Use of proton pump inhibitors and risk of osteoporosis-related fractures

Figure 1: Association between continuous exposure to proton pump inhibitors and osteoporosis-related fractures (hip, vertebra or wrist). *Adjusted for income, region of residence, diagnoses (short-or long-term diabetes, epilepsy, ischemic heart disease, myocardial infarction, hypertension, arthritis, solid organ transplant, chronic obstructive pulmonary disease, substance use, depression, schizophrenia, dementia), home care use and multiple medications. The reference group was patients with no exposure to proton pump inhibitors or histamine-2-receptor antagonists. Note: CI = confidence interval.