Research

Use of azithromycin and risk of ventricular arrhythmia

Gianluca Trifirò, Maria de Ridder, Janet Sultana, Alessandro Oteri, Peter Rijnbeek, Serena Pecchioli, Giampiero Mazzaglia, Irene Bezemer, Edeltraut Garbe, Tania Schink, Elisabetta Poluzzi, Trine Frøslev, Mariam Molokhia, Igor Diemberger and Miriam C.J.M. Sturkenboom
CMAJ April 18, 2017 189 (15) E560-E568; DOI: https://doi.org/10.1503/cmaj.160355

Article Figures & Tables

Figures

  • Figure 1:
    Figure 1:

    Selection of study cohort from 7 databases. AARHUS = Aarhus University Hospital Database, ERD = Emilia-Romagna Database, GePaRD = German Pharmacoepidemiological Research Database, HSD-CSD-LPD = Health Search Database Cegedim Strategic Data Longitudinal Patient Database, IPCI = Integrated Primary Care Information, PHARMO = PHARMO Database Network, THIN = The Health Improvement Network.

  • Figure 2:
    Figure 2:

    Database-specific risk of ventricular arrhythmia associated with current use of azithromycin compared with current use of amoxicillin (2-stage random-effects model). Values greater than 1.0 indicate an increased risk of ventricular arrhythmia with use of azithromycin (values plotted on logarithmic scale). Cochran Q = 0.08; p = 0.1; I2 = 51%. CI = confidence interval, OR = odds ratio. *Databases with fewer than 3 exposed cases were not included in the model.

  • Figure 3:
    Figure 3:

    Database-specific risk of ventricular arrhythmia associated with current use of azithromycin versus nonuse of antibiotics (2-stage random-effects model). Values greater than 1.0 indicate an increased risk of ventricular arrhythmia with use of azithromycin (values plotted on logarithmic scale). Cochran Q = 3.4; p = 0.3; I2 = 11.4%. CI = confidence interval, OR = odds ratio. *Databases with fewer than 3 exposed cases were not included in the model.

Tables

  • Table 1:

    Features of the databases included in the study

    Table 1:
  • Table 2:

    Demographic and clinical characteristics of ventricular arrhythmia cases and matched controls in an inception cohort of new users of antibiotics across all databases (1-stage pooling)

    Table 2:
  • Table 3:

    Risk of ventricular arrhythmia associated with current, recent and past use of azithromycin compared with current use of amoxicillin (1-stage pooling)

    Table 3:
  • Table 4:

    Risk of ventricular arrhythmia associated with current, recent and past use of azithromycin and other antibiotics compared with nonuse of antibiotics (1-stage pooling)

    Table 4:
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In this issue

Canadian Medical Association Journal: 189 (15)
CMAJ
Vol. 189, Issue 15
18 Apr 2017

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Use of azithromycin and risk of ventricular arrhythmia
Gianluca Trifirò, Maria de Ridder, Janet Sultana, Alessandro Oteri, Peter Rijnbeek, Serena Pecchioli, Giampiero Mazzaglia, Irene Bezemer, Edeltraut Garbe, Tania Schink, Elisabetta Poluzzi, Trine Frøslev, Mariam Molokhia, Igor Diemberger, Miriam C.J.M. Sturkenboom
CMAJ Apr 2017, 189 (15) E560-E568; DOI: 10.1503/cmaj.160355
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