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Practice

Flumazenil in benzodiazepine overdose

Howard An and Jesse Godwin
CMAJ December 06, 2016 188 (17-18) E537; DOI: https://doi.org/10.1503/cmaj.160357
Howard An
Divisions of Emergency Medicine (Godwin) and Clinical Pharmacology and Toxicology (An, Godwin), Department of Medicine, University of Toronto; Ontario Poison Centre (An, Godwin), Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ont.
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  • For correspondence: howard.an@gmail.com
Jesse Godwin
Divisions of Emergency Medicine (Godwin) and Clinical Pharmacology and Toxicology (An, Godwin), Department of Medicine, University of Toronto; Ontario Poison Centre (An, Godwin), Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ont.
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Article Information

vol. 188 no. 17-18 E537
DOI 
https://doi.org/10.1503/cmaj.160357
PubMed 
27920113
History 
  • Published online December 5, 2016.

Article Versions

  • Latest version (November 14, 2016 - 08:46).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2016 Joule Inc. or its licensors

Author Information

  1. Howard An, MD MSc⇑,
  2. Jesse Godwin, MD
  1. Divisions of Emergency Medicine (Godwin) and Clinical Pharmacology and Toxicology (An, Godwin), Department of Medicine, University of Toronto; Ontario Poison Centre (An, Godwin), Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, Toronto, Ont.
  1. Correspondence to: Howard An, howard.an{at}gmail.com

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Canadian Medical Association Journal: 188 (17-18)
CMAJ
Vol. 188, Issue 17-18
6 Dec 2016
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Flumazenil in benzodiazepine overdose
Howard An, Jesse Godwin
CMAJ Dec 2016, 188 (17-18) E537; DOI: 10.1503/cmaj.160357

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Flumazenil in benzodiazepine overdose
Howard An, Jesse Godwin
CMAJ Dec 2016, 188 (17-18) E537; DOI: 10.1503/cmaj.160357
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    • Isolated benzodiazepine overdoses are rarely fatal
    • Flumazenil antagonizes benzodiazepine activity
    • Flumazenil should not be used routinely
    • Select patients may benefit from the administration of flumazenil
    • Flumazenil has a short half-life
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