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Research

Do clinicians understand the size of treatment effects? A randomized survey across 8 countries

Bradley C. Johnston, Pablo Alonso-Coello, Jan O. Friedrich, Reem A. Mustafa, Kari A.O. Tikkinen, Ignacio Neumann, Per O. Vandvik, Elie A. Akl, Bruno R. da Costa, Neill K. Adhikari, Gemma Mas Dalmau, Elise Kosunen, Jukka Mustonen, Mark W. Crawford, Lehana Thabane and Gordon H. Guyatt
CMAJ January 05, 2016 188 (1) 25-32; DOI: https://doi.org/10.1503/cmaj.150430
Bradley C. Johnston
Department of Anesthesia and Pain Medicine (Johnston, Crawford), The Hospital for Sick Children, University of Toronto, Toronto, Ont.; Institute of Health Policy, Management and Evaluation (Johnston), Dalla Lana School of Public Health, University of Toronto, Toronto, Ont.; Child Health Evaluative Sciences (Johnston), The Hospital for Sick Children Research Institute, Toronto, Ont.; Iberoamerican Cochrane Center (Alonso-Coello, Dalmau), Biomedical Research Institute Sant Pau, CIBER Epidemiologiay Salud Publica, Barcelona, Spain; Departments of Critical Care and Medicine (Friedrich), St. Michael’s Hospital, Toronto, Ont.; Department of Medicine and Interdepartmental Division of Critical Care (Friedrich), University of Toronto, Toronto, Ont.; Departments of Medicine and Biomedical and Health Informatics (Mustafa), University of Missouri–Kansas City, Kansas City, Mo.; Department of Clinical Epidemiology and Biostatistics (Mustafa, Tikkinen, Neumann, Akl, Thabane, Guyatt), McMaster University, Hamilton, Ont.; Departments of Urology and Public Health (Tikkinen), Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland; Department of Internal Medicine (Neumann), Pontificia Universidad Catolica de Chile, Santiago, Chile; Institute of Health and Society (Vandvik), Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Medicine (Vandvik), Innlandet Hospital Trust, Division Gjövik, Norway; Clinical Epidemiology Unit (Akl), American University of Beirut, Beirut, Lebanon; Institute of Primary Health Care (da Costa), University of Bern, Bern, Switzerland; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari), Sunnybrook Health Sciences Centre, Toronto, Ont.; Interdepartmental Division of Critical Care (Adhikari), University of Toronto, Toronto, Ont.; School of Medicine and Centre for General Practice (Kosunen), University of Tampere and Pirkanmaa Hospital District, Tampere, Finland; School of Medicine and Department of Internal Medicine (Mustonen), University of Tampere and Tampere University Hospital, Tampere, Finland; Physiology and Experimental Medicine (Crawford), The Hospital for Sick Children Research Institute, Toronto, Ont.; Biostatistics Unit of the Centre for Evaluation of Medicines (Thabane), McMaster University, Hamilton, Ont.; Population Health Research Unit, Hamilton Health Sciences (Thabane), McMaster University, Hamilton, Ont.; Department of Medicine (Guyatt), McMaster University, Hamilton, Ont.
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  • For correspondence: bradley.johnston@sickkids.ca
Pablo Alonso-Coello
Department of Anesthesia and Pain Medicine (Johnston, Crawford), The Hospital for Sick Children, University of Toronto, Toronto, Ont.; Institute of Health Policy, Management and Evaluation (Johnston), Dalla Lana School of Public Health, University of Toronto, Toronto, Ont.; Child Health Evaluative Sciences (Johnston), The Hospital for Sick Children Research Institute, Toronto, Ont.; Iberoamerican Cochrane Center (Alonso-Coello, Dalmau), Biomedical Research Institute Sant Pau, CIBER Epidemiologiay Salud Publica, Barcelona, Spain; Departments of Critical Care and Medicine (Friedrich), St. Michael’s Hospital, Toronto, Ont.; Department of Medicine and Interdepartmental Division of Critical Care (Friedrich), University of Toronto, Toronto, Ont.; Departments of Medicine and Biomedical and Health Informatics (Mustafa), University of Missouri–Kansas City, Kansas City, Mo.; Department of Clinical Epidemiology and Biostatistics (Mustafa, Tikkinen, Neumann, Akl, Thabane, Guyatt), McMaster University, Hamilton, Ont.; Departments of Urology and Public Health (Tikkinen), Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland; Department of Internal Medicine (Neumann), Pontificia Universidad Catolica de Chile, Santiago, Chile; Institute of Health and Society (Vandvik), Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Medicine (Vandvik), Innlandet Hospital Trust, Division Gjövik, Norway; Clinical Epidemiology Unit (Akl), American University of Beirut, Beirut, Lebanon; Institute of Primary Health Care (da Costa), University of Bern, Bern, Switzerland; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari), Sunnybrook Health Sciences Centre, Toronto, Ont.; Interdepartmental Division of Critical Care (Adhikari), University of Toronto, Toronto, Ont.; School of Medicine and Centre for General Practice (Kosunen), University of Tampere and Pirkanmaa Hospital District, Tampere, Finland; School of Medicine and Department of Internal Medicine (Mustonen), University of Tampere and Tampere University Hospital, Tampere, Finland; Physiology and Experimental Medicine (Crawford), The Hospital for Sick Children Research Institute, Toronto, Ont.; Biostatistics Unit of the Centre for Evaluation of Medicines (Thabane), McMaster University, Hamilton, Ont.; Population Health Research Unit, Hamilton Health Sciences (Thabane), McMaster University, Hamilton, Ont.; Department of Medicine (Guyatt), McMaster University, Hamilton, Ont.
