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Treatment Mechanism of action Recommended dosage Relative cost Soluble fibre (e.g., psyllium) Bulking agent 6–12 g/d $ PEG 3350 Osmotic 17 g/d in water $$ Lactulose Osmotic 15–30 mL/d $$ Stimulant laxative (e.g., bisacodyl) Motility stimulant 10 mg as needed $$ Prucalopride Prokinetic 2 mg/d $$$ Linaclotide Guanylate cyclase C agonist 145 μg/d for chronic constipation $$$ 290 μg/d for IBS with constipation $$$$ Note: IBS = inflammatory bowel syndrome, PEG = polyethylene glycol.
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