Low-dose oral vitamin K therapy for the management of asymptomatic patients with elevated international normalized ratios: a brief review

SE Wilson, HG Watson, MA Crowther - CMAJ, 2004 - Can Med Assoc
ASYMPTOMATIC ELEVATION OF THE INTERNATIONAL normalized ratio (INR) is a
common problem associated with hemorrhage. Evidence from randomized controlled trials …

Vitamin K for the treatment of asymptomatic coagulopathy associated with oral anticoagulant therapy

MA Crowther, S Wilson - Journal of thrombosis and thrombolysis, 2003 - Springer
Patients with asymptomatic elevated International Normalized Ratios (INRs) are commonly
seen in practice, but there is no consensus on how best to manage this condition. Evidence …

Low-dose oral vitamin K is safe and effective for outpatient management of patients with an INR> 10

KE Gunther, G Conway, L Leibach, MA Crowther - Thrombosis research, 2004 - Elsevier
Background: Low-dose oral vitamin K effectively returns an international normalized ratio
(INR) between 4.5 and 10.0 to an INR of 2.0–3.0 within 24 h in about 70% of patients …

Low-dose vitamin K therapy in excessively anticoagulated patients: a dose-finding study

MT Brophy, LD Fiore, D Deykin - Journal of Thrombosis and Thrombolysis, 1997 - Springer
Rapid reduction of excessively high international normalized ratio (INR) values into the
therapeutic range is necessary in patients who must be maintained on oral anticoagulants …

Vitamin K supplementation to decrease variability of International Normalized Ratio in patients on vitamin K antagonists: a literature review

SK Ford, S Moll - Current opinion in hematology, 2008 - journals.lww.com
Vitamin K supplementation to decrease variability of Interna... : Current Opinion in
Hematology Vitamin K supplementation to decrease variability of International Normalized …

International normalized ratio monitoring of vitamin K antagonist therapy: comparative performance of point-of-care and laboratory-derived testing

R Bonar, S Mohammed… - Seminars in thrombosis …, 2015 - thieme-connect.com
The monitoring of warfarin therapy using the international normalized ratio (INR) has now
moved outside the laboratory's control by use of point-of-care (POC) devices. Although this …

Management of excessive anticoagulant effect due to vitamin K antagonists

F Dentali, MA Crowther - ASH Education Program Book, 2008 - ashpublications.org
Unexpectedly elevated INR values are commonly encountered in clinical practice. In the
absence of bleeding, such values may be treated with either simple warfarin withdrawal or …

Impact of pre-treatment INR level on the effect of intravenous low dose vitamin K in patients with excessive anticoagulation

A Lubetsky, Y Shasha, D Olchovsky… - Thrombosis and …, 2003 - thieme-connect.com
Administration of vitamin K is the common mode of treatment in excessively anticoagulated
patients. However, patient's response to vitamin K varies, depending on the vitamin K dose …

Oral vitamin K effectively treats international normalised ratio (INR) values in excess of 10

MA Crowther, D Garcia, W Ageno… - Thrombosis and …, 2010 - thieme-connect.com
Unanticipated elevation of the INR is common in patients receiving warfarin. We performed a
prospective cohort study of 107 warfarintreated patients with INR values of more than 10 …

Evaluation of response to high-dose intravenous vitamin K administration

AR Chapman, JR Yerke, M Lumpkin… - Annals of …, 2023 - journals.sagepub.com
Background: Essential to the coagulation pathway, vitamin K (phytonadione) is used to
correct clotting factor deficiencies and for reversal of warfarin-induced bleeding. In practice …