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Jan O. Friedrich
Department of Anesthesia and Pain Medicine (Johnston, Crawford), The Hospital for Sick Children, University of Toronto, Toronto, Ont.; Institute of Health Policy, Management and Evaluation (Johnston), Dalla Lana School of Public Health, University of Toronto, Toronto, Ont.; Child Health Evaluative Sciences (Johnston), The Hospital for Sick Children Research Institute, Toronto, Ont.; Iberoamerican Cochrane Center (Alonso-Coello, Dalmau), Biomedical Research Institute Sant Pau, CIBER Epidemiologiay Salud Publica, Barcelona, Spain; Departments of Critical Care and Medicine (Friedrich), St. Michael’s Hospital, Toronto, Ont.; Department of Medicine and Interdepartmental Division of Critical Care (Friedrich), University of Toronto, Toronto, Ont.; Departments of Medicine and Biomedical and Health Informatics (Mustafa), University of Missouri–Kansas City, Kansas City, Mo.; Department of Clinical Epidemiology and Biostatistics (Mustafa, Tikkinen, Neumann, Akl, Thabane, Guyatt), McMaster University, Hamilton, Ont.; Departments of Urology and Public Health (Tikkinen), Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland; Department of Internal Medicine (Neumann), Pontificia Universidad Catolica de Chile, Santiago, Chile; Institute of Health and Society (Vandvik), Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Medicine (Vandvik), Innlandet Hospital Trust, Division Gjövik, Norway; Clinical Epidemiology Unit (Akl), American University of Beirut, Beirut, Lebanon; Institute of Primary Health Care (da Costa), University of Bern, Bern, Switzerland; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari), Sunnybrook Health Sciences Centre, Toronto, Ont.; Interdepartmental Division of Critical Care (Adhikari), University of Toronto, Toronto, Ont.; School of Medicine and Centre for General Practice (Kosunen), University of Tampere and Pirkanmaa Hospital District, Tampere, Finland; School of Medicine and Department of Internal Medicine (Mustonen), University of Tampere and Tampere University Hospital, Tampere, Finland; Physiology and Experimental Medicine (Crawford), The Hospital for Sick Children Research Institute, Toronto, Ont.; Biostatistics Unit of the Centre for Evaluation of Medicines (Thabane), McMaster University, Hamilton, Ont.; Population Health Research Unit, Hamilton Health Sciences (Thabane), McMaster University, Hamilton, Ont.; Department of Medicine (Guyatt), McMaster University, Hamilton, Ont.
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Reem A. Mustafa
Department of Anesthesia and Pain Medicine (Johnston, Crawford), The Hospital for Sick Children, University of Toronto, Toronto, Ont.; Institute of Health Policy, Management and Evaluation (Johnston), Dalla Lana School of Public Health, University of Toronto, Toronto, Ont.; Child Health Evaluative Sciences (Johnston), The Hospital for Sick Children Research Institute, Toronto, Ont.; Iberoamerican Cochrane Center (Alonso-Coello, Dalmau), Biomedical Research Institute Sant Pau, CIBER Epidemiologiay Salud Publica, Barcelona, Spain; Departments of Critical Care and Medicine (Friedrich), St. Michael’s Hospital, Toronto, Ont.; Department of Medicine and Interdepartmental Division of Critical Care (Friedrich), University of Toronto, Toronto, Ont.; Departments of Medicine and Biomedical and Health Informatics (Mustafa), University of Missouri–Kansas City, Kansas City, Mo.; Department of Clinical Epidemiology and Biostatistics (Mustafa, Tikkinen, Neumann, Akl, Thabane, Guyatt), McMaster University, Hamilton, Ont.; Departments of Urology and Public Health (Tikkinen), Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland; Department of Internal Medicine (Neumann), Pontificia Universidad Catolica de Chile, Santiago, Chile; Institute of Health and Society (Vandvik), Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Medicine (Vandvik), Innlandet Hospital Trust, Division Gjövik, Norway; Clinical Epidemiology Unit (Akl), American University of Beirut, Beirut, Lebanon; Institute of Primary Health Care (da Costa), University of Bern, Bern, Switzerland; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari), Sunnybrook Health Sciences Centre, Toronto, Ont.; Interdepartmental Division of Critical Care (Adhikari), University of Toronto, Toronto, Ont.; School of Medicine and Centre for General Practice (Kosunen), University of Tampere and Pirkanmaa Hospital District, Tampere, Finland; School of Medicine and Department of Internal Medicine (Mustonen), University of Tampere and Tampere University Hospital, Tampere, Finland; Physiology and Experimental Medicine (Crawford), The Hospital for Sick Children Research Institute, Toronto, Ont.; Biostatistics Unit of the Centre for Evaluation of Medicines (Thabane), McMaster University, Hamilton, Ont.; Population Health Research Unit, Hamilton Health Sciences (Thabane), McMaster University, Hamilton, Ont.; Department of Medicine (Guyatt), McMaster University, Hamilton, Ont.
