Fig. 2: NSAID mini-management schema. PPI = proton-pump inhibitor, H2-RA = H2-receptor antagonist, COX = cyclooxygenase.
*Most of the data in this area are for omeprazole (20 or 40 mg once daily) in NSAID-induced duodenal and gastric ulcers. Lansoprazole (15 or 30 mg once daily) has been shown to be significantly better than ranitidine in the healing of acute NSAID-induced gastric ulcers. There are no data for pantoprazole.
†Data for misoprostol only.
‡There are data only for high-dose famotidine (40 mg twice daily). Ranitidine (300 mg twice daily) did prevent duodenal but not gastric ulcers in a small study.