Course | Self-limiting | Persistent |
Severity | Mild | Mild to severe |
Persistent fevers | Rare | May be present |
Anemia | Secondary to bone marrow suppression | Secondary to autoimmune hemolysis |
Reticulocyte count | Low in presence of bone marrow suppression | Normal to high in presence of evidence of hemolysis |
Splenomegaly | Rare | May be present |
Discoid lesions, alopecia | Absent | May be present |
Oral ulcers | Rare | May be present |
Raynaud phenomenon | Absent | May be present |
Neurologic (seizures, psychosis, chorea) and ocular symptoms | Rare | May be present |
Gastrointestinal involvement (peritonitis, pancreatitis, obstruction/pseudo-obstruction) | Rare | May be present |
Cardiac involvement | Rare | May be present |
Renal involvement | Rare | May be present |