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Research article

Relation between randomized controlled trials published in leading general medical journals and the global burden of disease

Paula A. Rochon, Azad Mashari, Ariel Cohen, Anjali Misra, Dara Laxer, David L. Streiner, Julie M. Dergal, Jocalyn P. Clark, Jennifer Gold and Malcolm A. Binns
CMAJ May 25, 2004 170 (11) 1673-1677; DOI: https://doi.org/10.1503/cmaj.1031006
Paula A. Rochon
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Azad Mashari
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Ariel Cohen
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Anjali Misra
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Dara Laxer
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David L. Streiner
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Julie M. Dergal
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Jocalyn P. Clark
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Jennifer Gold
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Malcolm A. Binns
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  • Publishing on global burden of disease � how to find peer reviewers?
    Ana Marusic
    Posted on: 06 December 2004
  • Burden of global disease-where is severe sepsis?
    Harold N Fisher
    Posted on: 06 October 2004
  • Social Relevance of Research
    sonal singh
    Posted on: 19 July 2004
  • Catering to the customers
    Louis B Jacques MD
    Posted on: 02 June 2004
  • Posted on: (6 December 2004)
    Page navigation anchor for Publishing on global burden of disease � how to find peer reviewers?
    Publishing on global burden of disease � how to find peer reviewers?
    • Ana Marusic

    Rochon et al1 call for better balance between global burden of disease and published clinical trials in leading general medical journals. In extending their coverage to global health issues, large western medical journals may have difficulties in finding reviewers from small research communities. We surveyed 236 (63.8%) tenur...

    Show More

    Rochon et al1 call for better balance between global burden of disease and published clinical trials in leading general medical journals. In extending their coverage to global health issues, large western medical journals may have difficulties in finding reviewers from small research communities. We surveyed 236 (63.8%) tenure faculty members from four medical schools in Croatia, a small country with specific burden of disease,2 about their willingness to review and criteria they would use in reviewing manuscripts for a large journal, such as TheLancet, and the small Croatian Medical Journal (CMJ).3 Half of the respondents had not published in either journal and only 4.2% in both journals. A few respondents (9.8%) were not interested in reviewing for either journal, and only a single one expressed the wish to review for TheLancet but not for the CMJ (Table). A surprising 71.6% of respondents would review only for the CMJ and further 18.2% would review for both journals, stating that they would be either equally strict reviewers for both journals or stricter for TheLancet (Table). Respondents who wanted to review for The Lancet were less experienced reviewers who read TheLancet but thought that reviewer’s recommendations were not important for editorial decisions. Our survey results are valid only for Croatia, but may be indicative of beliefs of researchers in other less developed research communities. The bridging of the publishing gap between the global burden of disease and Western medical journals may not be so easy, and the journals should take an active role in building research and publishing capacity in the developing world. Understanding the behaviour, perceptions, and concerns of potential reviewers in small scientific communities may facilitate the identification of good reviewers and finally result in most relevant publications in the area of international health.

    Ana Marusic, Darko Hren, Matko Marusic

    Croatian Medical Journal,Zagreb University School of Medicine

    Šalata 3, 10000 Zagreb, Croatia

    References

    1.      Rochon PA, Mashari A, Cohen A, Misra A, Laxer D, Streiner DL, Dergal JM, Clark JP. Gold J, Binns MA. Relation between randomized controlled trials published in leading general medical journals and the global burden of disease. CMAJ 2004;170(11):1673-7.

    2.      Katic M, Juresa V, Oreskovic S. Family medicine in Croatia: past, present, and forthcoming challenges. Croat Med J 2004;45(5):543-9.

    1.      Marusic A, Lukic IK, Marusic M, McNamee D, Sharp D, Horton R. Peer review in a small and a big medical journal: case study of the Croatian Medical Journal and The Lancet. Croat Med J 2002;43(3):286–9.

    Table.Willingness of Croatian medical faculty (n=236) to review for TheLancet and Croatian Medical Journal (CMJ) and their review criteria

    Question

    No. (%)

    Willingness to review for:

     

    neither CMJ nor The Lancet

    23 (9.8)

    CMJ only

    169 (71.6)

    The Lancet only

    1 (0.4)

    Both

    43 (18.2)

    Review criteria:

     

    equally strict for both journals

    193 (81.8)

    stricter for TheLancet

    42 (17.8)

    stricter for CMJ

    1 (0.4)

    Peer review is important for:*

     

    editorial decision about publication of the manuscript

    4.0±0.6

    research in general

    4.8±0.5

    Satisfaction with previous reviews as authors*

    3.8±0.7

    *Scores (mean ± standard deviation) are based on a 5-point Likert scale (1 = strongly disagree or greatly dissatisfied and 5 = strongly agree or greatly satisfied).

    Conflict of Interest:

    None declared

    Show Less
    Competing Interests: None declared.
  • Posted on: (6 October 2004)
    Page navigation anchor for Burden of global disease-where is severe sepsis?
    Burden of global disease-where is severe sepsis?
    • Harold N Fisher, 3650 Danforth Ave, Toronto, M1N 2E8

    I have read with interest the article: "Relation between randomized controlled trials published in leading general medical journals and the global burden of disease" in the May issue. However it is curious that severe sepsis is not listed as a leading cause of death and disablity. One recent pivotal publication analysed data from administrative databases in 1995, and concluded that the incidence of severe sepsis was ap...

