Background: In previous studies, maternal exposure to folic acid antagonists was associated
with increased risks of neural tube defects, cardiovascular defects, oral clefts and urinary …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Previous studies have suggested a
tendency of antifolate drugs to be associated with higher rates of neural tube defects. WHAT …

Background Multivitamin supplementation in pregnant women may reduce the risks of
cardiovascular defects, oral clefts, and urinary tract defects in their infants. We evaluated …

OBJECTIVE: To provide a comprehensive review of periconceptional folic acid
supplementation and factors affecting folate supplementation trials. DATA SOURCES: A …

Although there is accumulating evidence regarding the additional protective effect of folic
acid against adverse pregnancy outcomes other than neural tube defects, these effects have …

Since the protective effect of folic acid (FA) on birth defects is well known, it is reasonable to
assume intrauterine exposure to FA antagonists increases the risk on these defects. We …

Most studies on safety/risk of drugs in pregnancy consider the proportion of births (but not
pregnancy terminations) affected by the drug from all exposed infants. Lack of data on …

Background Hypertensive disorders of pregnancy are among the leading causes of
maternal morbidity and mortality. Studies suggest that the use of folic acid may lower the risk …

The authors investigated a possible association of supplemental folic acid and multivitamin
use with placental abruption by using data on 280,127 singleton deliveries recorded in 1999 …

Objective To investigate the effect of folic acid (FA) supplementation on the risks of preterm
delivery (PTD) and small for gestational age births (SGA). Data sources Cohort studies were …