Fig. 2: A diagram depicting the colinearity of the genomes of B. bronchiseptica (BB) and B. parapertussis (BPa) and B. bronchiseptica and B. pertussis (BP). Regions of the 2 genomes that contain identical DNA are joined by red lines. Thus, vertical red lines represent regions that are present at the same point in both genomes. Slanted red lines represent regions that are present in both genomes, but at different locations. Black triangles show the locations of IS elements in each genome. Note that many genomic regions that have moved location in the B. pertussis or B. parapertussis genomes when compared with B. bronchiseptica are flanked by IS elements, indicating that these repeats are important foci of genomic reorganization in B. pertussis and B. parapertussis. The diagram was generated using the Artemis Comparison Tool (www.sanger.ac.uk/Software/ACT/) and is reproduced, with permission, from Parkhill J, Sebaihia M, Preston A, Murphy LD, Thomson N, Harris DE, et al. Comparative analysis of the genome sequences of Bordetella pertussis, Bordetella parapertussis and Bordetella bronchiseptica. Nat Genet 2003;35:32-40.