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Kari A.O. Tikkinen
Department of Anesthesia and Pain Medicine (Johnston, Crawford), The Hospital for Sick Children, University of Toronto, Toronto, Ont.; Institute of Health Policy, Management and Evaluation (Johnston), Dalla Lana School of Public Health, University of Toronto, Toronto, Ont.; Child Health Evaluative Sciences (Johnston), The Hospital for Sick Children Research Institute, Toronto, Ont.; Iberoamerican Cochrane Center (Alonso-Coello, Dalmau), Biomedical Research Institute Sant Pau, CIBER Epidemiologiay Salud Publica, Barcelona, Spain; Departments of Critical Care and Medicine (Friedrich), St. Michael’s Hospital, Toronto, Ont.; Department of Medicine and Interdepartmental Division of Critical Care (Friedrich), University of Toronto, Toronto, Ont.; Departments of Medicine and Biomedical and Health Informatics (Mustafa), University of Missouri–Kansas City, Kansas City, Mo.; Department of Clinical Epidemiology and Biostatistics (Mustafa, Tikkinen, Neumann, Akl, Thabane, Guyatt), McMaster University, Hamilton, Ont.; Departments of Urology and Public Health (Tikkinen), Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland; Department of Internal Medicine (Neumann), Pontificia Universidad Catolica de Chile, Santiago, Chile; Institute of Health and Society (Vandvik), Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Medicine (Vandvik), Innlandet Hospital Trust, Division Gjövik, Norway; Clinical Epidemiology Unit (Akl), American University of Beirut, Beirut, Lebanon; Institute of Primary Health Care (da Costa), University of Bern, Bern, Switzerland; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari), Sunnybrook Health Sciences Centre, Toronto, Ont.; Interdepartmental Division of Critical Care (Adhikari), University of Toronto, Toronto, Ont.; School of Medicine and Centre for General Practice (Kosunen), University of Tampere and Pirkanmaa Hospital District, Tampere, Finland; School of Medicine and Department of Internal Medicine (Mustonen), University of Tampere and Tampere University Hospital, Tampere, Finland; Physiology and Experimental Medicine (Crawford), The Hospital for Sick Children Research Institute, Toronto, Ont.; Biostatistics Unit of the Centre for Evaluation of Medicines (Thabane), McMaster University, Hamilton, Ont.; Population Health Research Unit, Hamilton Health Sciences (Thabane), McMaster University, Hamilton, Ont.; Department of Medicine (Guyatt), McMaster University, Hamilton, Ont.
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Ignacio Neumann
Department of Anesthesia and Pain Medicine (Johnston, Crawford), The Hospital for Sick Children, University of Toronto, Toronto, Ont.; Institute of Health Policy, Management and Evaluation (Johnston), Dalla Lana School of Public Health, University of Toronto, Toronto, Ont.; Child Health Evaluative Sciences (Johnston), The Hospital for Sick Children Research Institute, Toronto, Ont.; Iberoamerican Cochrane Center (Alonso-Coello, Dalmau), Biomedical Research Institute Sant Pau, CIBER Epidemiologiay Salud Publica, Barcelona, Spain; Departments of Critical Care and Medicine (Friedrich), St. Michael’s Hospital, Toronto, Ont.; Department of Medicine and Interdepartmental Division of Critical Care (Friedrich), University of Toronto, Toronto, Ont.; Departments of Medicine and Biomedical and Health Informatics (Mustafa), University of Missouri–Kansas City, Kansas City, Mo.; Department of Clinical Epidemiology and Biostatistics (Mustafa, Tikkinen, Neumann, Akl, Thabane, Guyatt), McMaster University, Hamilton, Ont.; Departments of Urology and Public Health (Tikkinen), Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland; Department of Internal Medicine (Neumann), Pontificia Universidad Catolica de Chile, Santiago, Chile; Institute of Health and Society (Vandvik), Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Medicine (Vandvik), Innlandet Hospital Trust, Division Gjövik, Norway; Clinical Epidemiology Unit (Akl), American University of Beirut, Beirut, Lebanon; Institute of Primary Health Care (da Costa), University of Bern, Bern, Switzerland; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari), Sunnybrook Health Sciences Centre, Toronto, Ont.; Interdepartmental Division of Critical Care (Adhikari), University of Toronto, Toronto, Ont.; School of Medicine and Centre for General Practice (Kosunen), University of Tampere and Pirkanmaa Hospital District, Tampere, Finland; School of Medicine and Department of Internal Medicine (Mustonen), University of Tampere and Tampere University Hospital, Tampere, Finland; Physiology and Experimental Medicine (Crawford), The Hospital for Sick Children Research Institute, Toronto, Ont.; Biostatistics Unit of the Centre for Evaluation of Medicines (Thabane), McMaster University, Hamilton, Ont.; Population Health Research Unit, Hamilton Health Sciences (Thabane), McMaster University, Hamilton, Ont.; Department of Medicine (Guyatt), McMaster University, Hamilton, Ont.
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Per O. Vandvik
Department of Anesthesia and Pain Medicine (Johnston, Crawford), The Hospital for Sick Children, University of Toronto, Toronto, Ont.; Institute of Health Policy, Management and Evaluation (Johnston), Dalla Lana School of Public Health, University of Toronto, Toronto, Ont.; Child Health Evaluative Sciences (Johnston), The Hospital for Sick Children Research Institute, Toronto, Ont.; Iberoamerican Cochrane Center (Alonso-Coello, Dalmau), Biomedical Research Institute Sant Pau, CIBER Epidemiologiay Salud Publica, Barcelona, Spain; Departments of Critical Care and Medicine (Friedrich), St. Michael’s Hospital, Toronto, Ont.; Department of Medicine and Interdepartmental Division of Critical Care (Friedrich), University of Toronto, Toronto, Ont.; Departments of Medicine and Biomedical and Health Informatics (Mustafa), University of Missouri–Kansas City, Kansas City, Mo.; Department of Clinical Epidemiology and Biostatistics (Mustafa, Tikkinen, Neumann, Akl, Thabane, Guyatt), McMaster University, Hamilton, Ont.; Departments of Urology and Public Health (Tikkinen), Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland; Department of Internal Medicine (Neumann), Pontificia Universidad Catolica de Chile, Santiago, Chile; Institute of Health and Society (Vandvik), Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Medicine (Vandvik), Innlandet Hospital Trust, Division Gjövik, Norway; Clinical Epidemiology Unit (Akl), American University of Beirut, Beirut, Lebanon; Institute of Primary Health Care (da Costa), University of Bern, Bern, Switzerland; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari), Sunnybrook Health Sciences Centre, Toronto, Ont.; Interdepartmental Division of Critical Care (Adhikari), University of Toronto, Toronto, Ont.; School of Medicine and Centre for General Practice (Kosunen), University of Tampere and Pirkanmaa Hospital District, Tampere, Finland; School of Medicine and Department of Internal Medicine (Mustonen), University of Tampere and Tampere University Hospital, Tampere, Finland; Physiology and Experimental Medicine (Crawford), The Hospital for Sick Children Research Institute, Toronto, Ont.; Biostatistics Unit of the Centre for Evaluation of Medicines (Thabane), McMaster University, Hamilton, Ont.; Population Health Research Unit, Hamilton Health Sciences (Thabane), McMaster University, Hamilton, Ont.; Department of Medicine (Guyatt), McMaster University, Hamilton, Ont.
