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Letters

Patient compliance with drug therapy for diabetic nephropathy

Dyfrig Hughes and Braden Manns
CMAJ May 30, 2000 162 (11) 1553;
Dyfrig Hughes
Prescribing Research Group University of Liverpool Liverpool, UK Internist Calgary, Alta.
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Braden Manns
Prescribing Research Group University of Liverpool Liverpool, UK Internist Calgary, Alta.
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William Clark and colleagues were clearly sensitive to the effects of patient compliance in their study of the cost-effectiveness of angiotensin- converting-enzyme (ACE) inhibitor therapy for diabetic nephropathy.1 This highlights 3 important assumptions regarding compliance that require further clarification.

First, it was assumed that noncompliers lose renal function at the same rate as patients in the placebo arm of a diabetic nephropathy trial comparing the effects of ACE inhibitors and placebo.2 It would seem unlikely that patients taking up to 80% of their ACE inhibitor (the definition Clark and colleagues offered for noncompliance) would lose renal function at the same rate as those taking none. The rate at which noncompliers lose renal function should have been subjected to sensitivity analysis.

Second, the authors based their analysis on the results of a patient- interview study3 in which 34% of patients stated cost as the primary barrier to compliance. To suggest that 34% of patients would be noncompliant for this reason is a major assumption. A recent observational study of persistence with antihypertensive therapy suggested that the relationship between drug cost and compliance was less clear.4 The more expensive ACE inhibitors were in fact associated with higher persistence rates. Thus, when one is evaluating the implications of noncompliance, factors other than drug costs must not be ignored.

Finally, provincial drug coverage may not have had as much impact as assumed because a proportion of patients already have the cost of their medications covered through private insurance. Before ACE inhibitor coverage becomes standard practice, we propose that the effect on compliance of providing medications free at the point of delivery should be more thoroughly assessed. If such studies confirm that compliance improves significantly, then consideration could, in fact, be given to developing a national pharmacare program, whereby cost-effective medications, such as ACE inhibitors for diabetic nephropathy, would be provided free to all Canadians.

Competing interests: None declared.

References

  1. 1.↵
    Clark WF, Churchill DN, Forwell L, Macdonald G, Foster S. To pay or not to pay? A decision and cost-utility analysis of angiotensin- converting-enzyme inhibitor therapy for diabetic nephropathy. CMAJ 2000;162(2):195-8.
    OpenUrlAbstract/FREE Full Text
  2. 2.↵
    Lewis EJ, Hunsicker LG, Bain RP, Rohde RD, for the Collaborative Study Group. The effect of angiotensin-enzyme inhibition on diabetic nephropathy. N Engl J Med 1993;329:1456-62.
    OpenUrlCrossRefPubMed
  3. 3.↵
    Brand FN, Smith RT, Brand PA. Effect of economic barriers to medical care on patients' noncompliance. Public Health Rep 1977;92:72-8.
    OpenUrlPubMed
  4. 4.↵
    Caro JJ, Speckman JL, Salas M, Raggio G, Jackson JD. Effect of initial drug choice on persistence with antihypertensive therapy: the importance of actual practice data. CMAJ 1999; 160(1):41-6.
    OpenUrlAbstract/FREE Full Text
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CMAJ
Vol. 162, Issue 11
30 May 2000
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Patient compliance with drug therapy for diabetic nephropathy
Dyfrig Hughes, Braden Manns
CMAJ May 2000, 162 (11) 1553;

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CMAJ May 2000, 162 (11) 1553;
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