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    I have read with interest the article: "Relation between randomized controlled trials published in leading general medical journals and the global burden of disease" in the May issue. However it is curious that severe sepsis is not listed as a leading cause of death and disablity. One recent pivotal publication analysed data from administrative databases in 1995, and concluded that the incidence of severe sepsis was approximately 750,000 cases, and responsible for 250,000 deaths annually in the U.S.(1) This puts the burden of severe sepsis on par with the sudden deaths from acute myocardial infarction as a leading cause of death. Other epidemiological papers have come to similar conclusions. It would be interesting to understand the conclusions of this paper in the context of these data.

    1. Angus DC et al; "Epidemiology of Severe Sepsis in the United States: Analysis of Incidence, Outcome, and Associated Costs of Care." Critical Care Medicine; V.29; No.7; 2001; p1303

    Conflict of Interest:

    Receive income from and shareholder Eli Lilly

    Show Less
    Competing Interests: None declared.
  • Posted on: (19 July 2004)
    Page navigation anchor for Social Relevance of Research
    Social Relevance of Research
    • sonal singh

    I read with interest the wonderful article by Rochon and colleagues (1), which concluded that many diseases common internationally are underrepresented in RCTs published in general medical journals and identified barriers to information exchange responsible for this phenomenon. I believe that the present measures of assessing research performance may also have contributed to this 10/90 gap in publishing.

    Most o...

    Show More

    I read with interest the wonderful article by Rochon and colleagues (1), which concluded that many diseases common internationally are underrepresented in RCTs published in general medical journals and identified barriers to information exchange responsible for this phenomenon. I believe that the present measures of assessing research performance may also have contributed to this 10/90 gap in publishing.

    Most of research that scientists judge to be of high quality- meaning original thought and method ,has very little impact on health (2). Besides the widepread use of the impact factor for assessing the quality of journals has its own limitations(2). A research on a novel protein that affects some fancy chemical in the blood may be adjudged to be of high quality. In contrast, research on foot-care for frail elderly people, which may have widespread immediate and important social impact will not receive much attention (3)in the present scheme of things.

    The results of this article clearly calls for a renewed debate on the current measures of research performance. We need new measures, which take into account not only the quality of scietific articles but also incorporate the social impact of research .This will enable us to reduce inequalities and fulfill the main goal of health research which is to improve the health of people.

    REFERENCES

    1. Rochon PA, Mashari A, Cohen A, Misra A, Laxer D, Streiner DL, et al. Relation between randomized controlled trials published in leading general medical journals and the global burden of disease. CMAJ 2004;170(11):1673-7.

    2. Smith R. Measuring the social impact of research. BMJ. 2001 Sep 8; 323(7312):528

    3. Caan W. Inequalities and research need to be balanced. BMJ, January 5, 2002; 324(7328): 51 - 51

    Conflict of Interest:

    None declared

    Show Less
    Competing Interests: None declared.
  • Posted on: (2 June 2004)
    Page navigation anchor for Catering to the customers
    Catering to the customers
    • Louis B Jacques MD

    It is not surprising that six English language journals edited in North America and the UK would tend to publish on topics of interest to English spreaking patients, physicians and researchers in those industrialized, relatively wealthy countries. Grant funding and the subsequent generation of manuscripts, driven by public/political advocacy and commercial interests, probably reinforce this practice.

    This is n...

    Show More

    It is not surprising that six English language journals edited in North America and the UK would tend to publish on topics of interest to English spreaking patients, physicians and researchers in those industrialized, relatively wealthy countries. Grant funding and the subsequent generation of manuscripts, driven by public/political advocacy and commercial interests, probably reinforce this practice.

    This is not necessarily good or bad, simply a reflection of the professional interests of the readers. One could argue that these journals survive by focusing the bulk of their output on topics that are of interest to their revenue stream of subscribers and advertisers-that's really just good business practice.

    The conduct and dissemination of RCTs that are more focused on world health priorities may ultimately depend on the development of a comparable research and publishing infrastructure in those less affluent countries. Admittedly this is a daunting task.

    Conflict of Interest:

    None declared

    Show Less
    Competing Interests: None declared.
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Canadian Medical Association Journal: 170 (11)
CMAJ
Vol. 170, Issue 11
25 May 2004
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Relation between randomized controlled trials published in leading general medical journals and the global burden of disease
Paula A. Rochon, Azad Mashari, Ariel Cohen, Anjali Misra, Dara Laxer, David L. Streiner, Julie M. Dergal, Jocalyn P. Clark, Jennifer Gold, Malcolm A. Binns
CMAJ May 2004, 170 (11) 1673-1677; DOI: 10.1503/cmaj.1031006

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Relation between randomized controlled trials published in leading general medical journals and the global burden of disease
Paula A. Rochon, Azad Mashari, Ariel Cohen, Anjali Misra, Dara Laxer, David L. Streiner, Julie M. Dergal, Jocalyn P. Clark, Jennifer Gold, Malcolm A. Binns
CMAJ May 2004, 170 (11) 1673-1677; DOI: 10.1503/cmaj.1031006
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