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Elie A. Akl
Department of Anesthesia and Pain Medicine (Johnston, Crawford), The Hospital for Sick Children, University of Toronto, Toronto, Ont.; Institute of Health Policy, Management and Evaluation (Johnston), Dalla Lana School of Public Health, University of Toronto, Toronto, Ont.; Child Health Evaluative Sciences (Johnston), The Hospital for Sick Children Research Institute, Toronto, Ont.; Iberoamerican Cochrane Center (Alonso-Coello, Dalmau), Biomedical Research Institute Sant Pau, CIBER Epidemiologiay Salud Publica, Barcelona, Spain; Departments of Critical Care and Medicine (Friedrich), St. Michael’s Hospital, Toronto, Ont.; Department of Medicine and Interdepartmental Division of Critical Care (Friedrich), University of Toronto, Toronto, Ont.; Departments of Medicine and Biomedical and Health Informatics (Mustafa), University of Missouri–Kansas City, Kansas City, Mo.; Department of Clinical Epidemiology and Biostatistics (Mustafa, Tikkinen, Neumann, Akl, Thabane, Guyatt), McMaster University, Hamilton, Ont.; Departments of Urology and Public Health (Tikkinen), Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland; Department of Internal Medicine (Neumann), Pontificia Universidad Catolica de Chile, Santiago, Chile; Institute of Health and Society (Vandvik), Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Medicine (Vandvik), Innlandet Hospital Trust, Division Gjövik, Norway; Clinical Epidemiology Unit (Akl), American University of Beirut, Beirut, Lebanon; Institute of Primary Health Care (da Costa), University of Bern, Bern, Switzerland; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari), Sunnybrook Health Sciences Centre, Toronto, Ont.; Interdepartmental Division of Critical Care (Adhikari), University of Toronto, Toronto, Ont.; School of Medicine and Centre for General Practice (Kosunen), University of Tampere and Pirkanmaa Hospital District, Tampere, Finland; School of Medicine and Department of Internal Medicine (Mustonen), University of Tampere and Tampere University Hospital, Tampere, Finland; Physiology and Experimental Medicine (Crawford), The Hospital for Sick Children Research Institute, Toronto, Ont.; Biostatistics Unit of the Centre for Evaluation of Medicines (Thabane), McMaster University, Hamilton, Ont.; Population Health Research Unit, Hamilton Health Sciences (Thabane), McMaster University, Hamilton, Ont.; Department of Medicine (Guyatt), McMaster University, Hamilton, Ont.
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Bruno R. da Costa
Department of Anesthesia and Pain Medicine (Johnston, Crawford), The Hospital for Sick Children, University of Toronto, Toronto, Ont.; Institute of Health Policy, Management and Evaluation (Johnston), Dalla Lana School of Public Health, University of Toronto, Toronto, Ont.; Child Health Evaluative Sciences (Johnston), The Hospital for Sick Children Research Institute, Toronto, Ont.; Iberoamerican Cochrane Center (Alonso-Coello, Dalmau), Biomedical Research Institute Sant Pau, CIBER Epidemiologiay Salud Publica, Barcelona, Spain; Departments of Critical Care and Medicine (Friedrich), St. Michael’s Hospital, Toronto, Ont.; Department of Medicine and Interdepartmental Division of Critical Care (Friedrich), University of Toronto, Toronto, Ont.; Departments of Medicine and Biomedical and Health Informatics (Mustafa), University of Missouri–Kansas City, Kansas City, Mo.; Department of Clinical Epidemiology and Biostatistics (Mustafa, Tikkinen, Neumann, Akl, Thabane, Guyatt), McMaster University, Hamilton, Ont.; Departments of Urology and Public Health (Tikkinen), Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland; Department of Internal Medicine (Neumann), Pontificia Universidad Catolica de Chile, Santiago, Chile; Institute of Health and Society (Vandvik), Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Medicine (Vandvik), Innlandet Hospital Trust, Division Gjövik, Norway; Clinical Epidemiology Unit (Akl), American University of Beirut, Beirut, Lebanon; Institute of Primary Health Care (da Costa), University of Bern, Bern, Switzerland; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari), Sunnybrook Health Sciences Centre, Toronto, Ont.; Interdepartmental Division of Critical Care (Adhikari), University of Toronto, Toronto, Ont.; School of Medicine and Centre for General Practice (Kosunen), University of Tampere and Pirkanmaa Hospital District, Tampere, Finland; School of Medicine and Department of Internal Medicine (Mustonen), University of Tampere and Tampere University Hospital, Tampere, Finland; Physiology and Experimental Medicine (Crawford), The Hospital for Sick Children Research Institute, Toronto, Ont.; Biostatistics Unit of the Centre for Evaluation of Medicines (Thabane), McMaster University, Hamilton, Ont.; Population Health Research Unit, Hamilton Health Sciences (Thabane), McMaster University, Hamilton, Ont.; Department of Medicine (Guyatt), McMaster University, Hamilton, Ont.
