Research article
Comparison of human papillomavirus DNA testing and repeat Papanicolaou test in women with low-grade cervical cytologic abnormalities: a randomized trial
Alice Lytwyn, John W. Sellors, James B. Mahony, Dean Daya, William Chapman, Noella Ellis, Paula Roth, Attila T. Lorincz, Amiran Gafni and The HPV Effectiveness in Lowgrade Paps (HELP) Study No. 1 Group
CMAJ September 19, 2000 163 (6) 701-707;
Alice Lytwyn
From *the Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ont.; the Departments of †Family Medicine, ‡Clinical Epidemiology and Biostatistics, §Pathology and Molecular Medicine, and Obstetrics and Gynecology, McMaster University, Hamilton, Ont.; **the Father Sean O'Sullivan Research Centre, Hamilton, Ont.; and ††the Digene Corporation, Beltsville, Md. Principal investigators: Alice Lytwyn, John W. Sellors, James B. Mahony, Dean Daya, William Chapman, Noella Ellis, Paula Roth, Attila T. Lorincz, Amiran Gafni. Family practitioners: Nancy L. Abram, Jane E. Anwan, Michael P. Cameron, Larry H. Cowan, David Cree, Andrea Csordas, Nicholas W. Doroszkiewicz, Jennifer Everson, Finola Foley, Peter T. Ford, Elizabeth C. Galbraith, Sameera Ghaznavi, Bronislaw Golda, Allen S. Greenspoon, Alfred B. Gudgeon, Janice A. Harvey, Katalin E. Ivanyi, B. Darrel Juriansz, Allan A. Kopyto, Anne S. Lapinsky, Sheila Mason, Kimberley C. McCallum, S. Kim McMillan, E. Lynn Nash, Rosanne Nishimura, Christopher H. Ragonetti, Marilyn S. Robertson, Matthew G. Robinson, B. Karen Selwyn, J. Elaine Serena, Anne E. Shaw, Philip E. Shea, Marie B. Syty-Golda, Iwona R. Tarasiewicz, Vernon M. Toyonaga, William B. Watters, Mark L. Waxman, Norma A. Wright, Joel W. Yellin, Janice L. Young, Richard A. Zizzo. Pathologists: Vicky S.M. Chen, Laurence Day, Franco G. Denardi, John Doucet, Terence J. D'Souza, Leelamma J. Elavathil, Bernard J.J. Fernandes, Geoffrey W. Gardiner, R. Warren J. Hartwick, Suhas B. Joshi, Linda R. Kapusta, Norbert A. Kerenyi, Arnost Kolin, King S. Lee, Francesca V. Lobo, Alan Medline, Izabella Morava-Protzner, Brendan J. Mullen, Keith F. Oliveira, Ali H. Qizilbash, Solomon Rabinovich, John T. Roberts, Laila M.I. Sabet, Jose Segura, Ralph W. Shaw, Tasmin K. Sheikh, Hafez S. Shuhaibar, John R. Srigley, Paul S. Thorner. Colposcopists: Richard E. Kalbfleisch, John A. Lamont, Margaret R. Lightheart, Lawrence W. Loopstra, John L. Mazurka, Francois Moens, Donald C. Robinson
John W. Sellors
From *the Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ont.; the Departments of †Family Medicine, ‡Clinical Epidemiology and Biostatistics, §Pathology and Molecular Medicine, and Obstetrics and Gynecology, McMaster University, Hamilton, Ont.; **the Father Sean O'Sullivan Research Centre, Hamilton, Ont.; and ††the Digene Corporation, Beltsville, Md. Principal investigators: Alice Lytwyn, John W. Sellors, James B. Mahony, Dean Daya, William Chapman, Noella Ellis, Paula Roth, Attila T. Lorincz, Amiran Gafni. Family practitioners: Nancy L. Abram, Jane E. Anwan, Michael P. Cameron, Larry H. Cowan, David Cree, Andrea Csordas, Nicholas