- © 2008 Canadian Medical Association
A 33-year-old HIV-positive man with a history of immune thrombocytopenia presented with a 1-week history of hemoptysis. He had a Pneumocystis jirovecii pneumonia 1 year before, and he had been receiving highly active antiretroviral therapy for 3 months. Multiple violaceous papules and nodules were visible on his back, chest and hard palate (Figure 1A). The patient's platelet count was 16 (normal 140–400) × 109/L, his hemoglobin level was 84 (normal 135–165) g/L, his CD4 count was 66 (normal 500–1400) cells/mm3 and there was an an undetectable viral load. The results of sputum and blood cultures were negative for acid-fast bacilli and other bacteria. A computed tomography scan of his chest (Figure 1B) showed pulmonary nodules with a peribronchovascular ground-glass pattern and bilateral hilar lymphadenopathy.
Figure 1: A: Violaceous papules and nodules on the patient's hard palate. B: Computed tomography scan of the chest showing pulmonary nodules. C: Photograph obtained during a bronchoscopy showing violaceous macular lesions in the patient's upper trachea.
A diagnosis of Kaposi sarcoma was confirmed by a positive immunohistochemistry result for HHV-8. Bronchoscopy (Figure 1C) showed scattered violaceous macular lesions in the patient's upper trachea and more confluent lesions throughout the left and main stem bronchi.
The patient was given dexamethasone and a platelet transfusion, and antiretroviral therapy was continued with the goal of raising his CD4 count. Within 2 weeks, his oral and skin lesions had regressed considerably.
Pulmonary involvement occurs in 6%–32% of HIV patients who have skin manifestations of Kaposi sarcoma and is associated with a median survival of 19 months and a 5-year overall survival rate of 50%.
Footnotes
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