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Neill K. Adhikari
Department of Anesthesia and Pain Medicine (Johnston, Crawford), The Hospital for Sick Children, University of Toronto, Toronto, Ont.; Institute of Health Policy, Management and Evaluation (Johnston), Dalla Lana School of Public Health, University of Toronto, Toronto, Ont.; Child Health Evaluative Sciences (Johnston), The Hospital for Sick Children Research Institute, Toronto, Ont.; Iberoamerican Cochrane Center (Alonso-Coello, Dalmau), Biomedical Research Institute Sant Pau, CIBER Epidemiologiay Salud Publica, Barcelona, Spain; Departments of Critical Care and Medicine (Friedrich), St. Michael’s Hospital, Toronto, Ont.; Department of Medicine and Interdepartmental Division of Critical Care (Friedrich), University of Toronto, Toronto, Ont.; Departments of Medicine and Biomedical and Health Informatics (Mustafa), University of Missouri–Kansas City, Kansas City, Mo.; Department of Clinical Epidemiology and Biostatistics (Mustafa, Tikkinen, Neumann, Akl, Thabane, Guyatt), McMaster University, Hamilton, Ont.; Departments of Urology and Public Health (Tikkinen), Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland; Department of Internal Medicine (Neumann), Pontificia Universidad Catolica de Chile, Santiago, Chile; Institute of Health and Society (Vandvik), Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Medicine (Vandvik), Innlandet Hospital Trust, Division Gjövik, Norway; Clinical Epidemiology Unit (Akl), American University of Beirut, Beirut, Lebanon; Institute of Primary Health Care (da Costa), University of Bern, Bern, Switzerland; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari), Sunnybrook Health Sciences Centre, Toronto, Ont.; Interdepartmental Division of Critical Care (Adhikari), University of Toronto, Toronto, Ont.; School of Medicine and Centre for General Practice (Kosunen), University of Tampere and Pirkanmaa Hospital District, Tampere, Finland; School of Medicine and Department of Internal Medicine (Mustonen), University of Tampere and Tampere University Hospital, Tampere, Finland; Physiology and Experimental Medicine (Crawford), The Hospital for Sick Children Research Institute, Toronto, Ont.; Biostatistics Unit of the Centre for Evaluation of Medicines (Thabane), McMaster University, Hamilton, Ont.; Population Health Research Unit, Hamilton Health Sciences (Thabane), McMaster University, Hamilton, Ont.; Department of Medicine (Guyatt), McMaster University, Hamilton, Ont.
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Gemma Mas Dalmau
Department of Anesthesia and Pain Medicine (Johnston, Crawford), The Hospital for Sick Children, University of Toronto, Toronto, Ont.; Institute of Health Policy, Management and Evaluation (Johnston), Dalla Lana School of Public Health, University of Toronto, Toronto, Ont.; Child Health Evaluative Sciences (Johnston), The Hospital for Sick Children Research Institute, Toronto, Ont.; Iberoamerican Cochrane Center (Alonso-Coello, Dalmau), Biomedical Research Institute Sant Pau, CIBER Epidemiologiay Salud Publica, Barcelona, Spain; Departments of Critical Care and Medicine (Friedrich), St. Michael’s Hospital, Toronto, Ont.; Department of Medicine and Interdepartmental Division of Critical Care (Friedrich), University of Toronto, Toronto, Ont.; Departments of Medicine and Biomedical and Health Informatics (Mustafa), University of Missouri–Kansas City, Kansas City, Mo.; Department of Clinical Epidemiology and Biostatistics (Mustafa, Tikkinen, Neumann, Akl, Thabane, Guyatt), McMaster University, Hamilton, Ont.; Departments of Urology and Public Health (Tikkinen), Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland; Department of Internal Medicine (Neumann), Pontificia Universidad Catolica de Chile, Santiago, Chile; Institute of Health and Society (Vandvik), Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Medicine (Vandvik), Innlandet Hospital Trust, Division Gjövik, Norway; Clinical Epidemiology Unit (Akl), American University of Beirut, Beirut, Lebanon; Institute of Primary Health Care (da Costa), University of Bern, Bern, Switzerland; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari), Sunnybrook Health Sciences Centre, Toronto, Ont.; Interdepartmental Division of Critical Care (Adhikari), University of Toronto, Toronto, Ont.; School of Medicine and Centre for General Practice (Kosunen), University of Tampere and Pirkanmaa Hospital District, Tampere, Finland; School of Medicine and Department of Internal Medicine (Mustonen), University of Tampere and Tampere University Hospital, Tampere, Finland; Physiology and Experimental Medicine (Crawford), The Hospital for Sick Children Research Institute, Toronto, Ont.; Biostatistics Unit of the Centre for Evaluation of Medicines (Thabane), McMaster University, Hamilton, Ont.; Population Health Research Unit, Hamilton Health Sciences (Thabane), McMaster University, Hamilton, Ont.; Department of Medicine (Guyatt), McMaster University, Hamilton, Ont.