W. Doroszkiewicz, Jennifer Everson, Finola Foley, Peter T. Ford, Elizabeth C. Galbraith, Sameera Ghaznavi, Bronislaw Golda, Allen S. Greenspoon, Alfred B. Gudgeon, Janice A. Harvey, Katalin E. Ivanyi, B. Darrel Juriansz, Allan A. Kopyto, Anne S. Lapinsky, Sheila Mason, Kimberley C. McCallum, S. Kim McMillan, E. Lynn Nash, Rosanne Nishimura, Christopher H. Ragonetti, Marilyn S. Robertson, Matthew G. Robinson, B. Karen Selwyn, J. Elaine Serena, Anne E. Shaw, Philip E. Shea, Marie B. Syty-Golda, Iwona R. Tarasiewicz, Vernon M. Toyonaga, William B. Watters, Mark L. Waxman, Norma A. Wright, Joel W. Yellin, Janice L. Young, Richard A. Zizzo. Pathologists: Vicky S.M. Chen, Laurence Day, Franco G. Denardi, John Doucet, Terence J. D'Souza, Leelamma J. Elavathil, Bernard J.J. Fernandes, Geoffrey W. Gardiner, R. Warren J. Hartwick, Suhas B. Joshi, Linda R. Kapusta, Norbert A. Kerenyi, Arnost Kolin, King S. Lee, Francesca V. Lobo, Alan Medline, Izabella Morava-Protzner, Brendan J. Mullen, Keith F. Oliveira, Ali H. Qizilbash, Solomon Rabinovich, John T. Roberts, Laila M.I. Sabet, Jose Segura, Ralph W. Shaw, Tasmin K. Sheikh, Hafez S. Shuhaibar, John R. Srigley, Paul S. Thorner. Colposcopists: Richard E. Kalbfleisch, John A. Lamont, Margaret R. Lightheart, Lawrence W. Loopstra, John L. Mazurka, Francois Moens, Donald C. Robinson
James B. Mahony
From *the Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ont.; the Departments of †Family Medicine, ‡Clinical Epidemiology and Biostatistics, §Pathology and Molecular Medicine, and Obstetrics and Gynecology, McMaster University, Hamilton, Ont.; **the Father Sean O'Sullivan Research Centre, Hamilton, Ont.; and ††the Digene Corporation, Beltsville, Md. Principal investigators: Alice Lytwyn, John W. Sellors, James B. Mahony, Dean Daya, William Chapman, Noella Ellis, Paula Roth, Attila T. Lorincz, Amiran Gafni. Family practitioners: Nancy L. Abram, Jane E. Anwan, Michael P. Cameron, Larry H. Cowan, David Cree, Andrea Csordas, Nicholas W. Doroszkiewicz, Jennifer Everson, Finola Foley, Peter T. Ford, Elizabeth C. Galbraith, Sameera Ghaznavi, Bronislaw Golda, Allen S. Greenspoon, Alfred B. Gudgeon, Janice A. Harvey, Katalin E. Ivanyi, B. Darrel Juriansz, Allan A. Kopyto, Anne S. Lapinsky, Sheila Mason, Kimberley C. McCallum, S. Kim McMillan, E. Lynn Nash, Rosanne Nishimura, Christopher H. Ragonetti, Marilyn S. Robertson, Matthew G. Robinson, B. Karen Selwyn, J. Elaine Serena, Anne E. Shaw, Philip E. Shea, Marie B. Syty-Golda, Iwona R. Tarasiewicz, Vernon M. Toyonaga, William B. Watters, Mark L. Waxman, Norma A. Wright, Joel W. Yellin, Janice L. Young, Richard A. Zizzo. Pathologists: Vicky S.M. Chen, Laurence Day, Franco G. Denardi, John Doucet, Terence J. D'Souza, Leelamma J. Elavathil, Bernard J.J. Fernandes, Geoffrey W. Gardiner, R. Warren J. Hartwick, Suhas B. Joshi, Linda R. Kapusta, Norbert A. Kerenyi, Arnost Kolin, King S. Lee, Francesca V. Lobo, Alan Medline, Izabella Morava-Protzner, Brendan J. Mullen, Keith F. Oliveira, Ali H. Qizilbash, Solomon Rabinovich, John T. Roberts, Laila M.I. Sabet, Jose Segura, Ralph W. Shaw, Tasmin K. Sheikh, Hafez S. Shuhaibar, John R. Srigley, Paul S. Thorner. Colposcopists: Richard E. Kalbfleisch, John A. Lamont, Margaret R. Lightheart, Lawrence W. Loopstra, John L. Mazurka, Francois Moens, Donald C. Robinson
