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Research

Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial

Jody Corey-Bloom, Tanya Wolfson, Anthony Gamst, Shelia Jin, Thomas D. Marcotte, Heather Bentley and Ben Gouaux
CMAJ July 10, 2012 184 (10) 1143-1150; DOI: https://doi.org/10.1503/cmaj.110837
Jody Corey-Bloom
From the Departments of Neurosciences (Corey-Bloom), Biostatistics (Wolfson, Gamst, Jin) and Psychiatry (Marcotte, Bentley); and the Center for Medicinal Cannabis Research (Marcotte, Bentley, Gouaux), University of California, San Diego, La Jolla, Calif.
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  • For correspondence: jcoreybloom@ucsd.edu
Tanya Wolfson
From the Departments of Neurosciences (Corey-Bloom), Biostatistics (Wolfson, Gamst, Jin) and Psychiatry (Marcotte, Bentley); and the Center for Medicinal Cannabis Research (Marcotte, Bentley, Gouaux), University of California, San Diego, La Jolla, Calif.
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Anthony Gamst
From the Departments of Neurosciences (Corey-Bloom), Biostatistics (Wolfson, Gamst, Jin) and Psychiatry (Marcotte, Bentley); and the Center for Medicinal Cannabis Research (Marcotte, Bentley, Gouaux), University of California, San Diego, La Jolla, Calif.
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Shelia Jin
From the Departments of Neurosciences (Corey-Bloom), Biostatistics (Wolfson, Gamst, Jin) and Psychiatry (Marcotte, Bentley); and the Center for Medicinal Cannabis Research (Marcotte, Bentley, Gouaux), University of California, San Diego, La Jolla, Calif.
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Thomas D. Marcotte
From the Departments of Neurosciences (Corey-Bloom), Biostatistics (Wolfson, Gamst, Jin) and Psychiatry (Marcotte, Bentley); and the Center for Medicinal Cannabis Research (Marcotte, Bentley, Gouaux), University of California, San Diego, La Jolla, Calif.
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Heather Bentley
From the Departments of Neurosciences (Corey-Bloom), Biostatistics (Wolfson, Gamst, Jin) and Psychiatry (Marcotte, Bentley); and the Center for Medicinal Cannabis Research (Marcotte, Bentley, Gouaux), University of California, San Diego, La Jolla, Calif.
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Ben Gouaux
From the Departments of Neurosciences (Corey-Bloom), Biostatistics (Wolfson, Gamst, Jin) and Psychiatry (Marcotte, Bentley); and the Center for Medicinal Cannabis Research (Marcotte, Bentley, Gouaux), University of California, San Diego, La Jolla, Calif.
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  • Re:Smoked cannabis for spasticity in MS
    Giovanni Alessandrini
    Posted on: 28 May 2012
  • Re:Smoked cannabis for spasticity in MS
    Jason Sholtanuk
    Posted on: 22 May 2012
  • Smoked cannabis for spasticity in MS
    Richard Cunningham
    Posted on: 17 May 2012
  • Posted on: (28 May 2012)
    Page navigation anchor for Re:Smoked cannabis for spasticity in MS
    Re:Smoked cannabis for spasticity in MS
    • Giovanni Alessandrini, patient

    As one comment (Richard Cunningham) mentions the harm caused by smoked cannabis, I would be interested in having bibliographical references on this issue.

    Another question, more strictly related to the article is: is there a difference in cognitive impairment associated to smoked cannabis between healthy people and MS patients?

    Conflict of Interest:

    None declared

    ...
    Show More

    As one comment (Richard Cunningham) mentions the harm caused by smoked cannabis, I would be interested in having bibliographical references on this issue.

    Another question, more strictly related to the article is: is there a difference in cognitive impairment associated to smoked cannabis between healthy people and MS patients?

    Conflict of Interest:

    None declared

    Show Less
    Competing Interests: None declared.
  • Posted on: (22 May 2012)
    Page navigation anchor for Re:Smoked cannabis for spasticity in MS
    Re:Smoked cannabis for spasticity in MS
    • Jason Sholtanuk, Director of Patient Services

    In reference to all uninformed negative comments on the use of medicinal cannabis for MS, cancer, HIV/aids, arthritis, etc., Please refer to the Cannabis Trade Association's (CTA) Facebook Page where one can review all current research about medicinal Cannabis. Whilst it is common knowledge that inhaling any form of smoke is potentially hazardous there is ample research about cannabis and its newly discovered compounds. F...

