Routine bloodwork |
Complete blood count Liver enzymes (alanine transaminase, aspartate transaminase, alkaline phosphatase) Liver function (bilirubin, INR, albumin) Creatinine
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Serology to exclude other infections |
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If HIV-positive, treatment for HIV must take drug interactions into consideration If HBsAg-positive or anti-HBc-positive, see section on HBV coinfection (risk of HBV reactivation) (Appendix 1)
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Serology to exclude other common liver diseases |
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Staging of liver disease |
APRI* FibroTest (serum panel)† Ultrasound* Transient elastography†
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All persons with HCV must have evaluation of fibrosis to exclude cirrhosis. Normal ultrasound does not exclude cirrhosis. (21) APRI < 0.7 has a very high negative predictive value to exclude cirrhosis (22)
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HCV-specific |
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