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Journal Article

Adverse neurologic effects of metoclopramide

J. D. Grimes, M. N. Hassan and D. N. Preston
CMAJ January 01, 1982 126 (1) 23-25;
J. D. Grimes
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M. N. Hassan
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D. N. Preston
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Abstract

Metoclopramide hydrochloride is now commonly prescribed for a variety of gastrointestinal disorders. Over a 2-year period 18 patients with neurologic disorders induced by metoclopramide were assessed at the Parkinson's disease clinic of the Ottawa Civic Hospital. During metoclopramide therapy acute transient dystonic reactions were seen in 4 patients, and parkinsonism, which was frequently misdiagnosed and treated as classic Parkinson's disease, was seen in 12 patients. After treatment with metoclopramide was stopped, tardive dyskinesia appeared in seven patients and has persisted for up to 15 months in three patients. Parkinsonism and tardive dyskinesia occurred in older patients undergoing long-term therapy with metoclopramide. This experience, therefore, suggests that such treatment, especially in older patients, should be avoided.

  • Copyright © 1982 by Canadian Medical Association
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Vol. 126, Issue 1
1 Jan 1982
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Adverse neurologic effects of metoclopramide
J. D. Grimes, M. N. Hassan, D. N. Preston
CMAJ Jan 1982, 126 (1) 23-25;

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Adverse neurologic effects of metoclopramide
J. D. Grimes, M. N. Hassan, D. N. Preston
CMAJ Jan 1982, 126 (1) 23-25;
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Copyright 2021, Joule Inc. or its licensors. All rights reserved. ISSN 1488-2329 (e) 0820-3946 (p)

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