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Elise Kosunen
Department of Anesthesia and Pain Medicine (Johnston, Crawford), The Hospital for Sick Children, University of Toronto, Toronto, Ont.; Institute of Health Policy, Management and Evaluation (Johnston), Dalla Lana School of Public Health, University of Toronto, Toronto, Ont.; Child Health Evaluative Sciences (Johnston), The Hospital for Sick Children Research Institute, Toronto, Ont.; Iberoamerican Cochrane Center (Alonso-Coello, Dalmau), Biomedical Research Institute Sant Pau, CIBER Epidemiologiay Salud Publica, Barcelona, Spain; Departments of Critical Care and Medicine (Friedrich), St. Michael’s Hospital, Toronto, Ont.; Department of Medicine and Interdepartmental Division of Critical Care (Friedrich), University of Toronto, Toronto, Ont.; Departments of Medicine and Biomedical and Health Informatics (Mustafa), University of Missouri–Kansas City, Kansas City, Mo.; Department of Clinical Epidemiology and Biostatistics (Mustafa, Tikkinen, Neumann, Akl, Thabane, Guyatt), McMaster University, Hamilton, Ont.; Departments of Urology and Public Health (Tikkinen), Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland; Department of Internal Medicine (Neumann), Pontificia Universidad Catolica de Chile, Santiago, Chile; Institute of Health and Society (Vandvik), Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Medicine (Vandvik), Innlandet Hospital Trust, Division Gjövik, Norway; Clinical Epidemiology Unit (Akl), American University of Beirut, Beirut, Lebanon; Institute of Primary Health Care (da Costa), University of Bern, Bern, Switzerland; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari), Sunnybrook Health Sciences Centre, Toronto, Ont.; Interdepartmental Division of Critical Care (Adhikari), University of Toronto, Toronto, Ont.; School of Medicine and Centre for General Practice (Kosunen), University of Tampere and Pirkanmaa Hospital District, Tampere, Finland; School of Medicine and Department of Internal Medicine (Mustonen), University of Tampere and Tampere University Hospital, Tampere, Finland; Physiology and Experimental Medicine (Crawford), The Hospital for Sick Children Research Institute, Toronto, Ont.; Biostatistics Unit of the Centre for Evaluation of Medicines (Thabane), McMaster University, Hamilton, Ont.; Population Health Research Unit, Hamilton Health Sciences (Thabane), McMaster University, Hamilton, Ont.; Department of Medicine (Guyatt), McMaster University, Hamilton, Ont.
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Jukka Mustonen
Department of Anesthesia and Pain Medicine (Johnston, Crawford), The Hospital for Sick Children, University of Toronto, Toronto, Ont.; Institute of Health Policy, Management and Evaluation (Johnston), Dalla Lana School of Public Health, University of Toronto, Toronto, Ont.; Child Health Evaluative Sciences (Johnston), The Hospital for Sick Children Research Institute, Toronto, Ont.; Iberoamerican Cochrane Center (Alonso-Coello, Dalmau), Biomedical Research Institute Sant Pau, CIBER Epidemiologiay Salud Publica, Barcelona, Spain; Departments of Critical Care and Medicine (Friedrich), St. Michael’s Hospital, Toronto, Ont.; Department of Medicine and Interdepartmental Division of Critical Care (Friedrich), University of Toronto, Toronto, Ont.; Departments of Medicine and Biomedical and Health Informatics (Mustafa), University of Missouri–Kansas City, Kansas City, Mo.; Department of Clinical Epidemiology and Biostatistics (Mustafa, Tikkinen, Neumann, Akl, Thabane, Guyatt), McMaster University, Hamilton, Ont.; Departments of Urology and Public Health (Tikkinen), Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland; Department of Internal Medicine (Neumann), Pontificia Universidad Catolica de Chile, Santiago, Chile; Institute of Health and Society (Vandvik), Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Medicine (Vandvik), Innlandet Hospital Trust, Division Gjövik, Norway; Clinical Epidemiology Unit (Akl), American University of Beirut, Beirut, Lebanon; Institute of Primary Health Care (da Costa), University of Bern, Bern, Switzerland; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari), Sunnybrook Health Sciences Centre, Toronto, Ont.; Interdepartmental Division of Critical Care (Adhikari), University of Toronto, Toronto, Ont.; School of Medicine and Centre for General Practice (Kosunen), University of Tampere and Pirkanmaa Hospital District, Tampere, Finland; School of Medicine and Department of Internal Medicine (Mustonen), University of Tampere and Tampere University Hospital, Tampere, Finland; Physiology and Experimental Medicine (Crawford), The Hospital for Sick Children Research Institute, Toronto, Ont.; Biostatistics Unit of the Centre for Evaluation of Medicines (Thabane), McMaster University, Hamilton, Ont.; Population Health Research Unit, Hamilton Health Sciences (Thabane), McMaster University, Hamilton, Ont.; Department of Medicine (Guyatt), McMaster University, Hamilton, Ont.
