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The Left Atrium

Brand-name disease

Miriam Shuchman
CMAJ March 14, 2006 174 (6) 819-820; DOI: https://doi.org/10.1503/cmaj.060046
Miriam Shuchman
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Selling sickness: How the world's biggest pharmaceutical companies are turning us all into patients Ray Moynihan and Alan Cassels Vancouver/Toronto: Greystone Books, 2006 254 pp $32.95 (cloth) ISBN 1-55365-131-6

In 1999 shyness became a mental illness called social phobia. It wasn't a brand-new diagnosis — the concept had developed over the course of more than 20 years — but now it was on the cover of a US news magazine, in the New York Times and on Good Morning America. Michelle Cottle, an editor at The New Republic, attempted to track the phenomenon and soon learned that SmithKline Beecham (now GlaxoSmithKline) had won FDA approval to market the SSRI antidepressant Paxil as a specific treatment for social phobia.1 The drug company had hired a public relations firm that used a subtle ploy, marketing the disease instead of the drug to win the attention of major media outlets.

Figure1

Figure.

In Selling Sickness: How the World's Biggest Pharmaceutical Companies are Turning Us All into Patients, Ray Moynihan, an investigative reporter who is a frequent contributor to BMJ, and Alan Cassels, a drug policy researcher at the University of Victoria, take us behind the scenes of the social phobia marketing campaign, explaining that, „In keeping with modern public relations techniques, the PR firm helped orchestrate what looked like a grassroots movement to raise public awareness about a neglected disorder.”

Those looks were deceiving. Although it appeared as if the American Psychiatric Association and patient advocacy groups such as the Anxiety Disorders Association of America had joined forces to inform the public about an important mental health problem, the social phobia campaign was actually managed, Moynihan and Cassels claim, by Cohn & Wolfe Healthcare, SmithKline's PR firm. It seems that the strategy was extraordinarily effective. Paxil became the world's best-selling antidepressant, earning US$3 billion annually. To anyone who's ever wondered why a disorder keeps popping up in headlines or on television, this story is a revelation.

Moynihan and Cassels are at their best when giving us this sort of inside dope about the drug industry's marketing tactics, and they've gathered a lot of it for this book and a related film documentary. Their thesis is that the marketing strategy for Paxil is but one example of a widespread phenomenon in which pharmaceutical companies market diseases, then convince naive consumers that they have the disease and need medication for it. Selling Sickness describes similar efforts surrounding prescriptions for ten medical and psychiatric conditions, including osteoporosis, hypertension and something called female sexual dysfunction. In each case, Moynihan and Cassels spotlight the industry's efforts and then spell out the downside risks. Merck's strategy to increase sales of Fosamax had harmful consequences, they write, because it led doctors to neglect non-drug approaches, such as exercise to decrease the risk of fractures among women with osteoporosis. Manufacturers of calcium-channel blockers encouraged doctors to prescribe that class of antihypertensives, with the result that „collectively the world is wasting billions on the most expensive blood pressure drugs” when cheaper generics would work as well or better.

The notion that illness is shaped or even created by cultural and economic forces isn't new and has been covered by other books reviewed in these pages.2,3 However, Selling Sickness stands out for its investigation into the role of the drug industry in this process. At the same time, Moynihan and Cassels can be faulted for tunnel vision. Their unified focus on Big Pharma's marketing techniques, while fascinating, leaves out other crucial factors in the construction of illness, resulting in an account that is at times polemical and overly simplistic. Let's return to social phobia for a moment. Selling Sickness leaves the impression that this disorder is almost entirely the result of a PR firm's savvy strategizing. But social phobia is a real phenomenon that deserves a more nuanced account. It was first listed as a disorder in the Diagnostic and Statistical Manual of Mental Disorders in 1980, and by the mid-1990s both the National Institute of Mental Health and drug companies were funding research on it. Epidemiologic studies described people with social phobia as painfully shy, to the point that they had few friends, dropped out of school, didn't work, had trouble dating and didn't marry. Whether or not it qualified as a disorder, people suffered from it and sought help to improve their social skills and quality of life. Then came the FDA's approval of Paxil for social phobia, followed by SmithKline's awareness campaign and the media coverage it generated. Shy people across the US perked up their ears. They had been „listening to Prozac” and the buzz around it but hadn't realized that the new class of antidepressants might help them, too.

Moynihan and Cassels describe one such individual, an unemployed California woman named Deborah who was nervous about job interviews. After seeing a commercial on television that described social anxiety disorder and mentioned Paxil, she went to the doctor, got a prescription and landed a job in real estate that she held for four years. „I think taking the medication helped me be able to work with the public in a comfortable way,” she said. She was pleased until she experienced Paxil's difficult withdrawal syndrome — a problem that neither doctors nor patients were aware of initially. (In 2002 the FDA issued a warning that Paxil can cause severe withdrawal symptoms.)

In their zeal to drive home their message, Moynihan and Cassels mock Deborah's difficulties and her reliance on an antidepressant. „With her successful self-diagnosis of social anxiety disorder,” they write, „Deborah was at the frontier of medical science — her condition had only just been pushed from the shadows of obscurity into the glare of the public spotlight, and the powerful antidepressant Paxil had just become the first drug ever approved to treat it.”

The authors are equally derisive in their description of Murray Stein, a psychiatrist who began studying social phobia while at the University of Manitoba in the early 1990s and later ran clinical trials testing the effectiveness of Paxil and other drugs for the disorder. Stein also wrote a popular book that lists exercises to help people overcome shyness, but in the hands of Moynihan and Cassels he's little more than a mouthpiece for SmithKline, because he ran company-sponsored trials and „offered flattering praise for Paxil” in company press releases.

Moynihan and Cassels have amassed a wealth of information, and their writing is entertaining and easy to follow, but they might have achieved more if they had been willing to look beyond Big Pharma. The reasons people take drugs — prescription or otherwise — are complex and not easily boiled down. In a recent issue of Salon, David Amdsen speculates on the current popularity of SSRIs and psychostimulants and concludes that they are being used as performance-enhancing substances. It's an outlandish suggestion that involves doctors and patients as much or more than drug companies, and he just could be right.

REFERENCES

  1. 1.↵
    Michelle C. Selling shyness. How doctors and drug companies created the „social phobia” epidemic. New Repub 1999;(Aug 2):22-9.
  2. 2.↵
    Deshauer D. Disease as idea [book review]. CMAJ 2005;173(7):790-1.
    OpenUrlFREE Full Text
  3. 3.↵
    Garland E J. Bitter pills [book review]. CMAJ2004;171(11):1374-5.
    OpenUrlFREE Full Text
  4. 4.
    Amsden D. Life: the disorder. Salon 2005; Nov 25. Available: www.salon.com (accessed 2006 Feb 20).
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Canadian Medical Association Journal: 174 (6)
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14 Mar 2006
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CMAJ Mar 2006, 174 (6) 819-820; DOI: 10.1503/cmaj.060046

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