Skip to main content

Main menu

  • Home
  • Content
    • Current issue
    • Past issues
    • Early releases
    • Collections
    • Sections
    • Blog
    • Infographics & illustrations
    • Podcasts
    • COVID-19 Articles
  • Authors
    • Overview for authors
    • Submission guidelines
    • Submit a manuscript
    • Forms
    • Editorial process
    • Editorial policies
    • Peer review process
    • Publication fees
    • Reprint requests
    • Open access
  • CMA Members
    • Overview for members
    • Earn CPD Credits
    • Print copies of CMAJ
  • Subscribers
    • General information
    • View prices
  • Alerts
    • Email alerts
    • RSS
  • JAMC
    • À propos
    • Numéro en cours
    • Archives
    • Sections
    • Abonnement
    • Alertes
    • Trousse média 2022
  • CMAJ JOURNALS
    • CMAJ Open
    • CJS
    • JAMC
    • JPN

User menu

Search

  • Advanced search
CMAJ
  • CMAJ JOURNALS
    • CMAJ Open
    • CJS
    • JAMC
    • JPN
CMAJ

Advanced Search

  • Home
  • Content
    • Current issue
    • Past issues
    • Early releases
    • Collections
    • Sections
    • Blog
    • Infographics & illustrations
    • Podcasts
    • COVID-19 Articles
  • Authors
    • Overview for authors
    • Submission guidelines
    • Submit a manuscript
    • Forms
    • Editorial process
    • Editorial policies
    • Peer review process
    • Publication fees
    • Reprint requests
    • Open access
  • CMA Members
    • Overview for members
    • Earn CPD Credits
    • Print copies of CMAJ
  • Subscribers
    • General information
    • View prices
  • Alerts
    • Email alerts
    • RSS
  • JAMC
    • À propos
    • Numéro en cours
    • Archives
    • Sections
    • Abonnement
    • Alertes
    • Trousse média 2022
  • Visit CMAJ on Facebook
  • Follow CMAJ on Twitter
  • Follow CMAJ on Pinterest
  • Follow CMAJ on Youtube
  • Follow CMAJ on Instagram
Review

Grapefruit–medication interactions: Forbidden fruit or avoidable consequences?

David G. Bailey, George Dresser and J. Malcolm O. Arnold
CMAJ March 05, 2013 185 (4) 309-316; DOI: https://doi.org/10.1503/cmaj.120951
David G. Bailey
From the Lawson Health Research Institute (Bailey), London, Ont.; the Department of Medicine (Arnold, Dresser) and the Divisions of Cardiology (Arnold) and Clinical Pharmacology (Dresser), Western University, London, Ont.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • For correspondence: david.bailey@lhsc.on.ca
George Dresser
From the Lawson Health Research Institute (Bailey), London, Ont.; the Department of Medicine (Arnold, Dresser) and the Divisions of Cardiology (Arnold) and Clinical Pharmacology (Dresser), Western University, London, Ont.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
J. Malcolm O. Arnold
From the Lawson Health Research Institute (Bailey), London, Ont.; the Department of Medicine (Arnold, Dresser) and the Divisions of Cardiology (Arnold) and Clinical Pharmacology (Dresser), Western University, London, Ont.
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Tables
  • Related Content
  • Responses
  • Metrics
  • PDF
Loading

Article Information

vol. 185 no. 4 309-316
DOI 
https://doi.org/10.1503/cmaj.120951
PubMed 
23184849
History 
  • Published online March 4, 2013.

Article Versions

  • Latest version (November 26, 2012 - 08:19).
  • You are viewing the most recent version of this article.
Copyright & Usage 
© 2013 Canadian Medical Association or its licensors

Author Information

  1. David G. Bailey, BScPhm PhD⇑,
  2. George Dresser, MD PhD,
  3. J. Malcolm O. Arnold, MB BCh MD
  1. From the Lawson Health Research Institute (Bailey), London, Ont.; the Department of Medicine (Arnold, Dresser) and the Divisions of Cardiology (Arnold) and Clinical Pharmacology (Dresser), Western University, London, Ont.
  1. Correspondence to:
    David G. Bailey, david.bailey{at}lhsc.on.ca

Statistics from Altmetric.com

Usage statistics: November 2012 to August 2022

AbstractFullPdf
Nov 2012001074
Dec 201200450
Jan 201302357
Feb 20130561
Mar 20130269217
Apr 201307760
May 201303338
Jun 2013925840
Jul 2013253520
Aug 2013342324
Sep 2013442547
Oct 2013745435
Nov 2013443884
Dec 20131749475
Jan 20147926786
Feb 20142120457
Mar 201411524622
Apr 201484591597
May 20147357563
Jun 201416773651
Jul 201443360419
Aug 201416327688
Sep 201410381626
Oct 201414453455
Nov 20146460396
Dec 20149461353
Jan 201531199663
Feb 201511583478
Mar 201510488393
Apr 20155584468
May 201511442344
Jun 20156412477
Jul 201523392383
Aug 20156594318
Sep 20157584373
Oct 20156467372
Nov 201510429417
Dec 201512488383
Jan 201618620690
Feb 20164513452
Mar 20165557461
Apr 201611570391
May 20169406316
Jun 201616413324
Jul 201616316314
Aug 20169377300
Sep 20166597327
Oct 201617782312
Nov 20168606404
Dec 20169625450
Jan 201711592639
Feb 20177732664
Mar 2017101000561
Apr 20177947415
May 201712571358
Jun 20177514331
Jul 201713499358
Aug 20179490323
Sep 20174416294
Oct 201714665570
Nov 20175668283
Dec 20170409123
Jan 20180555176
Feb 20180330208
Mar 20180335211
Apr 20180280173
May 2018031381
Jun 2018027471
Jul 2018027279
Aug 2018042295
Sep 20180326109
Oct 20180353109
Nov 2018083493
Dec 2018066099
Jan 20190873398
Feb 2019075082
Mar 20190671119
Apr 20190629178
May 201901117120
Jun 2019060791
Jul 2019053987
Aug 2019068596
Sep 20190569129
Oct 20190697140
Nov 201901159203
Dec 201901082132
Jan 202001652798
Feb 202002632163
Mar 202002193159
Apr 202002145249
May 202002482309
Jun 202002103186
Jul 202002254114
Aug 202002471190
Sep 202003407184
Oct 202004382233
Nov 202003239470
Dec 202003345225
Jan 202102751225
Feb 202102065232
Mar 202102177194
Apr 202102066234
May 202102031288
Jun 202101710188
Jul 202101657142
Aug 202101472138
Sep 202101795243
Oct 202101675215
Nov 202101932230
Dec 202101531379
Jan 202202228191
Feb 202201787186
Mar 202201661328
Apr 202201315248
May 202201108178
Jun 202201347169
Jul 202201489141
Aug 2022066566

