Skip to main content

Main menu

  • Home
  • Content
    • Current issue
    • Past issues
    • Early releases
    • Collections
    • Sections
    • Blog
    • Infographics & illustrations
    • Podcasts
    • COVID-19 articles
    • Obituary notices
  • Authors & Reviewers
    • Overview for authors
    • Submission guidelines
    • Submit a manuscript
    • Forms
    • Editorial process
    • Editorial policies
    • Peer review process
    • Publication fees
    • Reprint requests
    • Open access
    • Patient engagement
  • Physicians & Subscribers
    • Benefits for Canadian physicians
    • CPD Credits for CMA Members
    • Subscribe to CMAJ Print
    • Subscription prices
    • Obituary notices
  • Alerts
    • Email alerts
    • RSS
  • JAMC
    • À propos
    • Numéro en cours
    • Archives
    • Sections
    • Abonnement
    • Alertes
    • Trousse média 2023
    • Avis de décès
  • CMAJ JOURNALS
    • CMAJ Open
    • CJS
    • JAMC
    • JPN

User menu

Search

  • Advanced search
CMAJ
  • CMAJ JOURNALS
    • CMAJ Open
    • CJS
    • JAMC
    • JPN
CMAJ

Advanced Search

  • Home
  • Content
    • Current issue
    • Past issues
    • Early releases
    • Collections
    • Sections
    • Blog
    • Infographics & illustrations
    • Podcasts
    • COVID-19 articles
    • Obituary notices
  • Authors & Reviewers
    • Overview for authors
    • Submission guidelines
    • Submit a manuscript
    • Forms
    • Editorial process
    • Editorial policies
    • Peer review process
    • Publication fees
    • Reprint requests
    • Open access
    • Patient engagement
  • Physicians & Subscribers
    • Benefits for Canadian physicians
    • CPD Credits for CMA Members
    • Subscribe to CMAJ Print
    • Subscription prices
    • Obituary notices
  • Alerts
    • Email alerts
    • RSS
  • JAMC
    • À propos
    • Numéro en cours
    • Archives
    • Sections
    • Abonnement
    • Alertes
    • Trousse média 2023
    • Avis de décès
  • Visit CMAJ on Facebook
  • Follow CMAJ on Twitter
  • Follow CMAJ on Instagram
  • Listen to CMAJ podcasts
Commentary

Naming and classifying old and new ECG phenomena

Adrian Baranchuk and Antoni Bayés-Genis
CMAJ April 19, 2016 188 (7) 485-486; DOI: https://doi.org/10.1503/cmaj.151209
Adrian Baranchuk
Division of Cardiology (Baranchuk), Queen’s University, Kingston, Ont.; Servicio de Cardiologia (Bayés-Genis), Hospital Germans Trias I Pujol, Badalona, Catalunya, Spain
MD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: [email protected]
Antoni Bayés-Genis
Division of Cardiology (Baranchuk), Queen’s University, Kingston, Ont.; Servicio de Cardiologia (Bayés-Genis), Hospital Germans Trias I Pujol, Badalona, Catalunya, Spain
MD PhD
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Tables
  • Responses
  • Metrics
  • PDF
Loading

See also pages 528, 529, www.cmaj.ca/lookup/doi/10.1503/cmaj.150816 and www.cmaj.ca/lookup/doi/10.1503/cmaj.150550

Two linked reports present cases of atypical electrocardiography (ECG) patterns that represent manifestations of severe narrowing or occlusion of the proximal left anterior descending coronary artery.1,2 These ECG patterns, named after Wellens and de Winter, respectively, occasionally replace the classic ECG manifestations of ST-elevation myocardial infarction (STEMI). Initially described in 19823 and 2008,4 respectively, both correspond to proximal severe disease of the left anterior descending artery, with rapid recognition and intervention being required to ensure revascularization.

Certain commonalities in the clinical presentation, ECG evolution and required treatment lead us to believe that these ECG patterns may correspond to different manifestations of a single spectrum (Box 1).3,4 The differences between the two patterns may reflect the timing of ECG relative to total occlusion of the vessel, spontaneous reperfusion of the vessel, initiation of the ischemic process or resolution of the ischemic process. Recognizing the two patterns can help physicians to make correct and timely medical decisions, so as to rescue as much myocardium as possible. However, some inconsistencies have been noted in the literature, and these are reflected in the linked cases.1,2

Box 1: Characteristics of Wellens syndrome and de Winter syndrome3,4
CharacteristicWellens syndromede Winter syndrome
Prevalence as a STEMI equivalent, %182
Chest painIntermittentPresent
TroponinSlightly elevated or normalElevated
ST segment in precordial leadsSlightly elevatedDepressed
Preferential precordial leadsV1–V6V2–V4
T-wave characteristicsProfoundly negative or biphasic and symmetricPositive and symmetric (hyperacute T waves)
T-wave morphologyAbrupt take-off of the negative T wave from V2 to V4Ascending limb of the T wave commencing below the isoelectric baseline
Precordial R-wave progressionNormalNormal
Pathologic Q wavesNoNo
ST-segment elevation in lead aVRNoYes
Angiographic findingsCritical narrowing of proximal LADOcclusion of proximal LAD
Evolution of the ECG patternMay evolve into “classic” STEMI within weeksStable or evolving into “classic” STEMI
  • Note: ECG = electrocardiography, LAD = left anterior descending artery, STEMI = ST-segment elevation myocardial infarction.

