CMAJ| SEPTEMBER 10, 2018| VoluME 190| ISSuE 36 E1059 in Sepsis-3 indicates severe
illness; it is not clinically equivalent to a screening test (ie, a trigger for the start of treatment) …

Objective: The Third International Consensus Definitions Task Force (Sepsis-3) recently
recommended changes to the definitions of sepsis. The impact of these changes remains …

Sepsis is a major cause of death, disability, and cost to the health care system. However,
despite its clinical significance, sepsis is difficult to define. For more than 2 decades, the …

Importance Definitions of sepsis and septic shock were last revised in 2001. Considerable
advances have since been made into the pathobiology (changes in organ function …

Over the past 30 years, 2 major factors have led to a perceived need for better definitions. In
particular, the increasing sophistication, at least in high-income countries, of modalities …

The Society of Critical Care Medicine and the European Society of Intensive Care Medicine
recently released a consensus statement redefining the clinical syndrome of sepsis. The …

Importance The Third International Consensus Definitions Task Force defined sepsis as “life-
threatening organ dysfunction due to a dysregulated host response to infection.” The …

Objectives Sepsis-3 definitions generated controversies regarding their general
applicability. The Sepsis-3 Task Force outlined the need for validation with emphasis on the …

Importance Septic shock currently refers to a state of acute circulatory failure associated with
infection. Emerging biological insights and reported variation in epidemiology challenge the …

Despite improvements in diagnosis and management, sepsis and septic shock remain
frequent causes of morbidity and mortality. Singer and colleagues [1–3] recently updated the …