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Mark W. Crawford
Department of Anesthesia and Pain Medicine (Johnston, Crawford), The Hospital for Sick Children, University of Toronto, Toronto, Ont.; Institute of Health Policy, Management and Evaluation (Johnston), Dalla Lana School of Public Health, University of Toronto, Toronto, Ont.; Child Health Evaluative Sciences (Johnston), The Hospital for Sick Children Research Institute, Toronto, Ont.; Iberoamerican Cochrane Center (Alonso-Coello, Dalmau), Biomedical Research Institute Sant Pau, CIBER Epidemiologiay Salud Publica, Barcelona, Spain; Departments of Critical Care and Medicine (Friedrich), St. Michael’s Hospital, Toronto, Ont.; Department of Medicine and Interdepartmental Division of Critical Care (Friedrich), University of Toronto, Toronto, Ont.; Departments of Medicine and Biomedical and Health Informatics (Mustafa), University of Missouri–Kansas City, Kansas City, Mo.; Department of Clinical Epidemiology and Biostatistics (Mustafa, Tikkinen, Neumann, Akl, Thabane, Guyatt), McMaster University, Hamilton, Ont.; Departments of Urology and Public Health (Tikkinen), Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland; Department of Internal Medicine (Neumann), Pontificia Universidad Catolica de Chile, Santiago, Chile; Institute of Health and Society (Vandvik), Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Medicine (Vandvik), Innlandet Hospital Trust, Division Gjövik, Norway; Clinical Epidemiology Unit (Akl), American University of Beirut, Beirut, Lebanon; Institute of Primary Health Care (da Costa), University of Bern, Bern, Switzerland; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari), Sunnybrook Health Sciences Centre, Toronto, Ont.; Interdepartmental Division of Critical Care (Adhikari), University of Toronto, Toronto, Ont.; School of Medicine and Centre for General Practice (Kosunen), University of Tampere and Pirkanmaa Hospital District, Tampere, Finland; School of Medicine and Department of Internal Medicine (Mustonen), University of Tampere and Tampere University Hospital, Tampere, Finland; Physiology and Experimental Medicine (Crawford), The Hospital for Sick Children Research Institute, Toronto, Ont.; Biostatistics Unit of the Centre for Evaluation of Medicines (Thabane), McMaster University, Hamilton, Ont.; Population Health Research Unit, Hamilton Health Sciences (Thabane), McMaster University, Hamilton, Ont.; Department of Medicine (Guyatt), McMaster University, Hamilton, Ont.
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Lehana Thabane
Department of Anesthesia and Pain Medicine (Johnston, Crawford), The Hospital for Sick Children, University of Toronto, Toronto, Ont.; Institute of Health Policy, Management and Evaluation (Johnston), Dalla Lana School of Public Health, University of Toronto, Toronto, Ont.; Child Health Evaluative Sciences (Johnston), The Hospital for Sick Children Research Institute, Toronto, Ont.; Iberoamerican Cochrane Center (Alonso-Coello, Dalmau), Biomedical Research Institute Sant Pau, CIBER Epidemiologiay Salud Publica, Barcelona, Spain; Departments of Critical Care and Medicine (Friedrich), St. Michael’s Hospital, Toronto, Ont.; Department of Medicine and Interdepartmental Division of Critical Care (Friedrich), University of Toronto, Toronto, Ont.; Departments of Medicine and Biomedical and Health Informatics (Mustafa), University of Missouri–Kansas City, Kansas City, Mo.; Department of Clinical Epidemiology and Biostatistics (Mustafa, Tikkinen, Neumann, Akl, Thabane, Guyatt), McMaster University, Hamilton, Ont.; Departments of Urology and Public Health (Tikkinen), Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland; Department of Internal Medicine (Neumann), Pontificia Universidad Catolica de Chile, Santiago, Chile; Institute of Health and Society (Vandvik), Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Medicine (Vandvik), Innlandet Hospital Trust, Division Gjövik, Norway; Clinical Epidemiology Unit (Akl), American University of Beirut, Beirut, Lebanon; Institute of Primary Health Care (da Costa), University of Bern, Bern, Switzerland; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari), Sunnybrook Health Sciences Centre, Toronto, Ont.; Interdepartmental Division of Critical Care (Adhikari), University of Toronto, Toronto, Ont.; School of Medicine and Centre for General Practice (Kosunen), University of Tampere and Pirkanmaa Hospital District, Tampere, Finland; School of Medicine and Department of Internal Medicine (Mustonen), University of Tampere and Tampere University Hospital, Tampere, Finland; Physiology and Experimental Medicine (Crawford), The Hospital for Sick Children Research Institute, Toronto, Ont.; Biostatistics Unit of the Centre for Evaluation of Medicines (Thabane), McMaster University, Hamilton, Ont.; Population Health Research Unit, Hamilton Health Sciences (Thabane), McMaster University, Hamilton, Ont.; Department of Medicine (Guyatt), McMaster University, Hamilton, Ont.
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Gordon H. Guyatt
Department of Anesthesia and Pain Medicine (Johnston, Crawford), The Hospital for Sick Children, University of Toronto, Toronto, Ont.; Institute of Health Policy, Management and Evaluation (Johnston), Dalla Lana School of Public Health, University of Toronto, Toronto, Ont.; Child Health Evaluative Sciences (Johnston), The Hospital for Sick Children Research Institute, Toronto, Ont.; Iberoamerican Cochrane Center (Alonso-Coello, Dalmau), Biomedical Research Institute Sant Pau, CIBER Epidemiologiay Salud Publica, Barcelona, Spain; Departments of Critical Care and Medicine (Friedrich), St. Michael’s Hospital, Toronto, Ont.; Department of Medicine and Interdepartmental Division of Critical Care (Friedrich), University of Toronto, Toronto, Ont.; Departments of Medicine and Biomedical and Health Informatics (Mustafa), University of Missouri–Kansas City, Kansas City, Mo.; Department of Clinical Epidemiology and Biostatistics (Mustafa, Tikkinen, Neumann, Akl, Thabane, Guyatt), McMaster University, Hamilton, Ont.; Departments of Urology and Public Health (Tikkinen), Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland; Department of Internal Medicine (Neumann), Pontificia Universidad Catolica de Chile, Santiago, Chile; Institute of Health and Society (Vandvik), Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Medicine (Vandvik), Innlandet Hospital Trust, Division Gjövik, Norway; Clinical Epidemiology Unit (Akl), American University of Beirut, Beirut, Lebanon; Institute of Primary Health Care (da Costa), University of Bern, Bern, Switzerland; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari), Sunnybrook Health Sciences Centre, Toronto, Ont.; Interdepartmental Division of Critical Care (Adhikari), University of Toronto, Toronto, Ont.; School of Medicine and Centre for General Practice (Kosunen), University of Tampere and Pirkanmaa Hospital District, Tampere, Finland; School of Medicine and Department of Internal Medicine (Mustonen), University of Tampere and Tampere University Hospital, Tampere, Finland; Physiology and Experimental Medicine (Crawford), The Hospital for Sick Children Research Institute, Toronto, Ont.; Biostatistics Unit of the Centre for Evaluation of Medicines (Thabane), McMaster University, Hamilton, Ont.; Population Health Research Unit, Hamilton Health Sciences (Thabane), McMaster University, Hamilton, Ont.; Department of Medicine (Guyatt), McMaster University, Hamilton, Ont.