Dean Daya
From *the Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ont.; the Departments of †Family Medicine, ‡Clinical Epidemiology and Biostatistics, §Pathology and Molecular Medicine, and Obstetrics and Gynecology, McMaster University, Hamilton, Ont.; **the Father Sean O'Sullivan Research Centre, Hamilton, Ont.; and ††the Digene Corporation, Beltsville, Md. Principal investigators: Alice Lytwyn, John W. Sellors, James B. Mahony, Dean Daya, William Chapman, Noella Ellis, Paula Roth, Attila T. Lorincz, Amiran Gafni. Family practitioners: Nancy L. Abram, Jane E. Anwan, Michael P. Cameron, Larry H. Cowan, David Cree, Andrea Csordas, Nicholas W. Doroszkiewicz, Jennifer Everson, Finola Foley, Peter T. Ford, Elizabeth C. Galbraith, Sameera Ghaznavi, Bronislaw Golda, Allen S. Greenspoon, Alfred B. Gudgeon, Janice A. Harvey, Katalin E. Ivanyi, B. Darrel Juriansz, Allan A. Kopyto, Anne S. Lapinsky, Sheila Mason, Kimberley C. McCallum, S. Kim McMillan, E. Lynn Nash, Rosanne Nishimura, Christopher H. Ragonetti, Marilyn S. Robertson, Matthew G. Robinson, B. Karen Selwyn, J. Elaine Serena, Anne E. Shaw, Philip E. Shea, Marie B. Syty-Golda, Iwona R. Tarasiewicz, Vernon M. Toyonaga, William B. Watters, Mark L. Waxman, Norma A. Wright, Joel W. Yellin, Janice L. Young, Richard A. Zizzo. Pathologists: Vicky S.M. Chen, Laurence Day, Franco G. Denardi, John Doucet, Terence J. D'Souza, Leelamma J. Elavathil, Bernard J.J. Fernandes, Geoffrey W. Gardiner, R. Warren J. Hartwick, Suhas B. Joshi, Linda R. Kapusta, Norbert A. Kerenyi, Arnost Kolin, King S. Lee, Francesca V. Lobo, Alan Medline, Izabella Morava-Protzner, Brendan J. Mullen, Keith F. Oliveira, Ali H. Qizilbash, Solomon Rabinovich, John T. Roberts, Laila M.I. Sabet, Jose Segura, Ralph W. Shaw, Tasmin K. Sheikh, Hafez S. Shuhaibar, John R. Srigley, Paul S. Thorner. Colposcopists: Richard E. Kalbfleisch, John A. Lamont, Margaret R. Lightheart, Lawrence W. Loopstra, John L. Mazurka, Francois Moens, Donald C. Robinson
William Chapman
From *the Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ont.; the Departments of †Family Medicine, ‡Clinical Epidemiology and Biostatistics, §Pathology and Molecular Medicine, and Obstetrics and Gynecology, McMaster University, Hamilton, Ont.; **the Father Sean O'Sullivan Research Centre, Hamilton, Ont.; and ††the Digene Corporation, Beltsville, Md. Principal investigators: Alice Lytwyn, John W. Sellors, James B. Mahony, Dean Daya, William Chapman, Noella Ellis, Paula Roth, Attila T. Lorincz, Amiran Gafni. Family practitioners: Nancy L. Abram, Jane E. Anwan, Michael P. Cameron, Larry H. Cowan, David Cree, Andrea Csordas, Nicholas W. Doroszkiewicz, Jennifer Everson, Finola Foley, Peter T. Ford, Elizabeth C. Galbraith, Sameera Ghaznavi, Bronislaw Golda, Allen S. Greenspoon, Alfred B. Gudgeon, Janice