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- Drospirenone and venous thromboembolism; Do prescribing practices impose bias?Show More
Your recent article on drospirenone and venous thromboembolism (VTE) highlighted vast differences between drospirenone and second-generation oral contraceptives (OC) users for smoking [26.28 % versus 18.48%] and obesity [13.41% versus 26.44%] [1]. These differences were not observed in the European Active Surveillance Study which interviewed patients at baseline [2], or the INGENIX study [3], which sampled 10% of patien...
Competing Interests: None declared. - Drospirenone may Increase Thrombosis by Decreasing DHEAShow More
It is my hypothesis that low DHEA may be the cause of venous thrombosis. Low DHEA may be connected with many major symptoms resulting in thrombosis. "Thrombosis May Be Caused by Low DHEA" http://anthropogeny.com/Thrombosis%20May%20Be%20Caused%20by%20Low%20DHEA.htm .
Drospirenone has been demonstrated to reduce DHEAS, the precursor of DHEA, by 20-50% (Contraception 2011; 82: 276-80).
Since the mechan...
Competing Interests: None declared.