These cases raise several questions: Are these true syndromes or simply ECG signs? Are they STEMI equivalents? Must all named ECG signs be present to use the term “Wellens syndrome” (or pattern) or “de Winter syndrome” (or pattern)? What distinguishes an ECG sign from a syndrome? These are not just semantic questions; rather, they are related to both medical knowledge and knowledge translation.

A syndrome should have both signs (e.g., the characteristic ECG pattern) and symptoms (e.g., chest pain). If the patient is pain-free at the time of evaluation, the physician should ask about prior history of angina to recognize one of these syndromes. Definitions that use terms such as “slight elevation” or “slight depression” are difficult to universalize; conversely, definitions that include “0.5-mV elevation or depression” can be difficult to measure and quantify. Finally, if a series of ECG signs must be present to define an ECG phenomenon, is the presence of only one or two of the signs enough to confirm the phenomenon? For example, in Wellens syndrome, lead aVR should show ST-segment elevation. However, in the case presented by Das and Almajed,1 lead aVR was not elevated. Similarly, in de Winter syndrome, the total occlusion should occur in the proximal left anterior descending artery; however, in the case presented by Martínez-Losas and Fernández-Jiménez,2 the occlusion occurred after the first septal perforator, which indicates occlusion of the mid-third of the vessel. How strict should the definitions be for defining a new ECG phenomenon, and how strict should clinicians be in determining that particular cases belong to weakly defined syndromes?

In thinking about the inclusion of an ECG phenomenon in the literature, an example that comes to mind is Brugada syndrome,5 a rare genetic disease associated with sudden death in patients with apparently normal heart structure. The surface ECG remains the key to the diagnosis. Three different patterns were described initially, but the third pattern was removed from the definition in 2012. Despite their completely different morphologies, the two remaining types are simply called types 1 and 2. The distinction between them is universally accepted, and thousands of papers can be found that address this rare genetic disorder.

The example of Brugada syndrome suggests that two distinctive patterns corresponding to the same physiopathologic origin (i.e., occlusion or severe narrowing of the proximal left anterior descending artery) should not be named differently, given that the authors describing the patterns belong to the same academic group. It would be easier to learn and to teach these patterns if, for example, the phenomena were to be called Wellens ECG patterns 1 and 2. In fact, the de Winter ECG phenomenon was named after the first author of a report of a relatively small series of 30 patients. If this were the general rule for such observations, clinicians would have to remember the names of more than 100 new ECG phenomena reported in the past decade, which would be impractical.

For an ECG phenomenon to gain universal recognition deserving of an eponym in the literature, we suggest that the following conditions should apply.

First, there should be multiple independent reports (i.e., visibility). The phenomenon in question should be seen, recognized and reported by several groups, preferably internationally. There will be a period when the terminology is inconsistent, until multiple reports of the phenomenon have appeared and practitioners in the field can agree on an appropriate name. One example is early repolarization syndrome, which has also been termed early repolarization pattern, early repolarization variant and Haïssaguerre syndrome.

Second, a clear physiopathologic basis should be apparent. It is clear that the common pathway for both syndromes reported in the linked articles is severe narrowing or total occlusion of the proximal left anterior descending artery; however, there is little speculation in the literature about why the ECG patterns are so distinctive. Specifically, how can the electrical activity of the heart and, more specifically, its repolarization differ so much from one pattern to another? Is it a marker of the disorder’s evolution or an indication of reperfusion? This requires further exploration.

Third, clinical reproducibility should be demonstrable, on the basis of careful investigation. For example, one would expect that, in cases in which the left anterior descending artery is occluded proximally and the ECG depicts the de Winter pattern, the pattern should reappear if the artery is opened and subsequently becomes re-occluded. Such a scenario is not rare in the context of acute coronary syndromes, so a review is needed of all Wellens and de Winter cases to check for reoccurrence of the pattern upon re-occlusion.

Fourth, experimental models should be established. Several animal models of ischemia exist, but a model suitable for reproduction of these phenomena is lacking. An experimental model would help advance knowledge and would allow better discussion of the temporal relation of the ECG phenomenon to the occlusion or to the initiation of myocardial ischemia.

In conclusion, we call for a systematic approach to the naming and inclusion of new ECG phenomena in the already extensive literature.

Key points
  • The electrocardiographic patterns of Wellens syndrome and de Winter syndrome should be recognized promptly as possible presentations of acute coronary syndromes, to allow for timely investigation and revascularization of the proximal left anterior descending coronary artery.

