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Framework urges physicians to proceed with caution on palliative sedation

Lauren Vogel
CMAJ February 08, 2011 183 (2) 174-175; DOI: https://doi.org/10.1503/cmaj.109-3766
Lauren Vogel
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Easily the most controversial tool in the palliative care arsenal, the practice of sedating patients near death to relieve intolerable and refractory suffering may also be the most widely misunderstood.

Debate over the therapy’s potential for misuse, confounded by a lack of clear or consistent guidance on its ethical and medically appropriate use, has misled the public and even some health professionals to view it as a covert form of euthanasia, says Dr. Larry Librach, director of the Temmy Latner Centre for Palliative Care at Mount Sinai Hospital in Toronto, Ontario. “In these days of budget cutbacks, people are suspicious we just want to speed up death to free up resources.”

Part of an expert team drafting a national framework to better define and guide the use of continuous palliative sedation therapy in Canada, Librach says confusion over when and how to administer the therapy has only served to feed those fears.

“Some physicians aren’t aware of the indications to start treatment, they don’t know how to conduct an appropriate assessment, so they make a wrong diagnosis, they don’t consult the patient or their family and they end up sedating someone with months left to live,” he explains. “Leave a person in it for a week without food or fluid and they’ll die prematurely.”

Without clear guidance, physicians may also prescribe the wrong drugs to achieve sedation, such as opioids, or may not monitor the patient closely enough to ensure they’re properly sedated, says Dr. Doreen Oneschuk, a palliative care physician at Grey Nuns Hospital in Edmonton, Alberta, and a member of the team drafting the framework. “Use the wrong drugs and the patient can end up more agitated or can develop other distressing side effects, like muscle twitches. You also want to make sure you’re titrating fairly quickly because you don’t want to leave someone distressed for hours or administer too much and suppress their respiration.”

Figure

A draft policy framework proposes that continuous palliative sedation therapy only be administered in the last two weeks of life, as a final resort when all other efforts to treat a patient’s suffering have been exhausted and it’s unlikely they will recover to a former level of functioning.

Image courtesy of © 2011 Jupiterimages Corp.

Canadian protocols for administering continuous palliative sedation therapy are largely inconsistent, where such policies exist, says Librach. “Some institutions have guidelines that just focus on which drug to use, some have instructions on how to talk to patients and families, and others have nothing at all. For example, we have a large palliative care program here at Mount Sinai and yet there’s nothing written about this process.”

The absence of a clear definition for continuous palliative sedation therapy — known more ambiguously as “terminal sedation” or “continuous deep sedation” — has also made it difficult to differentiate the legitimate therapy from forms of euthanasia. In Quebec last year, 81% of medical specialists surveyed said they had seen “euthanasia” practised, and 48% said that palliative sedation “can be likened to a form of euthanasia” (www.fmsq.org/magelectronique_1009/e/actualites.html).

The draft framework proposes continuous palliative sedation therapy only be administered in the last two weeks of life, as a final resort when all other efforts to treat a patient’s suffering have been exhausted and it’s unlikely they will recover to a former level of functioning.

Limiting the therapy to the last two weeks of life removes the question of whether it may hasten death, says Librach. “With or without hydration or nutrition, the patient’s trajectory remains the same.”

While the calculation of how long a patient has left to live is more an art than a science, there are often “signposts” to indicate when a patient is rapidly deteriorating, including “weakness increasing day by day or a sudden drop in hunger, thirst or consciousness.”

The draft framework also calls for careful monitoring of the patient, as well as follow up with family and staff, to ensure sedation continues to be appropriate to treat a patient’s suffering up until their death.

“If the patient seems stable, it’s then a question of do we continue treatment or lighten it up to get a better idea of where the patient’s at,” says Librach.

Caution is particularly necessary when assessing a patient for continuous palliative sedation therapy to treat nonphysical suffering, says Blair Henry, a clinical ethicist at Sunnybrook Health Sciences Center in Toronto, Ontario, and a member of the team drafting the framework. “It’s rare that such suffering would be called intolerable and refractory, but it’s part of everyone’s practice experience that you do occasionally meet people who are in such distress or crisis that no intervention of a psychologist or chaplain or any team member can relieve.”

While such cases are most commonly confused for physician-assisted suicide, withholding treatment, as a rule, would not be appropriate, says Librach. “I find it very difficult to separate out. In one case, I knew my patient was going to die a very difficult death with his bowel perforating but up to that point he wouldn’t have much pain. He told me he was suffering waiting for the end, and I told him we would sedate him when the time came. We never were able to control his pain at end-of-life. He has this acute event, no one was standing by his bedside at the ready, and I’ve felt guilty ever since because he died a quick but very horrible, painful death.”

Although patients regularly “walk away from the treatment table,” refusing chemotherapy or dialysis, a patient’s ability to “walk away from their sentience” is decidedly more limited by societal pressures, says Henry. “We’re holding people from therapy they may in fact need because of value judgments we’ve made that a person should find meaning in their suffering.”

The draft framework will be submitted to the Canadian Society of Palliative Care Physicians for review in the coming months. A final version will be published in 2011.

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Canadian Medical Association Journal: 183 (2)
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Vol. 183, Issue 2
8 Feb 2011
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Framework urges physicians to proceed with caution on palliative sedation
Lauren Vogel
CMAJ Feb 2011, 183 (2) 174-175; DOI: 10.1503/cmaj.109-3766

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Framework urges physicians to proceed with caution on palliative sedation
Lauren Vogel
CMAJ Feb 2011, 183 (2) 174-175; DOI: 10.1503/cmaj.109-3766
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