A. Harvey, Katalin E. Ivanyi, B. Darrel Juriansz, Allan A. Kopyto, Anne S. Lapinsky, Sheila Mason, Kimberley C. McCallum, S. Kim McMillan, E. Lynn Nash, Rosanne Nishimura, Christopher H. Ragonetti, Marilyn S. Robertson, Matthew G. Robinson, B. Karen Selwyn, J. Elaine Serena, Anne E. Shaw, Philip E. Shea, Marie B. Syty-Golda, Iwona R. Tarasiewicz, Vernon M. Toyonaga, William B. Watters, Mark L. Waxman, Norma A. Wright, Joel W. Yellin, Janice L. Young, Richard A. Zizzo. Pathologists: Vicky S.M. Chen, Laurence Day, Franco G. Denardi, John Doucet, Terence J. D'Souza, Leelamma J. Elavathil, Bernard J.J. Fernandes, Geoffrey W. Gardiner, R. Warren J. Hartwick, Suhas B. Joshi, Linda R. Kapusta, Norbert A. Kerenyi, Arnost Kolin, King S. Lee, Francesca V. Lobo, Alan Medline, Izabella Morava-Protzner, Brendan J. Mullen, Keith F. Oliveira, Ali H. Qizilbash, Solomon Rabinovich, John T. Roberts, Laila M.I. Sabet, Jose Segura, Ralph W. Shaw, Tasmin K. Sheikh, Hafez S. Shuhaibar, John R. Srigley, Paul S. Thorner. Colposcopists: Richard E. Kalbfleisch, John A. Lamont, Margaret R. Lightheart, Lawrence W. Loopstra, John L. Mazurka, Francois Moens, Donald C. Robinson
Noella Ellis
From *the Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ont.; the Departments of †Family Medicine, ‡Clinical Epidemiology and Biostatistics, §Pathology and Molecular Medicine, and Obstetrics and Gynecology, McMaster University, Hamilton, Ont.; **the Father Sean O'Sullivan Research Centre, Hamilton, Ont.; and ††the Digene Corporation, Beltsville, Md. Principal investigators: Alice Lytwyn, John W. Sellors, James B. Mahony, Dean Daya, William Chapman, Noella Ellis, Paula Roth, Attila T. Lorincz, Amiran Gafni. Family practitioners: Nancy L. Abram, Jane E. Anwan, Michael P. Cameron, Larry H. Cowan, David Cree, Andrea Csordas, Nicholas W. Doroszkiewicz, Jennifer Everson, Finola Foley, Peter T. Ford, Elizabeth C. Galbraith, Sameera Ghaznavi, Bronislaw Golda, Allen S. Greenspoon, Alfred B. Gudgeon, Janice A. Harvey, Katalin E. Ivanyi, B. Darrel Juriansz, Allan A. Kopyto, Anne S. Lapinsky, Sheila Mason, Kimberley C. McCallum, S. Kim McMillan, E. Lynn Nash, Rosanne Nishimura, Christopher H. Ragonetti, Marilyn S. Robertson, Matthew G. Robinson, B. Karen Selwyn, J. Elaine Serena, Anne E. Shaw, Philip E. Shea, Marie B. Syty-Golda, Iwona R. Tarasiewicz, Vernon M. Toyonaga, William B. Watters, Mark L. Waxman, Norma A. Wright, Joel W. Yellin, Janice L. Young, Richard A. Zizzo. Pathologists: Vicky S.M. Chen, Laurence Day, Franco G. Denardi, John Doucet, Terence J. D'Souza, Leelamma J. Elavathil, Bernard J.J. Fernandes, Geoffrey W. Gardiner, R. Warren J. Hartwick, Suhas B. Joshi, Linda R. Kapusta, Norbert A. Kerenyi, Arnost Kolin, King S. Lee, Francesca V. Lobo, Alan Medline, Izabella Morava-Protzner, Brendan J. Mullen, Keith F. Oliveira, Ali H. Qizilbash, Solomon Rabinovich, John T. Roberts, Laila M.I. Sabet, Jose Segura, Ralph W. Shaw, Tasmin K. Sheikh, Hafez S. Shuhaibar, John R. Srigley, Paul S. Thorner. Colposcopists: Richard E. Kalbfleisch, John A. Lamont, Margaret R. Lightheart, Lawrence W. Loopstra, John L. Mazurka, Francois Moens, Donald C. Robinson
