Article Figures & Tables
Figures
- Figure 1:
Selection of patients for inclusion in the study cohort. ECG = electrocardiogram, LBBB = left bundle branch block, MI = myocardial infarction, PCI = percutaneous coronary intervention, STEMI = ST-segment elevation myocardial infarction.
- Figure 2:
Kaplan–Meier survival analysis of all-cause mortality within one year of randomization, by the presence of Q waves. p logrank < 0.001.
- Figure 3:
Kaplan–Meier survival analysis of all-cause mortality within one year, by time from the onset of symptoms to percutaneous coronary intervention (PCI). p logrank = 0.03.
- Figure 4:
Associations among baseline Q waves, time from symptom onset and mortality. (A) Association between all-cause mortality within one year and baseline Q waves and time from symptom onset to percutaneous coronary intervention (PCI). *Adjusted for age, systolic blood pressure, heart rate, Killip class, myocardial infarction location, Q waves and time from symptom onset. (B) Association between vascular mortality within one year and baseline Q waves and time from the onset of symptoms to PCI. †Adjusted for age, systolic blood pressure, heart rate, Killip class, myocardial infarction location, presence of Q waves and time from symptom onset.
Tables
- Table 1:
Characteristics of the included patients, by time from the onset of symptoms to percutaneous coronary intervention and the presence of baseline Q waves
Characteristic; median (25th, 75th percentile)* All patients
n = 4341Time from the onset of symptoms to PCI ≤ 3 h
n = 1052> 3 to ≤ 6 h
n = 1675> 6 hr
n = 1614No Q waves n = 2338 Q waves n = 2003 p value No Q waves n = 631 Q waves n = 421 p value No Q waves n = 942 Q waves n = 733 p value No Q waves n = 765 Q waves n = 849 p value Age, yr 57 (51, 66) 59 (52, 68) < 0.001 56 (50, 64) 58 (52, 66) 0.03 57 (51, 65) 59 (53, 68) 0.001 59 (52, 68) 60 (52, 69) 0.09 Female, % 25.7 20.8 < 0.001 19.7 17.6 0.4 25.5 19.9 0.007 30.9 23.1 < 0.001 Diabetes mellitus, % 17.2 18.3 0.3 16.6 13.8 0.2 14.9 19.4 0.01 20.4 19.6 0.7 Hypertension, % 55.9 56.7 0.6 48.7 52.3 0.2 55.6 57.3 0.49 62.4 58.4 0.1 Heart rate, beats per min 74 (65, 84) 78 (68, 90) < 0.001 74 (65, 84) 77 (66, 88) 0.002 74 (65, 83) 79 (70, 90) < 0.001 75 (65, 84) 78 (68, 90) < 0.001 Systolic blood pressure, mm Hg 130 (120, 150) 133 (120, 150) 0.7 130 (120, 147) 135 (120, 150) 0.1 135 (120, 150) 135 (120, 150) 0.8 132 (120, 150) 130 (120, 150) 0.6 Killip class > 1, % 5.0 8.3 < 0.001 4.1 7.1 0.03 4.1 6.7 0.02 6.7 10.3 0.01 Creatinine clearance, mL/min 89.9 (73.1, 105.9) 85.8 (68.2, 105) 0.001 90.1 (74.5, 104.6) 87.7 (68.2, 104.2) 0.06 90.1 (74.2, 107) 84.7 (68.3, 104.6) 0.001 89.3 (70.2, 105.8) 85.8 (68.2, 105.6) 0.2 Time from symptom onset to baseline ECG, hr 2.3 (1.2, 4.2) 3.0 (1.6, 6.0) < 0.001 1.1 (0.7, 1.6) 1.3 (0.8, 1.7) < 0.001 2.5 (1.7, 3.3) 2.8 (1.9, 3.6) < 0.001 5.6 (3.1, 8.4) 7 (4.5, 11.1) < 0.001 Time from symptom onset to PCI, hr 4.3 (2.9, 7.3) 5.3 (3.3, 9.5) < 0.001 2.3 (1.9, 2.7) 2.4 (2.0, 2.7) 0.1 4.2 (3.5, 4.9) 4.3 (3.6, 5.1) 0.003 9.8 (7.4. 15.3) 10.7 (7.8, 17.1) 0.004 Note: ECG = electrocardiogram, PCI = percutaneous coronary intervention.
