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Practice

Acetaminophen overdose in children

Jacqueline D. Ogilvie, Michael J. Rieder and Rodrick Lim
CMAJ September 18, 2012 184 (13) 1492-1496; DOI: https://doi.org/10.1503/cmaj.111338
Jacqueline D. Ogilvie
From the Department of Pediatrics (Ogilvie, Rieder, Lim) and the Division of Clinical Pharmacology (Rieder), Department of Medicine, Children’s Hospital, London Health Sciences Centre, London, Ont.
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Michael J. Rieder
From the Department of Pediatrics (Ogilvie, Rieder, Lim) and the Division of Clinical Pharmacology (Rieder), Department of Medicine, Children’s Hospital, London Health Sciences Centre, London, Ont.
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Rodrick Lim
From the Department of Pediatrics (Ogilvie, Rieder, Lim) and the Division of Clinical Pharmacology (Rieder), Department of Medicine, Children’s Hospital, London Health Sciences Centre, London, Ont.
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  • For correspondence: Rod.Lim@lhsc.on.ca
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    Figure 1:

    Acetaminophen metabolism. N-acetyl-p-aminophenol (APAP) is the active component of acetaminophen and is metabolized by 3 pathways: glucuronidation, sulfation and glutathione conjugation. Glucuronidation and sulfation produce nontoxic metabolites for excretion. N-acetyl-p-benzoquinoneimine (NAPQI) is a toxic intermediate produced by cytochrome P450 2E1 (CYP2E1; the main metabolizing agent) and cytochrome P450 3A4 (CYP3A4) metabolism. NAPQI is then conjugated by glutathione to form a nontoxic metabolite for excretion.

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Canadian Medical Association Journal: 184 (13)
CMAJ
Vol. 184, Issue 13
18 Sep 2012
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Acetaminophen overdose in children
Jacqueline D. Ogilvie, Michael J. Rieder, Rodrick Lim
CMAJ Sep 2012, 184 (13) 1492-1496; DOI: 10.1503/cmaj.111338

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Acetaminophen overdose in children
Jacqueline D. Ogilvie, Michael J. Rieder, Rodrick Lim
CMAJ Sep 2012, 184 (13) 1492-1496; DOI: 10.1503/cmaj.111338
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