  • A systematic approach for development of new electrocardiographic terminology and eponyms is suggested to optimize learning and teaching strategies and to facilitate consistency in the literature.

Footnotes

  • Competing interests: Adrian Baranchuk has received unrestricted grants from Medtronic and Bayer and has received speaker’s honoraria from Medtronic, Bayer, Boehringer Ingelheim and Pfizer. No other competing interests were declared.

  • This article was solicited and has not been peer reviewed.

  • Contributors: Adrian Baranchuk conceived the article, wrote the first draft, suggested references and revised the final draft. Antoni Bayés-Genis conceived the article; supervised, modified and corrected the first draft; and wrote the second and final drafts. Both of the authors approved the final version for publication and agreed to act as guarantors of the work.

References

  1. ↵
    1. Das D,
    2. Almajed NS
    . Wellens syndrome. CMAJ 2016;188:529.
    OpenUrlFREE Full Text
  2. ↵
    1. Martínez-Losas P,
    2. Fernández-Jiménez R
    . de Winter syndrome. CMAJ 2016;188:528.
    OpenUrlFREE Full Text
  3. ↵
    1. de Zwaan C,
    2. Bär FW,
    3. Wellens HJ
    . Characteristic electrocardiographic pattern indicating critical stenosis high in left anterior descending coronary artery in patients admitted because of impending myocardial infarction. Am Heart J 1982;103:730–6.
    OpenUrlCrossRefPubMed
  4. ↵
    1. de Winter RJ,
    2. Verouden N,
    3. Wellens H,
    4. et al
    . A new ECG sign of proximal LAD occlusion. N Engl J Med 2008;359:2071–3.
    OpenUrlCrossRefPubMed
  5. ↵
    1. Bayés de Luna A,
    2. Brugada J,
    3. Baranchuk A,
    4. et al
    . Current electrocardiographic criteria for diagnosis of Brugada pattern: a consensus document. J Electrocardiol 2012;45:433–42.
    OpenUrlCrossRefPubMed
PreviousNext
Back to top

In this issue

Canadian Medical Association Journal: 188 (7)
CMAJ
Vol. 188, Issue 7
19 Apr 2016
  • Table of Contents
  • Index by author

Article tools

Respond to this article
Print
Download PDF
Article Alerts
To sign up for email alerts or to access your current email alerts, enter your email address below:
Email Article

Thank you for your interest in spreading the word on CMAJ.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Naming and classifying old and new ECG phenomena
(Your Name) has sent you a message from CMAJ
(Your Name) thought you would like to see the CMAJ web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Naming and classifying old and new ECG phenomena
Adrian Baranchuk, Antoni Bayés-Genis
CMAJ Apr 2016, 188 (7) 485-486; DOI: 10.1503/cmaj.151209

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
‍ Request Permissions
Share
Naming and classifying old and new ECG phenomena
Adrian Baranchuk, Antoni Bayés-Genis
CMAJ Apr 2016, 188 (7) 485-486; DOI: 10.1503/cmaj.151209
Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like

Jump to section

  • Article
    • Footnotes
    • References
  • Figures & Tables
  • Responses
  • Metrics
  • PDF

Related Articles

  • de Winter syndrome
  • Wellens syndrome
  • Highlights
  • PubMed
  • Google Scholar

Cited By...

  • No citing articles found.
  • Google Scholar

More in this TOC Section

  • How can Canada’s health systems improve care for people with chronic obstructive pulmonary disease?
  • Minimally invasive procedures in gender-affirming care: the case for public funding across Canada
  • Time for Canada to align with global innovations in treatment for tuberculosis
Show more Commentary

Similar Articles

Collections

  • Topics
    • Cardiology: ischemic heart disease
    • Emergency medicine

 

View Latest Classified Ads

Content

  • Current issue
  • Past issues
  • Collections
  • Sections
  • Blog
  • Podcasts
  • Alerts
  • RSS
  • Early releases

Information for

  • Advertisers
  • Authors
  • Reviewers
  • CMA Members
  • CPD credits
  • Media
  • Reprint requests
  • Subscribers

About

  • General Information
  • Journal staff
  • Editorial Board
  • Advisory Panels
  • Governance Council
  • Journal Oversight
  • Careers
  • Contact
  • Copyright and Permissions
CMAJ Group

Copyright 2023, CMA Impact Inc. or its licensors. All rights reserved. ISSN 1488-2329 (e) 0820-3946 (p)

All editorial matter in CMAJ represents the opinions of the authors and not necessarily those of the Canadian Medical Association or its subsidiaries.

To receive any of these resources in an accessible format, please contact us at CMAJ Group, 500-1410 Blair Towers Place, Ottawa ON, K1J 9B9; p: 1-888-855-2555; e: [email protected]

CMA Civility, Accessibility, Privacy

 

Powered by HighWire