Validation and diagnostic accuracy of predictive curves for age-associated longitudinal cognitive decline in older adults

Patrick J. Bernier; Christian Gourdeau; Pierre-Hugues Carmichael; Jean-Pierre Beauchemin; René Verreault; Rémi W. Bouchard; Edeltraut Kröger; Robert Laforce

doi:10.1503/cmaj.160792

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Validation and diagnostic accuracy of predictive curves for age-associated longitudinal cognitive decline in older adults

Patrick J. Bernier, Christian Gourdeau, Pierre-Hugues Carmichael, Jean-Pierre Beauchemin, René Verreault, Rémi W. Bouchard, Edeltraut Kröger and Robert Laforce

CMAJ December 04, 2017 189 (48) E1472-E1480; DOI: https://doi.org/10.1503/cmaj.160792

Patrick J. Bernier

Services Gériatriques Spécialisés (Bernier), Centre intégré universitaire de santé et de services sociaux (CIUSSS) de la Capitale-Nationale; CÉGEP de Limoilou (Gourdeau); Centre d’excellence sur le vieillissement de Québec (Carmichael, Verreault, Kröger); Institut universitaire de cardiologie et de pneumologie de Québec (Beauchemin); Faculté de médecine (Verreault, Laforce), Université Laval; Clinique interdisciplinaire de mémoire (Bouchard, Laforce), Centre hospitalier universitaire (CHU) de Québec; Faculté de pharmacie (Kröger), Université Laval, Québec, Que.

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Christian Gourdeau

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Pierre-Hugues Carmichael

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Jean-Pierre Beauchemin

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René Verreault

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Rémi W. Bouchard

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Edeltraut Kröger

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Robert Laforce Jr.

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For correspondence: robert.laforce@fmed.ulaval.ca

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Appendix 1: Summary of the CSHA and NACC database characteristics
Appendix 2: Derivation of the model
Appendix 3: Relationship between age and MMSE, and education and MMSE
Appendix 4: Histograms representing the distributions of the MMSE and QuoCo Distribution of MMSE
Appendix 5: ROC curve
Appendix 6: Relationship between Sa and the QuoCo for HC, CIND and Dementia
Appendix 7: Variations in sensitivity and specificity according to population subgroups
Appendix 8: Representative cases

Costa, A. (2017). Charting age-associated cognitive decline. CMAJ, 189(48), E1470-E1471. Accessed April 01, 2020. https://doi.org/10.1503/cmaj.171295.

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Canadian Medical Association Journal: 189 (48)

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4 Dec 2017

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Validation and diagnostic accuracy of predictive curves for age-associated longitudinal cognitive decline in older adults

Patrick J. Bernier, Christian Gourdeau, Pierre-Hugues Carmichael, Jean-Pierre Beauchemin, René Verreault, Rémi W. Bouchard, Edeltraut Kröger, Robert Laforce

CMAJ Dec 2017, 189 (48) E1472-E1480; DOI: 10.1503/cmaj.160792

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Validation and diagnostic accuracy of predictive curves for age-associated longitudinal cognitive decline in older adults

Patrick J. Bernier, Christian Gourdeau, Pierre-Hugues Carmichael, Jean-Pierre Beauchemin, René Verreault, Rémi W. Bouchard, Edeltraut Kröger, Robert Laforce

CMAJ Dec 2017, 189 (48) E1472-E1480; DOI: 10.1503/cmaj.160792

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