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Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies
Meghan B. Azad, Ahmed M. Abou-Setta, Bhupendrasinh F. Chauhan, Rasheda Rabbani, Justin Lys, Leslie Copstein, Amrinder Mann, Maya M. Jeyaraman, Ashleigh E. Reid, Michelle Fiander, Dylan S. MacKay, Jon McGavock, Brandy Wicklow and Ryan Zarychanski
CMAJ July 17, 2017 189 (28) E929-E939; DOI: https://doi.org/10.1503/cmaj.161390
Meghan B. Azad
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
PhDAhmed M. Abou-Setta
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
MD, PhDBhupendrasinh F. Chauhan
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
MPharm, PhDRasheda Rabbani
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
PhDJustin Lys
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
MDLeslie Copstein
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
MDAmrinder Mann
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
MDMaya M. Jeyaraman
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
MD, PhDAshleigh E. Reid
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
MPASMichelle Fiander
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
MLISDylan S. MacKay
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
PhDJon McGavock
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
PhDBrandy Wicklow
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
MD, MScRyan Zarychanski
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
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Related Articles
- Sievenpiper, J. L., Khan, T. A., Ha, V., Viguiliouk, E., & Auyeung, R. (2017). The importance of study design in the assessment of nonnutritive sweeteners and cardiometabolic health. CMAJ, 189(46), E1424-E1425. Accessed April 19, 2024. https://doi.org/10.1503/cmaj.733381.
- Nakajima, K., Iwane, T., & Higuchi, R. (2017). The timing of ingestion may influence the effect of nonnutritive sweeteners on cardiometabolic health: a potentially overlooked factor. CMAJ, 189(46), E1427. Accessed April 19, 2024. https://doi.org/10.1503/cmaj.733416.
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Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies
Meghan B. Azad, Ahmed M. Abou-Setta, Bhupendrasinh F. Chauhan, Rasheda Rabbani, Justin Lys, Leslie Copstein, Amrinder Mann, Maya M. Jeyaraman, Ashleigh E. Reid, Michelle Fiander, Dylan S. MacKay, Jon McGavock, Brandy Wicklow, Ryan Zarychanski
CMAJ Jul 2017, 189 (28) E929-E939; DOI: 10.1503/cmaj.161390
Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies
Meghan B. Azad, Ahmed M. Abou-Setta, Bhupendrasinh F. Chauhan, Rasheda Rabbani, Justin Lys, Leslie Copstein, Amrinder Mann, Maya M. Jeyaraman, Ashleigh E. Reid, Michelle Fiander, Dylan S. MacKay, Jon McGavock, Brandy Wicklow, Ryan Zarychanski
CMAJ Jul 2017, 189 (28) E929-E939; DOI: 10.1503/cmaj.161390
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- The importance of study design in the assessment of nonnutritive sweeteners and cardiometabolic health
- The timing of ingestion may influence the effect of nonnutritive sweeteners on cardiometabolic health: a potentially overlooked factor