Risk of bleeding associated with combined use of selective serotonin reuptake inhibitors and antiplatelet therapy following acute myocardial infarction

Patient characteristics associated with the risk of bleeding during follow-up (Cox regression model with time-dependent exposure). The model was adjusted for exposure to study drugs as presented in Figure 2, and for use of antidepressants other than selective serotonin reuptake inhibitors (SSRIs), use of Hp-PAC to treat Helicobacter pylori infection in year before index admission, use of antiplatelet agents other than acetylsalicylic acid (ASA) and clopidogrel in year before index admission, and use of gastroprotective agents (proton pump inhibitors and histamine-2 receptor antagonists). A hazard ratio greater than 1.0 indicates an increased risk of bleeding. CI = confidence interval, HR = hazard ratio. *Bleeding other than gastrointestinal bleeding or hemorrhagic stroke during the year before the index admission.