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Letter

Oral contraceptives and risk of gallbladder disease

FaZhou Wang, XiaoFeng Shen, XiRong Guo and YuZhu Peng
CMAJ September 20, 2011 183 (13) 1517; DOI: https://doi.org/10.1503/cmaj.111-2065
FaZhou Wang
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XiaoFeng Shen
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XiRong Guo
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YuZhu Peng
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Etminan and colleagues reported on an interesting study in which they found merely a little association between the use of oral contraceptives and gallbladder disease.1 This resembled the results of our recently completed observational study (unpublished data: 2011) in which the cumulative adjusted rate ratio (RR) was 1.01 (95% confidence interval [CI] 0.97–1.12).

However, we found that oral contraceptives are an important contributor to gallbladder disease in patients with a body mass index (BMI) over 30 during drug administration (RR 1.46, 95% CI 1.20–1.79). Etminan and colleagues gave information about the history of obesity but not the weight or BMI of the participants. They also did not perform subgroup analysis on the relationship between a history of obesity and gallbladder disease. Given large differences in diet and somatotypes in Occidental and Asian women, we think their study should have included a subgroup analysis based on demographic characteristics specifically for BMI or weight. Although we concluded from our study that women with a BMI less than 30 should not be concerned about gallbladder problems when taking oral contraceptives, those with a BMI over 30 should be careful.

We want to know whether Etminan and colleagues’ retrospective study could obtain the same results as ours.

Reference

  1. ↵
    1. Etminan M,
    2. Delaney JAC,
    3. Bressler B,
    4. et al
    . Oral contraceptives and the risk of gallbladder disease: a comparative safety study. CMAJ 2011;183:899–904.
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Canadian Medical Association Journal: 183 (13)
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Vol. 183, Issue 13
20 Sep 2011
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Oral contraceptives and risk of gallbladder disease
FaZhou Wang, XiaoFeng Shen, XiRong Guo, YuZhu Peng
CMAJ Sep 2011, 183 (13) 1517; DOI: 10.1503/cmaj.111-2065

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Oral contraceptives and risk of gallbladder disease
FaZhou Wang, XiaoFeng Shen, XiRong Guo, YuZhu Peng
CMAJ Sep 2011, 183 (13) 1517; DOI: 10.1503/cmaj.111-2065
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