[HTML][HTML] Frailty: joining the giants

P Crome, F Lally - Cmaj, 2011 - Can Med Assoc
Crome has received grants from the United Kingdom's National Institute for Health Research
and Lilly, and from the European Union to study increasing participation of older people in …

[HTML][HTML] Frailty and resilience as outcome measures in clinical trials and geriatric care: are we getting any closer?

GA Kuchel - Journal of the American Geriatrics Society, 2018 - ncbi.nlm.nih.gov
Frailty is fundamental to the science and practice of geriatric medicine and this overarching
concept resonates with all involved in the care of older patients.“Frailty” citations in PubMed …

Research on frailty: Where we stand and where we need to go

L Rodríguez-Mañas, I Rodriguez-Sánchez - Journal of the American …, 2021 - jamda.com
More than a century ago, Elie Metchnikoff, winner of the Nobel Prize of Physiology and
Medicine in 1908, proposed the term gerontology to define the “scientific study of old age.” 1 …

Frailty: implications for clinical practice and public health

EO Hoogendijk, J Afilalo, KE Ensrud, P Kowal, G Onder… - The Lancet, 2019 - thelancet.com
Frailty is an emerging global health burden, with major implications for clinical practice and
public health. The prevalence of frailty is expected to rise alongside rapid growth in the …

Designing drug trials for frailty: ICFSR Task Force 2018

M Pahor, SB Kritchevsky, DL Waters… - The Journal of frailty & …, 2018 - Springer
To reduce disability and dependence in older adults, frailty may represent an appropriate
target for intervention. While preventing frailty through lifestyle interventions may be the …

Frailty in elderly people: an evolving concept.

K Rockwood, RA Fox, P Stolee… - CMAJ: Canadian …, 1994 - ncbi.nlm.nih.gov
Les termes<< frele>> et<< fragilite>> sont tres repandus dans les publications sur la
geriatrie et la gerontologie, mais qui sont les<< personnes agees freles>>? Dans la plupart …

The challenges of clinical trials in the exclusion zone: the case of the frail elderly

I Ridda, R Lindley, RC MacIntyre - Australasian journal on …, 2008 - Wiley Online Library
Frail older people have been systematically excluded from randomised controlled trials
(RCT). We aim to recruit older, frail hospitalised patients in an RCT and evaluate the frailty …

Drug trials for older people

RI Lindley - Journals of Gerontology Series A: Biomedical …, 2012 - academic.oup.com
We are living in an era of unprecedented aging, with over a billion older people expected to
be alive within a few decades. Despite this predictable demographic, drug trials have not …

[CITATION][C] Drug therapy and frailty: chicken or the egg?

PA Rochon, NM Stall… - Journal of the American …, 2019 - Wiley Online Library
This editorial comments on the articles by Bergen et al. and Shmuel et al.

The state of frailty in research: A mapping review of its clinical applicability to practice

QD Nguyen, EM Moodie, P Desmarais, MF Forget… - Ageing research …, 2021 - Elsevier
Research on frailty has expanded in the last decade, but direct evidence supporting its
implementation in clinical practice may be limited. This mapping review synthesizes the …