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Journal Article

Adverse reaction to mefloquine associated with ethanol ingestion

R. C. Wittes and R. Saginur
CMAJ February 15, 1995 152 (4) 515-517;
R. C. Wittes
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R. Saginur
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Abstract

A 40-year-old man with no history of neuropsychiatric illness was taking one 250-mg tablet of mefloquine (MFQ) weekly for malaria prophylaxis while in Tanzania. He experienced no adverse reaction in association with his first two doses. Concurrently with both his third and his fourth dose he consumed about half a litre of whisky. On both occasions he experienced hallucinations, paranoid delusions and suicidal ideation. Thereafter he continued taking the MFQ, abstained completely from ethanol ingestion and had no recurrence of psychiatric symptoms. It is hypothesized that the combination of MFQ and ethanol caused the two episodes of severe psychiatric disturbance.

  • Copyright © 1995 by Canadian Medical Association
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CMAJ
Vol. 152, Issue 4
15 Feb 1995
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Adverse reaction to mefloquine associated with ethanol ingestion
R. C. Wittes, R. Saginur
CMAJ Feb 1995, 152 (4) 515-517;

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Adverse reaction to mefloquine associated with ethanol ingestion
R. C. Wittes, R. Saginur
CMAJ Feb 1995, 152 (4) 515-517;
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Copyright 2019, Joule Inc. or its licensors. All rights reserved. ISSN 1488-2329 (e) 0820-3946 (p)

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