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Review

Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effects

Andrea D. Furlan, Juan A. Sandoval, Angela Mailis-Gagnon and Eldon Tunks
CMAJ May 23, 2006 174 (11) 1589-1594; DOI: https://doi.org/10.1503/cmaj.051528
Andrea D. Furlan
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Juan A. Sandoval
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Angela Mailis-Gagnon
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Eldon Tunks
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    Files in this Data Supplement:

    • Appendix 1: Search strategy for MEDLINE
    • Appendix 2: Search strategy for EMBASE
    • Appendix 3: Flow diagram according to the QUORUM guidelines.
    • Appendix 4A: Characteristics of randomized, placebo-controlled trials involving patients with neuropathic pain that were included in the meta-analysis
    • Appendix 4B: Characteristics of randomized, placebo-controlled trials involving patients with nociceptive pain that were included in the meta-analysis
    • Appendix 4C: Characteristics of randomized, placebo-controlled trials involving patients with fibromyalgia or mixed neuropathic and nociceptive pain and an N-of-1 trial that were included in the meta-analysis
    • Appendix 4D: Characteristics of randomized trials comparing opioids with other analgesics that were included in the meta-analysis
    • Appendix 5: Effectiveness of opioids (all types) versus placebo for chronic non–cancer-related pain (higher values = worse pain).
    • Appendix 6: Sensitivity analyses of opioids versus placebo
    • Appendix 7: Cumulative random-effects meta-analysis of pain outcomes in 28 placebo-controlled trials investigating opioid analgesics. SMD = standardized mean difference.
    • Appendix 8: Effectiveness of opioids (all types) versus placebo for function outcomes (higher values = more disabled), by type of drug.
    • Appendix 9: Cumulative random-effects meta-analysis of 20 placebo-controlled trials of opioids with function as a primary outcome.
    • Appendix 10: Effectiveness of opioids (all types) versus nonsteroidal anti-inflammatory drugs and tricyclic antidepressants for chronic non–cancer-related pain (higher values = worse pain).
    • Appendix 11: Sensitivity analyses* of opioids versus other drugs for pain relief
    • Appendix 12: Effectiveness of opioids (all types) versus nonsteroidal anti-inflammatory drugs and tricyclic antidepressants for function outcomes (higher values = more disabled).

Related Articles

  • (2006). Highlights of this issue. CMAJ, 174(11), 1541. Accessed September 22, 2023. Retrieved from http://www.cmaj.ca/content/174/11/1541.1.
  • (2006). Dans ce numéro. CMAJ, 174(11), 1541-1541-a. Accessed September 22, 2023. Retrieved from http://www.cmaj.ca/content/174/11/1541.2.
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Canadian Medical Association Journal: 174 (11)
CMAJ
Vol. 174, Issue 11
23 May 2006
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Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effects
Andrea D. Furlan, Juan A. Sandoval, Angela Mailis-Gagnon, Eldon Tunks
CMAJ May 2006, 174 (11) 1589-1594; DOI: 10.1503/cmaj.051528

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Opioids for chronic noncancer pain: a meta-analysis of effectiveness and side effects
Andrea D. Furlan, Juan A. Sandoval, Angela Mailis-Gagnon, Eldon Tunks
CMAJ May 2006, 174 (11) 1589-1594; DOI: 10.1503/cmaj.051528
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  • Optimal Strategies for Reporting Pain in Clinical Trials and Systematic Reviews: Recommendations from an OMERACT 12 Workshop
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  • Opioids for chronic noncancer pain: A position paper of the American Academy of Neurology
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  • The Efficacy and Safety of Opioids in Inflammatory Arthritis: A Cochrane Systematic Review
  • Canadian guideline for safe and effective use of opioids for chronic noncancer pain: Clinical summary for family physicians. Part 1: general population
  • Lignes directrices canadiennes sur l'utilisation securitaire et efficace des opioides pour la douleur chronique non cancereuse: Resume clinique pour les medecins de famille. Partie 1: population en general
  • Devrions-nous prescrire des opioides pour la douleur chronique non cancereuse?
  • Should we prescribe opioids for chronic noncancer pain?
  • Pharmacotherapy of fibromyalgia
  • Clustering of opioid prescribing--what is really going on?
  • Chronic noncancer pain: Characteristics of patients prescribed opioids by community physicians and referred to a tertiary pain clinic
  • What we still don't know about treating chronic noncancer pain with opioids
  • Opioids for chronic noncancer pain: a new Canadian practice guideline
  • Chronic Opioid Therapy and Preventive Services in Rural Primary Care: An Oregon Rural Practice-based Research Network Study
  • A sailor's pain: Veterans' musculoskeletal disorders, chronic pain, and disability
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