Paula Roth
From *the Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ont.; the Departments of †Family Medicine, ‡Clinical Epidemiology and Biostatistics, §Pathology and Molecular Medicine, and Obstetrics and Gynecology, McMaster University, Hamilton, Ont.; **the Father Sean O'Sullivan Research Centre, Hamilton, Ont.; and ††the Digene Corporation, Beltsville, Md. Principal investigators: Alice Lytwyn, John W. Sellors, James B. Mahony, Dean Daya, William Chapman, Noella Ellis, Paula Roth, Attila T. Lorincz, Amiran Gafni. Family practitioners: Nancy L. Abram, Jane E. Anwan, Michael P. Cameron, Larry H. Cowan, David Cree, Andrea Csordas, Nicholas W. Doroszkiewicz, Jennifer Everson, Finola Foley, Peter T. Ford, Elizabeth C. Galbraith, Sameera Ghaznavi, Bronislaw Golda, Allen S. Greenspoon, Alfred B. Gudgeon, Janice A. Harvey, Katalin E. Ivanyi, B. Darrel Juriansz, Allan A. Kopyto, Anne S. Lapinsky, Sheila Mason, Kimberley C. McCallum, S. Kim McMillan, E. Lynn Nash, Rosanne Nishimura, Christopher H. Ragonetti, Marilyn S. Robertson, Matthew G. Robinson, B. Karen Selwyn, J. Elaine Serena, Anne E. Shaw, Philip E. Shea, Marie B. Syty-Golda, Iwona R. Tarasiewicz, Vernon M. Toyonaga, William B. Watters, Mark L. Waxman, Norma A. Wright, Joel W. Yellin, Janice L. Young, Richard A. Zizzo. Pathologists: Vicky S.M. Chen, Laurence Day, Franco G. Denardi, John Doucet, Terence J. D'Souza, Leelamma J. Elavathil, Bernard J.J. Fernandes, Geoffrey W. Gardiner, R. Warren J. Hartwick, Suhas B. Joshi, Linda R. Kapusta, Norbert A. Kerenyi, Arnost Kolin, King S. Lee, Francesca V. Lobo, Alan Medline, Izabella Morava-Protzner, Brendan J. Mullen, Keith F. Oliveira, Ali H. Qizilbash, Solomon Rabinovich, John T. Roberts, Laila M.I. Sabet, Jose Segura, Ralph W. Shaw, Tasmin K. Sheikh, Hafez S. Shuhaibar, John R. Srigley, Paul S. Thorner. Colposcopists: Richard E. Kalbfleisch, John A. Lamont, Margaret R. Lightheart, Lawrence W. Loopstra, John L. Mazurka, Francois Moens, Donald C. Robinson
Attila T. Lorincz
From *the Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ont.; the Departments of †Family Medicine, ‡Clinical Epidemiology and Biostatistics, §Pathology and Molecular Medicine, and Obstetrics and Gynecology, McMaster University, Hamilton, Ont.; **the Father Sean O'Sullivan Research Centre, Hamilton, Ont.; and ††the Digene Corporation, Beltsville, Md. Principal investigators: Alice Lytwyn, John W. Sellors, James B. Mahony, Dean Daya, William Chapman, Noella Ellis, Paula Roth, Attila T. Lorincz, Amiran Gafni. Family practitioners: Nancy L. Abram, Jane E. Anwan, Michael P. Cameron, Larry H. Cowan, David Cree, Andrea Csordas, Nicholas W. Doroszkiewicz, Jennifer Everson, Finola Foley, Peter T. Ford, Elizabeth C. Galbraith, Sameera Ghaznavi, Bronislaw Golda, Allen S. Greenspoon, Alfred B. Gudgeon, Janice A. Harvey, Katalin E. Ivanyi, B. Darrel Juriansz, Allan A. Kopyto, Anne S. Lapinsky, Sheila Mason, Kimberley C. McCallum, S. Kim McMillan, E. Lynn Nash, Rosanne