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Article Information

vol. 188 no. 1 25-32
DOI 
https://doi.org/10.1503/cmaj.150430
PubMed 
26504102
History 
  • Accepted September 9, 2015
  • Published online January 4, 2016.

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  • Latest version (October 26, 2015 - 08:31).
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© 2016 Canadian Medical Association or its licensors

Author Information

  1. Bradley C. Johnston, PhD⇑,
  2. Pablo Alonso-Coello, MD PhD,
  3. Jan O. Friedrich, MD,
  4. Reem A. Mustafa, MD PhD,
  5. Kari A.O. Tikkinen, MD PhD,
  6. Ignacio Neumann, MD,
  7. Per O. Vandvik, MD PhD,
  8. Elie A. Akl, MD PhD,
  9. Bruno R. da Costa, PhD,
  10. Neill K. Adhikari, MD,
  11. Gemma Mas Dalmau, MD,
  12. Elise Kosunen, MD PhD,
  13. Jukka Mustonen, MD PhD,
  14. Mark W. Crawford, MD,
  15. Lehana Thabane, PhD,
  16. Gordon H. Guyatt, MD
  1. Department of Anesthesia and Pain Medicine (Johnston, Crawford), The Hospital for Sick Children, University of Toronto, Toronto, Ont.; Institute of Health Policy, Management and Evaluation (Johnston), Dalla Lana School of Public Health, University of Toronto, Toronto, Ont.; Child Health Evaluative Sciences (Johnston), The Hospital for Sick Children Research Institute, Toronto, Ont.; Iberoamerican Cochrane Center (Alonso-Coello, Dalmau), Biomedical Research Institute Sant Pau, CIBER Epidemiologiay Salud Publica, Barcelona, Spain; Departments of Critical Care and Medicine (Friedrich), St. Michael’s Hospital, Toronto, Ont.; Department of Medicine and Interdepartmental Division of Critical Care (Friedrich), University of Toronto, Toronto, Ont.; Departments of Medicine and Biomedical and Health Informatics (Mustafa), University of Missouri–Kansas City, Kansas City, Mo.; Department of Clinical Epidemiology and Biostatistics (Mustafa, Tikkinen, Neumann, Akl, Thabane, Guyatt), McMaster University, Hamilton, Ont.; Departments of Urology and Public Health (Tikkinen), Helsinki University Central Hospital and University of Helsinki, Helsinki, Finland; Department of Internal Medicine (Neumann), Pontificia Universidad Catolica de Chile, Santiago, Chile; Institute of Health and Society (Vandvik), Faculty of Medicine, University of Oslo, Oslo, Norway; Department of Medicine (Vandvik), Innlandet Hospital Trust, Division Gjövik, Norway; Clinical Epidemiology Unit (Akl), American University of Beirut, Beirut, Lebanon; Institute of Primary Health Care (da Costa), University of Bern, Bern, Switzerland; Department of Critical Care Medicine and Sunnybrook Research Institute (Adhikari), Sunnybrook Health Sciences Centre, Toronto, Ont.; Interdepartmental Division of Critical Care (Adhikari), University of Toronto, Toronto, Ont.; School of Medicine and Centre for General Practice (Kosunen), University of Tampere and Pirkanmaa Hospital District, Tampere, Finland; School of Medicine and Department of Internal Medicine (Mustonen), University of Tampere and Tampere University Hospital, Tampere, Finland; Physiology and Experimental Medicine (Crawford), The Hospital for Sick Children Research Institute, Toronto, Ont.; Biostatistics Unit of the Centre for Evaluation of Medicines (Thabane), McMaster University, Hamilton, Ont.; Population Health Research Unit, Hamilton Health Sciences (Thabane), McMaster University, Hamilton, Ont.; Department of Medicine (Guyatt), McMaster University, Hamilton, Ont.
  1. Correspondence to: Bradley Johnston, bradley.johnston{at}sickkids.ca
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Do clinicians understand the size of treatment effects? A randomized survey across 8 countries
Bradley C. Johnston, Pablo Alonso-Coello, Jan O. Friedrich, Reem A. Mustafa, Kari A.O. Tikkinen, Ignacio Neumann, Per O. Vandvik, Elie A. Akl, Bruno R. da Costa, Neill K. Adhikari, Gemma Mas Dalmau, Elise Kosunen, Jukka Mustonen, Mark W. Crawford, Lehana Thabane, Gordon H. Guyatt
CMAJ Jan 2016, 188 (1) 25-32; DOI: 10.1503/cmaj.150430

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Do clinicians understand the size of treatment effects? A randomized survey across 8 countries
Bradley C. Johnston, Pablo Alonso-Coello, Jan O. Friedrich, Reem A. Mustafa, Kari A.O. Tikkinen, Ignacio Neumann, Per O. Vandvik, Elie A. Akl, Bruno R. da Costa, Neill K. Adhikari, Gemma Mas Dalmau, Elise Kosunen, Jukka Mustonen, Mark W. Crawford, Lehana Thabane, Gordon H. Guyatt
CMAJ Jan 2016, 188 (1) 25-32; DOI: 10.1503/cmaj.150430
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