Cited By...

  • 124 Citations
  • Google Scholar
PreviousNext
Back to top

In this issue

Canadian Medical Association Journal: 185 (4)
CMAJ
Vol. 185, Issue 4
5 Mar 2013
  • Table of Contents
  • Index by author

Article tools

Respond to this article
Print
Download PDF
Article Alerts
To sign up for email alerts or to access your current email alerts, enter your email address below:
Email Article

Thank you for your interest in spreading the word on CMAJ.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Grapefruit–medication interactions: Forbidden fruit or avoidable consequences?
(Your Name) has sent you a message from CMAJ
(Your Name) thought you would like to see the CMAJ web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Grapefruit–medication interactions: Forbidden fruit or avoidable consequences?
David G. Bailey, George Dresser, J. Malcolm O. Arnold
CMAJ Mar 2013, 185 (4) 309-316; DOI: 10.1503/cmaj.120951

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
‍ Request Permissions
Share
Grapefruit–medication interactions: Forbidden fruit or avoidable consequences?
David G. Bailey, George Dresser, J. Malcolm O. Arnold
CMAJ Mar 2013, 185 (4) 309-316; DOI: 10.1503/cmaj.120951
Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like

Jump to section

  • Article
    • What are the key scientific concepts of grapefruit–drug interactions?
    • What determines which drugs are affected?
    • What determines the clinical significance of the interaction?
    • Who is at higher risk of grapefruit–drug interactions?
    • What are examples of important grapefruit–drug interactions?
    • Gaps in knowledge
    • Conclusion
    • Footnotes
    • References
  • Figures & Tables
  • Related Content
  • Responses
  • Metrics
  • PDF

Related Articles

  • Highlights
  • PubMed
  • Google Scholar

Cited By...

  • Parallel evolution of UbiA superfamily proteins into aromatic O-prenyltransferases in plants
  • Natural Products as Modulators of CES1 Activity
  • Parallel evolution of UbiA superfamily proteins into aromatic O-prenyltransferases in plants
  • Regional Proteomic Quantification of Clinically Relevant Non-Cytochrome P450 Enzymes along the Human Small Intestine
  • Severity of coeliac disease and clinical management study when using a CYP3A4 metabolised medication: a phase I pharmacokinetic study
  • Milk Thistle Constituents Inhibit Raloxifene Intestinal Glucuronidation: A Potential Clinically Relevant Natural Product-Drug Interaction
  • Citrus Consumption and Risk of Cutaneous Malignant Melanoma
  • Assessment of a Candidate Marker Constituent Predictive of a Dietary Substance-Drug Interaction: Case Study with Grapefruit Juice and CYP3A4 Drug Substrates
  • Identification of Diet-Derived Constituents as Potent Inhibitors of Intestinal Glucuronidation
  • Grapefruit juice and clopidogrel
  • Grapefruit juice and clopidogrel
  • Comparing two types of macrolide antibiotics for the purpose of assessing population-based drug interactions
  • Grapefruit-medication interactions
  • Grapefruit-medication interactions
  • Google Scholar

More in this TOC Section

  • Diagnosis and management of postural orthostatic tachycardia syndrome
  • A practical approach to prescribing antiplatelet therapy in patients with acute coronary syndromes
  • Prevention and management of hyperkalemia in patients treated with renin–angiotensin–aldosterone system inhibitors
Show more Review

Similar Articles

Collections

  • Topics
    • Drugs: adverse reactions

 

View Latest Classified Ads

Content

  • Current issue
  • Past issues
  • Collections
  • Sections
  • Blog
  • Podcasts
  • Alerts
  • RSS
  • Early releases

Information for

  • Advertisers
  • Authors
  • Reviewers
  • CMA Members
  • CPD credits
  • Media
  • Reprint requests
  • Subscribers

About

  • General Information
  • Journal staff
  • Editorial Board
  • Advisory Panels
  • Governance Council
  • Journal Oversight
  • Careers
  • Contact
  • Copyright and Permissions
  • Accessibiity
  • CMA Civility Standards
CMAJ Group

Copyright 2022, CMA Impact Inc. or its licensors. All rights reserved. ISSN 1488-2329 (e) 0820-3946 (p)

All editorial matter in CMAJ represents the opinions of the authors and not necessarily those of the Canadian Medical Association or its subsidiaries.

To receive any of these resources in an accessible format, please contact us at CMAJ Group, 500-1410 Blair Towers Place, Ottawa ON, K1J 9B9; p: 1-888-855-2555; e: cmajgroup@cmaj.ca

Powered by HighWire