Background: Metformin is widely accepted as first-line pharmacotherapy for patients with
type 2 diabetes mellitus when glycemic control cannot be achieved by lifestyle interventions …

Background Although there is general agreement that metformin should be used as first-line
pharmacotherapy in patients with type 2 diabetes, uncertainty remains regarding the choice …

Background Patients with type 2 diabetes (T2D) typically use several drug treatments during
their lifetime. There is a debate about the best second-line therapy after metformin …

Context: After failure of metformin monotherapy, many second-line, glucose-lowering
therapies are available to treat people with type 2 diabetes. Objective: The objective of the …

Introduction When first line therapy with metformin is insufficient for patients with type 2
diabetes (T2D), the optimal adjunctive therapy is unclear. We assessed the efficacy and …

Background Worldwide, there is an increasing incidence of type 2 diabetes mellitus (T2DM).
Metformin is still the recommended first‐line glucose‐lowering drug for people with T2DM …

Importance Numerous glucose-lowering drugs are used to treat type 2 diabetes. Objective
To estimate the relative efficacy and safety associated with glucose-lowering drugs including …

OBJECTIVE While metformin is generally accepted as the first-line agent in treatment of type
2 diabetes, there are insufficient evidence and extensive debate about the best second-line …

Metformin is a biguanide that is used as first-line treatment of type 2 diabetes mellitus and is
effective as monotherapy and in combination with other glucose-lowering medications. It is …

Aims To compare the efficacy and safety of antihyperglycemic agents, taken in combination
with metformin, for the treatment of type 2 diabetes mellitus (T2DM). Methods A previous …