Nishimura, Christopher H. Ragonetti, Marilyn S. Robertson, Matthew G. Robinson, B. Karen Selwyn, J. Elaine Serena, Anne E. Shaw, Philip E. Shea, Marie B. Syty-Golda, Iwona R. Tarasiewicz, Vernon M. Toyonaga, William B. Watters, Mark L. Waxman, Norma A. Wright, Joel W. Yellin, Janice L. Young, Richard A. Zizzo. Pathologists: Vicky S.M. Chen, Laurence Day, Franco G. Denardi, John Doucet, Terence J. D'Souza, Leelamma J. Elavathil, Bernard J.J. Fernandes, Geoffrey W. Gardiner, R. Warren J. Hartwick, Suhas B. Joshi, Linda R. Kapusta, Norbert A. Kerenyi, Arnost Kolin, King S. Lee, Francesca V. Lobo, Alan Medline, Izabella Morava-Protzner, Brendan J. Mullen, Keith F. Oliveira, Ali H. Qizilbash, Solomon Rabinovich, John T. Roberts, Laila M.I. Sabet, Jose Segura, Ralph W. Shaw, Tasmin K. Sheikh, Hafez S. Shuhaibar, John R. Srigley, Paul S. Thorner. Colposcopists: Richard E. Kalbfleisch, John A. Lamont, Margaret R. Lightheart, Lawrence W. Loopstra, John L. Mazurka, Francois Moens, Donald C. Robinson
Amiran Gafni
From *the Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ont.; the Departments of †Family Medicine, ‡Clinical Epidemiology and Biostatistics, §Pathology and Molecular Medicine, and Obstetrics and Gynecology, McMaster University, Hamilton, Ont.; **the Father Sean O'Sullivan Research Centre, Hamilton, Ont.; and ††the Digene Corporation, Beltsville, Md. Principal investigators: Alice Lytwyn, John W. Sellors, James B. Mahony, Dean Daya, William Chapman, Noella Ellis, Paula Roth, Attila T. Lorincz, Amiran Gafni. Family practitioners: Nancy L. Abram, Jane E. Anwan, Michael P. Cameron, Larry H. Cowan, David Cree, Andrea Csordas, Nicholas W. Doroszkiewicz, Jennifer Everson, Finola Foley, Peter T. Ford, Elizabeth C. Galbraith, Sameera Ghaznavi, Bronislaw Golda, Allen S. Greenspoon, Alfred B. Gudgeon, Janice A. Harvey, Katalin E. Ivanyi, B. Darrel Juriansz, Allan A. Kopyto, Anne S. Lapinsky, Sheila Mason, Kimberley C. McCallum, S. Kim McMillan, E. Lynn Nash, Rosanne Nishimura, Christopher H. Ragonetti, Marilyn S. Robertson, Matthew G. Robinson, B. Karen Selwyn, J. Elaine Serena, Anne E. Shaw, Philip E. Shea, Marie B. Syty-Golda, Iwona R. Tarasiewicz, Vernon M. Toyonaga, William B. Watters, Mark L. Waxman, Norma A. Wright, Joel W. Yellin, Janice L. Young, Richard A. Zizzo. Pathologists: Vicky S.M. Chen, Laurence Day, Franco G. Denardi, John Doucet, Terence J. D'Souza, Leelamma J. Elavathil, Bernard J.J. Fernandes, Geoffrey W. Gardiner, R. Warren J. Hartwick, Suhas B. Joshi, Linda R. Kapusta, Norbert A. Kerenyi, Arnost Kolin, King S. Lee, Francesca V. Lobo, Alan Medline, Izabella Morava-Protzner, Brendan J. Mullen, Keith F. Oliveira, Ali H. Qizilbash, Solomon Rabinovich, John T. Roberts, Laila M.I. Sabet, Jose Segura, Ralph W. Shaw, Tasmin K. Sheikh, Hafez S. Shuhaibar, John R. Srigley, Paul S. Thorner. Colposcopists: Richard E. Kalbfleisch, John A. Lamont, Margaret R. Lightheart, Lawrence W. Loopstra, John L. Mazurka, Francois Moens, Donald C. Robinson
