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Research

Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies

Meghan B. Azad, Ahmed M. Abou-Setta, Bhupendrasinh F. Chauhan, Rasheda Rabbani, Justin Lys, Leslie Copstein, Amrinder Mann, Maya M. Jeyaraman, Ashleigh E. Reid, Michelle Fiander, Dylan S. MacKay, Jon McGavock, Brandy Wicklow and Ryan Zarychanski
CMAJ July 17, 2017 189 (28) E929-E939; DOI: https://doi.org/10.1503/cmaj.161390
Meghan B. Azad
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
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  • For correspondence: meghan.azad@umanitoba.ca
Ahmed M. Abou-Setta
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
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Bhupendrasinh F. Chauhan
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
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Rasheda Rabbani
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
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Justin Lys
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
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Leslie Copstein
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
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Amrinder Mann
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
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Maya M. Jeyaraman
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
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Ashleigh E. Reid
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
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Michelle Fiander
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
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Dylan S. MacKay
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
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Jon McGavock
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
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Brandy Wicklow
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
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Ryan Zarychanski
George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
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Article Information

vol. 189 no. 28 E929-E939
DOI 
https://doi.org/10.1503/cmaj.161390
PubMed 
28716847
History 
  • Accepted March 10, 2017
  • Published online July 16, 2017.
Copyright & Usage 
© 2017 Canadian Medical Association or its licensors

Author Information

  1. Meghan B. Azad, PhD⇑,
  2. Ahmed M. Abou-Setta, MD, PhD,
  3. Bhupendrasinh F. Chauhan, MPharm, PhD,
  4. Rasheda Rabbani, PhD,
  5. Justin Lys, MD,
  6. Leslie Copstein, MD,
  7. Amrinder Mann, MD,
  8. Maya M. Jeyaraman, MD, PhD,
  9. Ashleigh E. Reid, MPAS,
  10. Michelle Fiander, MLIS,
  11. Dylan S. MacKay, PhD,
  12. Jon McGavock, PhD,
  13. Brandy Wicklow, MD, MSc,
  14. Ryan Zarychanski, MD, MSc
  1. George & Fay Yee Centre for Healthcare Innovation (Azad, Abou-Setta, Chauhan, Rabbani, Lys, Copstein, Mann, Jeyaraman, Fiander, Zarychanski); Children’s Hospital Research Institute of Manitoba (Azad, Chauhan, McGavock, Wicklow); Department of Pediatrics and Child Health (Azad, McGavock, Wicklow); Department of Community Health Sciences (Abou-Setta); College of Pharmacy (Chauhan); Max Rady College of Medicine (Reid); Department of Human Nutritional Sciences (Azad, MacKay); Department of Internal Medicine (Zarychanski), University of Manitoba; Department of Hematology and Medical Oncology, CancerCare Manitoba (Zarychan-ski), Winnipeg, Man.
  1. Correspondence to: Meghan Azad, meghan.azad{at}umanitoba.ca
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Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies
Meghan B. Azad, Ahmed M. Abou-Setta, Bhupendrasinh F. Chauhan, Rasheda Rabbani, Justin Lys, Leslie Copstein, Amrinder Mann, Maya M. Jeyaraman, Ashleigh E. Reid, Michelle Fiander, Dylan S. MacKay, Jon McGavock, Brandy Wicklow, Ryan Zarychanski
CMAJ Jul 2017, 189 (28) E929-E939; DOI: 10.1503/cmaj.161390

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Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies
Meghan B. Azad, Ahmed M. Abou-Setta, Bhupendrasinh F. Chauhan, Rasheda Rabbani, Justin Lys, Leslie Copstein, Amrinder Mann, Maya M. Jeyaraman, Ashleigh E. Reid, Michelle Fiander, Dylan S. MacKay, Jon McGavock, Brandy Wicklow, Ryan Zarychanski
CMAJ Jul 2017, 189 (28) E929-E939; DOI: 10.1503/cmaj.161390
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