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Direct oral anticoagulants and the bleeding patient
Brendan Wood, Michelle Sholzberg and Alun Ackery
CMAJ February 16, 2016 188 (3) 215; DOI: https://doi.org/10.1503/cmaj.150604
Brendan Wood
Division of Emergency Medicine (Wood, Ackery) and Division of Hematology (Sholzberg), Department of Medicine, University of Toronto; Division of Hematopathology (Sholzberg), Coagulation Laboratory and Pathobiology, Department of Laboratory Medicine, University of Toronto; and St. Michael’s Hospital (Ackery, Sholzberg), Toronto, Ont.
Michelle Sholzberg
Division of Emergency Medicine (Wood, Ackery) and Division of Hematology (Sholzberg), Department of Medicine, University of Toronto; Division of Hematopathology (Sholzberg), Coagulation Laboratory and Pathobiology, Department of Laboratory Medicine, University of Toronto; and St. Michael’s Hospital (Ackery, Sholzberg), Toronto, Ont.
Alun Ackery
Division of Emergency Medicine (Wood, Ackery) and Division of Hematology (Sholzberg), Department of Medicine, University of Toronto; Division of Hematopathology (Sholzberg), Coagulation Laboratory and Pathobiology, Department of Laboratory Medicine, University of Toronto; and St. Michael’s Hospital (Ackery, Sholzberg), Toronto, Ont.
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Direct oral anticoagulants and the bleeding patient
Brendan Wood, Michelle Sholzberg, Alun Ackery
CMAJ Feb 2016, 188 (3) 215; DOI: 10.1503/cmaj.150604
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- Direct oral anticoagulant agents are now routinely used for the prevention of stroke in nonvalvular atrial fibrillation
- Risk of bleeding with direct oral anticoagulants is lower than with vitamin K antagonists, but varies by site
- Direct oral anticoagulants are characterized by rapid onset of action and short half-lives2
- Direct oral anticoagulants variably affect standard clot-based assays
- Idarucizumab has recently been approved by the US Food and Drug Administration to reverse the activity of dabigatran
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