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- Statistical Significance is not the same as SignificanceShow More
The recent interesting and beneficial article by Ware et al. [1] has been followed up with a response letter regarding the use of statistical testing [2]. This follow-up letter correctly points out that statements such as “nonsignificant degrees of relief” and “higher but not significant”, are both common in the medical literature and should be avoided [2].
I agree with the points made by Cragg [2], however, I...
Competing Interests: None declared. - Reporting P-values in Clinical Research: Time for a Significant ChangeShow More
I write in response to the well-written and well-supported paper “Smoked cannabis for chronic neuropathic pain: a randomized controlled trial.” The reporting I found troubling, which has become a trend in medical literature was: “preparations with intermediate potency yielded intermediate but nonsignificant degrees of relief.”
This commonly misused phraseology of “higher but not significant” or “lower but no...
Competing Interests: None declared. - Risk of psychosis with medicinal cannabis useShow More
The recent report on cannabis-induced reduction of neuropathic pain by Ware et al. (CMAJ August 30, 2010) received much attention by the press. Unfortunately, in their media interviews, the authors failed to adequately emphasize that the reduction in neuropathic pain was modest as compared to other drugs and efficacy was only demonstrated at the highest dose, along with side effects.
Of particular concern in...
Competing Interests: None declared.