    Show More

    In reference to all uninformed negative comments on the use of medicinal cannabis for MS, cancer, HIV/aids, arthritis, etc., Please refer to the Cannabis Trade Association's (CTA) Facebook Page where one can review all current research about medicinal Cannabis. Whilst it is common knowledge that inhaling any form of smoke is potentially hazardous there is ample research about cannabis and its newly discovered compounds. For example, when eaten in its raw form the psycho active ingredient commonly referred to as THC, does not become active until it is heated (i.e., smoked). In other words, when eaten raw, like a vegetable, one does not become "high." Government funded research in Canada and throughout the world on the other lesser known compounds within the cannabis plant called cannabinoids has shown to have a multitude of positive effects on myriad diseases including MS and cancer cells. As a nonprofit association working with Health Canada and physicians for a safe and regulated cannabis industry we aim to help educate people about the facts of this simple but complex plant called cannabis. Again, we welcome all to visit our Facebook page for more information about our organization and daily updated information about medicinal cannabis.

    http://www.facebook.com/pages/CTA-Cannabis-Trade-Association- /280714238666155

    When in doubt, Google it: cannabinoids

    Conflict of Interest:

    None declared

    Show Less
    Competing Interests: None declared.
  • Posted on: (17 May 2012)
    Page navigation anchor for Smoked cannabis for spasticity in MS
    Smoked cannabis for spasticity in MS
    • Richard Cunningham, Family physician

    Less cognitive impact! It is amazing to me that the medical profession would consider the use of inhaled cannabis for anything. Inhaling cannabis is more harmful to lung tissue than inhaled tobacco, having at least 300 chemicals. As was alluded to as a side effect, it makes people stupid. Do we want to make these poor patients stupid and spastic.Inhaled cannabis has no place in medicine.

    Conflict of Interest:...

    Show More

    Less cognitive impact! It is amazing to me that the medical profession would consider the use of inhaled cannabis for anything. Inhaling cannabis is more harmful to lung tissue than inhaled tobacco, having at least 300 chemicals. As was alluded to as a side effect, it makes people stupid. Do we want to make these poor patients stupid and spastic.Inhaled cannabis has no place in medicine.

    Conflict of Interest:

    None declared

    Show Less
    Competing Interests: None declared.
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Canadian Medical Association Journal: 184 (10)
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Vol. 184, Issue 10
10 Jul 2012
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Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial
Jody Corey-Bloom, Tanya Wolfson, Anthony Gamst, Shelia Jin, Thomas D. Marcotte, Heather Bentley, Ben Gouaux
CMAJ Jul 2012, 184 (10) 1143-1150; DOI: 10.1503/cmaj.110837

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Smoked cannabis for spasticity in multiple sclerosis: a randomized, placebo-controlled trial
Jody Corey-Bloom, Tanya Wolfson, Anthony Gamst, Shelia Jin, Thomas D. Marcotte, Heather Bentley, Ben Gouaux
CMAJ Jul 2012, 184 (10) 1143-1150; DOI: 10.1503/cmaj.110837
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  • Medical cannabis or cannabinoids for chronic non-cancer and cancer related pain: a systematic review and meta-analysis of randomised clinical trials
  • Working With Clients Who Opt to Use Marijuana as an Alternative Treatment for Chronic Health Conditions
  • Cannabis for pain in orthopedics: a systematic review focusing on study methodology
  • The Misclassification of Medical Marijuana
  • Efficacy and adverse effects of medical marijuana for chronic noncancer pain: Systematic review of randomized controlled trials
  • Prescribing smoked cannabis for chronic noncancer pain: Preliminary recommendations
  • Prescrire du cannabis fume pour la douleur chronique non cancereuse: Recommandations preliminaires
  • Systematic review: Efficacy and safety of medical marijuana in selected neurologic disorders: Report of the Guideline Development Subcommittee of the American Academy of Neurology
  • Should doctors prescribe cannabinoids?
  • Summary of evidence-based guideline: Complementary and alternative medicine in multiple sclerosis: Report of the Guideline Development Subcommittee of the American Academy of Neurology
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