↵* Unless otherwise stated.
- Table 2:
Myocardial infarction location, electrocardiography metrics and cardiac biomarkers for the study population, by time from the onset of symptoms to percutaneous coronary intervention and the presence of baseline Q waves
Characteristic; median (25th, 75th percentile)* All patients
n = 4341Time from the onset of symptoms to PCI ≤ 3 h
n = 1052> 3 to ≤ 6 h
n = 1675> 6 h
n = 1614No Q waves n = 2338 Q waves n = 2003 p value No Q waves n = 631 Q waves n = 421 p value No Q waves n = 942 Q waves n = 733 p value No Q waves n = 765 Q waves n = 849 p value Inferior MI, % of patients 61.1 34.4 < 0.001 65.9 33.0 < 0.001 63.4 34.9 < 0.001 53.7 34.6 < 0.001 Baseline sum ST-segment elevation (∑ST-elevation), mm 5 (2.5, 9) 7.5 (4, 12.5) < 0.001 6.5 (4, 11) 9.5 (5.5, 16) < 0.001 5.5 (3, 9.5) 8.5 (5, 14) < 0.001 3.5 (2, 6.5) 5.5 (3, 10) < 0.001 Baseline sum ST-segment deviation (∑ST-deviation), mm 9.5 (5.5, 15.5) 11 (6.5, 17.5) < 0.001 11.5 (7, 17.5) 13.5 (8.5, 21) < 0.001 10.5 (6.5, 17) 13 (8, 20) < 0.001 7 (4, 11.5) 9 (5, 13.5) < 0.001 Sum ST-segment elevation resolution (∑ST-elevation) ≥ 50%, % 79.0 66.5 < 0.001 86.8 76.9 < 0.001 82.4 72.5 < 0.001 67.5 56.3 < 0.001 Sum ST-segment deviation resolution (∑ST-deviation) ≥ 50%, % 78.7 67.1 < 0.001 84.5 79.2 0.050 85.1 73.8 < 0.001 65.3 55.4 < 0.001 Cardiac biomarkers Central troponin I ≥ 0.08 ng/mL at study entry, % 84.5 91.8 < 0.001 70.2 80.1 0.001 86.1 93.6 < 0.001 94.4 96.0 < 0.05 Peak local creatine kinase-MB, ratio of the ULN n = 1568
5.1 (1.8, 12.7)n = 1379
7.6 (2.6, 19.3)< 0.001 n = 421
4.4 (1.6, 12.1)n = 270
9.2 (2.6, 21.3)< 0.001 n = 659
6 (2.1, 13.8)n = 520
8.2 (2.7, 20.7)< 0.001 n = 488
3.9 (1.7, 10.2)n = 589
6.7 (2.5, 16.7)< 0.001 Peak local troponin I, ratio of the ULN n = 1280
49.7 (5.3, 199.9)n = 1024
100 (15.7, 374.5)< 0.001 n = 375
56.3 (4.1, 228)n = 242
96.9 (12.2, 320.0)0.008 n = 492
57 (4.9, 215.1)n = 369
103.4 (12.1, 434.8)< 0.001 n = 413
42.4 (8, 166.7)n = 413
97.4 (28.8, 362.7)< 0.001 Peak local troponin T, ratio of the ULN n = 740
19.0 (2.9, 67.8)n = 620
37.9 (8.7, 115.1)< 0.001 n = 187
22.3 (4.4, 82.7)n = 129
39 (7.8, 116.5)0.068 n = 309
20 (2.7, 66.7)n = 222
41.7 (9, 103.5)< 0.001 n = 244
12.8 (2.5, 60.5)n = 269
31.7 (8.6, 116)< 0.001 Note: MI = myocardial infarction, PCI = percutaneous coronary intervention, ULN = upper limit of normal.
↵* Sum ST-deviation is the elevation plus depression.
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