From *the Department of Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ont.; the Departments of †Family Medicine, ‡Clinical Epidemiology and Biostatistics, §Pathology and Molecular Medicine, and Obstetrics and Gynecology, McMaster University, Hamilton, Ont.; **the Father Sean O'Sullivan Research Centre, Hamilton, Ont.; and ††the Digene Corporation, Beltsville, Md. Principal investigators: Alice Lytwyn, John W. Sellors, James B. Mahony, Dean Daya, William Chapman, Noella Ellis, Paula Roth, Attila T. Lorincz, Amiran Gafni. Family practitioners: Nancy L. Abram, Jane E. Anwan, Michael P. Cameron, Larry H. Cowan, David Cree, Andrea Csordas, Nicholas W. Doroszkiewicz, Jennifer Everson, Finola Foley, Peter T. Ford, Elizabeth C. Galbraith, Sameera Ghaznavi, Bronislaw Golda, Allen S. Greenspoon, Alfred B. Gudgeon, Janice A. Harvey, Katalin E. Ivanyi, B. Darrel Juriansz, Allan A. Kopyto, Anne S. Lapinsky, Sheila Mason, Kimberley C. McCallum, S. Kim McMillan, E. Lynn Nash, Rosanne Nishimura, Christopher H. Ragonetti, Marilyn S. Robertson, Matthew G. Robinson, B. Karen Selwyn, J. Elaine Serena, Anne E. Shaw, Philip E. Shea, Marie B. Syty-Golda, Iwona R. Tarasiewicz, Vernon M. Toyonaga, William B. Watters, Mark L. Waxman, Norma A. Wright, Joel W. Yellin, Janice L. Young, Richard A. Zizzo. Pathologists: Vicky S.M. Chen, Laurence Day, Franco G. Denardi, John Doucet, Terence J. D'Souza, Leelamma J. Elavathil, Bernard J.J. Fernandes, Geoffrey W. Gardiner, R. Warren J. Hartwick, Suhas B. Joshi, Linda R. Kapusta, Norbert A. Kerenyi, Arnost Kolin, King S. Lee, Francesca V. Lobo, Alan Medline, Izabella Morava-Protzner, Brendan J. Mullen, Keith F. Oliveira, Ali H. Qizilbash, Solomon Rabinovich, John T. Roberts, Laila M.I. Sabet, Jose Segura, Ralph W. Shaw, Tasmin K. Sheikh, Hafez S. Shuhaibar, John R. Srigley, Paul S. Thorner. Colposcopists: Richard E. Kalbfleisch, John A. Lamont, Margaret R. Lightheart, Lawrence W. Loopstra, John L. Mazurka, Francois Moens, Donald C. Robinson
Article Figures & Tables
Figures
Fig. 1: Profile of trial. R = randomization, HSIL = high-grade squamous intraepithelial lesion, ASCUS = atypical squamous cells of undetermined significance, LSIL = low-grade squamous intraepithelial lesion.
Tables
Table 1.
Table 2.
Table 4.
Table 3.
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Comparison of human papillomavirus DNA testing and repeat Papanicolaou test in women with low-grade cervical cytologic abnormalities: a randomized trial
Alice Lytwyn, John W. Sellors, James B. Mahony, Dean Daya, William Chapman, Noella Ellis, Paula Roth, Attila T. Lorincz, Amiran Gafni, The HPV Effectiveness in Lowgrade Paps (HELP) Study No. 1 Group
CMAJ Sep 2000, 163 (6) 701-707;
Comparison of human papillomavirus DNA testing and repeat Papanicolaou test in women with low-grade cervical cytologic abnormalities: a randomized trial
Alice Lytwyn, John W. Sellors, James B. Mahony, Dean Daya, William Chapman, Noella Ellis, Paula Roth, Attila T. Lorincz, Amiran Gafni, The HPV Effectiveness in Lowgrade Paps (HELP) Study No. 1 Group
CMAJ Sep 2000, 163 (6) 701-707;
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