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News and analysis

Gene mutation may explain multiple-birth pregnancies

CMAJ January 09, 2001 164 (1) 82-82-a;
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The recent discovery (Lancet 2000;356:914) of a gene mutation thought to be responsible for multiple-birth pregnancies could mark the first step in developing a test to identify women at increased risk of having twins and triplets.

By using DNA tests on blood samples from a woman who has given birth to 2 sets of twins and has a family history of multiple pregnancies over 2 generations, Dr. Valter Feyles and colleagues from McMaster University identified a pair of gene defects that appear to increase the sensitivity of the receptor site where follicle-stimulating hormone (FSH) binds with the ovaries. This heightened sensitivity may cause the ovaries to release more than 1 egg during ovulation, causing a multiple pregnancy. The mutation was not found in blood samples taken from the 34 women in the control group, all of whom had just 1 baby per pregnancy and no family history of twinning.

If borne out in larger-scale studies, say researchers, the finding could lead to more effective treatment. “Early identification of women carrying the gene defect would allow doctors to adjust fertility medication to reduce risk of multiple-birth pregnancies,” said Feyles. — Greg Basky, Saskatoon

Figure1

Figure.

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CMAJ
Vol. 164, Issue 1
9 Jan 2001
  • Table of Contents
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  • Canadian Adverse Drug Reaction Newsletter (91-98)

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