman, R. Cohn, Ellis, Meyn), University of Toronto; Deep Genomics Inc. (Merico); Department of Psychiatry (Bassett), University Health Network and Centre for Addiction and Mental Health, University of Toronto; Li Ka Shing Knowledge Institute (Bombard), St. Michael’s Hospital; Institute of Health Policy, Management and Evaluation (Bombard), University of Toronto; Centre for Genetic Medicine (Stavropoulos, Bowdin, Ray, Monfared); Molecular Genetics Laboratory (Stavropoulos, Ray, Marshall), Division of Genome Diagnostics, Paediatric Laboratory Medicine; Developmental and Stem Cell Biology (Hildebrandt, W. Wei, Romm, Pasceri, Ellis); Ted Rogers Cardiac Genome Clinic (Hosseini); Cytogenetics Laboratory (Joseph-George), Division of Genome Diagnostics, Paediatric Laboratory Medicine, The Hospital for Sick Children; Departments of Biochemistry and Laboratory Medicine, and Pathobiology (Keeley), University of Toronto; DNAstack (Cook, Fiume); McLaughlin Centre (Lee, Scherer), University of Toronto; Medcan Health Management Inc. (Davies, Hazell); Dalla Lana School of Public Health (Szego), Department of Family and Community Medicine, and The Joint Centre for Bioethics, University of Toronto; Centre for Clinical Ethics (Szego), St. Joseph’s Health Centre, Toronto, Ont.
  1. Correspondence to: Stephen Scherer, stephen.scherer{at}sickkids.ca
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The Personal Genome Project Canada: findings from whole genome sequences of the inaugural 56 participants
Miriam S. Reuter, Susan Walker, Bhooma Thiruvahindrapuram, Joe Whitney, Iris Cohn, Neal Sondheimer, Ryan K.C. Yuen, Brett Trost, Tara A. Paton, Sergio L. Pereira, Jo-Anne Herbrick, Richard F. Wintle, Daniele Merico, Jennifer Howe, Jeffrey R. MacDonald, Chao Lu, Thomas Nalpathamkalam, Wilson W.L. Sung, Zhuozhi Wang, Rohan V. Patel, Giovanna Pellecchia, John Wei, Lisa J. Strug, Sherilyn Bell, Barbara Kellam, Melanie M. Mahtani, Anne S. Bassett, Yvonne Bombard, Rosanna Weksberg, Cheryl Shuman, Ronald D. Cohn, Dimitri J. Stavropoulos, Sarah Bowdin, Matthew R. Hildebrandt, Wei Wei, Asli Romm, Peter Pasceri, James Ellis, Peter Ray, M. Stephen Meyn, Nasim Monfared, S. Mohsen Hosseini, Ann M. Joseph-George, Fred W. Keeley, Ryan A. Cook, Marc Fiume, Hin C. Lee, Christian R. Marshall, Jill Davies, Allison Hazell, Janet A. Buchanan, Michael J. Szego, Stephen W. Scherer
CMAJ Feb 2018, 190 (5) E126-E136; DOI: 10.1503/cmaj.171151

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The Personal Genome Project Canada: findings from whole genome sequences of the inaugural 56 participants
Miriam S. Reuter, Susan Walker, Bhooma Thiruvahindrapuram, Joe Whitney, Iris Cohn, Neal Sondheimer, Ryan K.C. Yuen, Brett Trost, Tara A. Paton, Sergio L. Pereira, Jo-Anne Herbrick, Richard F. Wintle, Daniele Merico, Jennifer Howe, Jeffrey R. MacDonald, Chao Lu, Thomas Nalpathamkalam, Wilson W.L. Sung, Zhuozhi Wang, Rohan V. Patel, Giovanna Pellecchia, John Wei, Lisa J. Strug, Sherilyn Bell, Barbara Kellam, Melanie M. Mahtani, Anne S. Bassett, Yvonne Bombard, Rosanna Weksberg, Cheryl Shuman, Ronald D. Cohn, Dimitri J. Stavropoulos, Sarah Bowdin, Matthew R. Hildebrandt, Wei Wei, Asli Romm, Peter Pasceri, James Ellis, Peter Ray, M. Stephen Meyn, Nasim Monfared, S. Mohsen Hosseini, Ann M. Joseph-George, Fred W. Keeley, Ryan A. Cook, Marc Fiume, Hin C. Lee, Christian R. Marshall, Jill Davies, Allison Hazell, Janet A. Buchanan, Michael J. Szego, Stephen W. Scherer
CMAJ Feb 2018, 190 (5) E126-E136; DOI: 10.1503/cmaj.171151
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